Pretreatment prognostic value of dynamic contrast-enhanced magnetic resonance imaging vascular, texture, shape, and size parameters compared with traditional survival indicators obtained from locally advanced breast cancer patients

Objectives: The aim of this study was to determine if associations exist between pretreatment dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI)-based metrics (vascular kinetics, texture, shape, size) and survival intervals. Furthermore, the aim of this study was to compare the prognostic value of DCE-MRI parameters against traditional pretreatment survival indicators. Materials and Methods: A retrospective study was undertaken. Approval had previously been granted for the retrospective use of such data, and the need for informed consent was waived. Prognostic value of pretreatment DCE-MRI parameters and clinical data was assessed via Cox proportional hazards models. The variables retained by the final overall survival Cox proportional hazards model were utilized to stratify risk of death within 5 years. Results: One hundred twelve subjects were entered into the analysis. Regarding disease-free survival-negative estrogen receptor status, T3 or higher clinical tumor stage, large ( > 9.8 cm 3 ) MR tumor volume, higher 95th percentile ( > 79%) percentage enhancement, and reduced ( > 0.22) circularity represented the retained model variables. Similar results were noted for the overall survival with negative estrogen receptor status, T3 or higher clinical tumor stage, and large ( > 9.8 cm 3 ) MR tumor volume, again all been retained by the model in addition to higher ( > 0.71) 25th percentile area under the enhancement curve. Accuracy of risk stratification based on either traditional (59%) or DCEMRI (65%) survival indicators performed to a similar level. However, combined traditional and MR risk stratification resulted in the highest accuracy (86%). Conclusions: Multivariate survival analysis has revealed thatmodel-retained DCEMRI variables provide independent prognostic information complementing traditional survival indicators and as such could help to appropriately stratify treatment

Broadbanding Brunswick: High-speed broadband and household media ecologies

New research from the University of Melbourne and Swinburne University has found that 82% of households in the NBN first release site of Brunswick, Victoria, think the NBN is a good idea. The study, Broadbanding Brunswick: High-speed Broadband and Household Media Ecologies, examines the take-up, use and implications of high-speed broadband for some of its earliest adopters. It looks at how the adoption of high-speed broadband influences household consumption patterns and use of telecoms. The survey of 282 Brunswick households found there had been a significant uptake of the NBN during the course of the research. In 2011, 20% of households were connected to the NBN and in 2012 that number had risen to 34%. Families, home owners, higher income earners and teleworkers were most likely to adopt the NBN. Many NBN users reported paying less for their monthly internet bills, with 49% paying about the same. In many cases those paying more (37%) had elected to do so.Download report: Broadbanding Brunswick: High-speed Broadband and Household Media Ecologies [PDF, 2.5MB] Download report: Broadbanding Brunswick: High-speed Broadband and Household Media Ecologies [Word 2007 document, 5MB

Users and non-users of next generation broadband

This paper explores the contexts and motivations that underpin the uptake of Australia’s National Broadband Network (NBN). The findings are drawn from a mixed-methods research study of households using surveys and interviews conducted in 2011 and 2012 in an early release site of the NBN rollout. Whilst use and non-use have traditionally been treated as questions of digital access, inequality and exclusion, there is evidence for emerging forms of non-use characterized by more critical and discriminating approaches. We contribute to this evidence, but our findings suggest that use and non-use of high speed broadband do not occur in isolation or as an expression of individual choice, but as part of increasingly dense household media ecologies of digital infrastructures, devices, services and knowledge

'Was it Good for you Darling?' – Intimacy, Sex and Critical Technical Practice

On the basis of forty-two weeks of ethnographic data collected across six pairs of co-habiting partners, we have theorized about the nature of intimacy, developed artifacts for its mediation and explored methods for its study. In this workshop we wish to take this work as our departure point, and reflect on: The importance of problematising intimacy carefully, that is, approaching intimacy critically. The complex and multiple meanings of intimacy in the context of ongoing intimate relationships. The losses and risks attendant on supporting intimacy between distributed couples

Death and the internet: consumer issues for planning and managing digital legacies

The team of Melbourne University researchers examined licencing policies, terms of use agreements and copyright law, and interviewed a range of people, including funeral directors, religious workers, internet content and service providers, as well as estate planning lawyers. The project identified a range of ownership and access issues, and found that many online \u27assets\u27 are left exposed or stranded after death. The researchers concluded that more Australians should include digital registers in, or with, their wills and these should contain passwords and account locations so that material can then be distributed by the Executor or other designated person. A website was also created as part of the project and provides useful tips and information on preparing a digital register. Visit it here: www.digitalheritage.net.a

Self-beating instabilities in bistable devices

Since the observation of optical bistability by Gibbs et al., optical bistability has been the field where researchers from many fields have found a common place to work. More recently, when Ikeda and co-workers discussed the effect of a delayed feedback on instability of a ring cavity containing a non linear dielectric medium, and pointed out that the transmitted light from the ring cavity can be periodic or chaotic in time under a certain condition, optical bistable devices have shown new possibilities to be applied in many different fields. The novel phenomenon has been predicted to be observed in the hybrid optical device and has been confirmed by Gibbs et al. Moreover, as we have shown, a similar effect can be obtained when liquid crystal cells are employed as non linear element

Probability as a physical motive

Recent theoretical progress in nonequilibrium thermodynamics, linking the physical principle of Maximum Entropy Production ("MEP") to the information-theoretical "MaxEnt" principle of scientific inference, together with conjectures from theoretical physics that there may be no fundamental causal laws but only probabilities for physical processes, and from evolutionary theory that biological systems expand "the adjacent possible" as rapidly as possible, all lend credence to the proposition that probability should be recognized as a fundamental physical motive. It is further proposed that spatial order and temporal order are two aspects of the same thing, and that this is the essence of the second law of thermodynamics.Comment: Replaced at the request of the publisher. Minor corrections to references and to Equation 1 added

Ritual Machines I & II: Making Technology at Home

Changing patterns of both work-related mobility and domestic arrangements mean that ‘mobile workers’ face challenges to support and engage in family life whilst travelling for work. Phatic devices offer some potential to provide connection at a distance alongside existing communications infrastructure. Through a bespoke design process, incorporating phases of design ethnography, critical technical practice and provotyping we have developed Ritual Machines I and II as material explorations of mobile workers’ lives and practices. In doing this we sought to reflect upon the practices through which families accomplish mobile living, the values they place in technology for doing ‘family’ at a distance and to draw insights in to the potential roles of digital technology in supporting them. We frame the design of our phatic devices in discussion of processes of bespoke design, offer advice on supporting mobile workers when travelling and articulate the values of making a technology at home when designing for domestic and mobile settings

Bounds on QCD Instantons from HERA

Signals for processes induced by QCD instantons are searched for in HERA data on the hadronic final state in deep-inelastic scattering. The maximally allowed fraction of instanton induced events is found at 95% confidence level to be on the percent level in the kinematic domain 0.0001<x<0.01 and 5 < Q-squared < 100 GeV-squared. The most stringent limits are obtained from the multiplicity distributions.Comment: 14 pages, latex, 9 figures as ps/ep