Scale-invariant cellular automata and self-similar Petri nets

Two novel computing models based on an infinite tessellation of space-time are introduced. They consist of recursively coupled primitive building blocks. The first model is a scale-invariant generalization of cellular automata, whereas the second one utilizes self-similar Petri nets. Both models are capable of hypercomputations and can, for instance, "solve" the halting problem for Turing machines. These two models are closely related, as they exhibit a step-by-step equivalence for finite computations. On the other hand, they differ greatly for computations that involve an infinite number of building blocks: the first one shows indeterministic behavior whereas the second one halts. Both models are capable of challenging our understanding of computability, causality, and space-time.Comment: 35 pages, 5 figure

Pedestrian Wayfinding Under Consideration of Visual Impairment, Blindness, and Deafblindness: A Mixed-Method Investigation Into Individual Experiences and Supporting Elements

In this report we discuss to-date findings of a project that aimed at assessing individual and environmental affordances in the context of human pedestrian wayfinding of visually impaired, blind, and deafblind travelers in public spaces. Our project afforded collaboration, co-design, and co-creation of knowledge between the investigators, partners at the American Printing House of the Blind and GoodMaps, the Portland State University Digital City Testbed Center, and members of the disability community. The objective of the project was to better understand how different wayfinding aids, that is, wayfinding apps, tactile maps, and verbal route descriptions, are employed by visually impaired, blind, and deafblind travelers. On that account, we examined individual wayfinding behavior and experiences of visually impaired travelers who were tasked with the completion of a set of unfamiliar outdoor/indoor routes on the campus of Portland State University. Our methodology incorporated both qualitative and quantitative methods to evaluate the efficacy of wayfinding behavior, in general, and specifically route completion performance across a set of three routes and wayfinding aids. We expect that the insights garnered from our project drive forward the development of standards and innovation in mobile wayfinding in relation to best practices for technology-mediated pedestrian wayfinding of visually impaired, blind, and deafblind travelers in public spaces

Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion

Data Availability: All relevant data are available from the Gene Expression Omnibus at the following accession number: GSE97755. Funding: This work was funded by the German Research Council (DFG) Graduation College 685, Dr. Jekyll and Mr. Hyde: A systems approach to the therapy of nosocomial infections caused by Candida albicans: a commensal organism switches to a deadly pathogen/ PTJ (FKZ: 0315409BBMBF), the Dr. Manfred Plempel-foundation, the Dr. Siegried Stettendorf-Foundation, the InfectERA Program (FunComPath; BMBF FKZ 031L0001A), the Integrated Research and Treatment Center for Sepsis Control and Care (CSCC) project CanBac (BMBF, FKZ: 01EO1002), and the German Research Council (DFG) GZ:HE7565/1-1. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation

Funding: JW and NARG thank the Wellcome Trust (080088, 086827, 075470), The Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (097377) and the European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338) for funding. MGN was supported by a Vici grant of the Netherlands Organisation for Scientific Research. AJPB and DMM were funded by STRIFE, ERC-2009-AdG-249793 and AJPB additionally by FINSysB, PITN-GA-2008-214004 and the BBSRC [BB/F00513X/1]. MDL was supported by the MRC (MR/J008230/1). GDB and SV were funded by the Wellcome Trust (086558) and TB and MK were funded by the Deutsche Forschungsgemeinschaft (Bi 696/3-1; Bi 696/5-2; Bi 696/10-1). MS was supported by the Deutsche Forschungsgemeinschaft (Sch 897/1-3) and the National Institute of Dental and Craniofacial Research (R01 DE017514-01). TDK and RKSM were funded by the National Institute of Health (AR056296, AI101935) and the American Lebanese Syrian Associated Charities (ALSAC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

HD 69686: A Mysterious High Velocity B Star

We report on the discovery of a high velocity B star, HD 69686. We estimate its space velocity, distance, surface temperature, gravity, and age. With these data, we are able to reconstruct the trajectory of the star and to trace it back to its birthplace. We use evolutionary tracks for single stars to estimate that HD 69686 was born 73 Myr ago in the outer part of our Galaxy ($r \sim 12$ kpc) at a position well below the Galactic plane ($z \sim -1.8$ kpc), a very unusual birthplace for a B star. Along the star's projected path in the sky, we also find about 12 other stars having similar proper motions, and their photometry data suggest that they are located at the same distance as HD 69686 and probably have the same age. We speculate on the origin of this group by star formation in a high velocity cloud or as a Galactic merger fragment.Comment: 28 pages, 6 figures, accepted for publication in Ap

Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans

<p>Abstract</p> <p>Background</p> <p>Invasion of host tissue by the human fungal pathogen <it>Candida albicans </it>is an important step during the development of candidosis. However, not all <it>C. albicans </it>strains possess the same invasive and virulence properties. For example, the two clinical isolates SC5314 and ATCC10231 differ in their ability to invade host tissue and cause experimental infections. Strain SC5314 is invasive whereas strain ATCC10231 is non-invasive and strongly attenuated in virulence compared to SC5314. In this study we compare the <it>in vitro </it>phenotypic, transcriptional and genomic profiles of these two widely used laboratory strains in order to determine the principal biological and genetic properties responsible for their differential virulence.</p> <p>Results</p> <p>In all media tested, the two strains showed the same metabolic flexibility, stress resistance, adhesion properties and hydrolytic enzyme secretion <it>in vitro</it>. However, differences were observed in response to cell-surface disturbing agents and alkaline pH. Furthermore, reduced hyphal formation in strain ATCC10231 under certain conditions correlated with reduced invasive properties in an <it>in vitro </it>invasion assay and a reduced ability to invade epithelial tissue. Despite these diverse phenotypic properties, no substantial genomic differences were detected by comparative genome hybridisation within the open reading frames. However, <it>in vitro </it>transcriptional profiling displayed major differences in the gene expression of these two strains, even under normal <it>in vitro </it>growth conditions.</p> <p>Conclusion</p> <p>Our data suggest that the reason for differential virulence of <it>C. albicans </it>strains is not due to the absence of specific genes, but rather due to differences in the expression, function or activity of common genes.</p