Structure and Kinematics of Molecular Disks in Fast-Rotator Early-Type Galaxies

We present interferometric observations resolving the CO emission in the four gas-rich lenticular galaxies NGC 3032, NGC 4150, NGC 4459, and NGC 4526, and we compare the CO distribution and kinematics to those of the stars and ionized gas. Counterrotation documents an external origin for the gas in at least one case (NGC 3032), and the comparisons to stellar and ionized gas substructures in all four galaxies offer insights into their formation histories. The molecular gas is found in kpc-scale disks with mostly regular kinematics and average surface densities of 100 to 200 \msunsqpc. The disks are well aligned with the stellar photometric and kinematic axes. In the two more luminous Virgo Cluster members NGC 4459 and NGC 4526 the molecular gas shows excellent agreement with circular velocities derived independently from detailed modeling of stellar kinematic data. There are also two puzzling instances of disagreements between stellar kinematics and gas kinematics on sub-kpc scales. In the inner arcseconds of NGC 3032 the CO velocities are significantly lower than the inferred circular velocities, and the reasons may possibly be related to the external origin of the gas but are not well understood. In addition, the very young population of stars in the core of NGC 4150 appears to have the opposite sense of rotation from the molecular gas.Comment: ApJ, accepte

Double-standards in reporting of risk and responsibility for sexual health: a qualitative content analysis of negatively toned UK newsprint articles

Background: The need to challenge messages that reinforce harmful negative discourses around sexual risk and responsibility is a priority in improving sexual health. The mass media are an important source of information regularly alerting, updating and influencing public opinions and the way in which sexual health issues are framed may play a crucial role in shaping expectations of who is responsible for sexual health risks and healthy sexual practices. Methods: We conducted an in-depth, qualitative analysis of 85 negatively toned newspaper articles reporting on sexual health topics to examine how risk and responsibility have been framed within these in relation to gender. Articles published in 2010 in seven UK and three Scottish national newspapers were included. A latent content analysis approach was taken, focusing on interpreting the underlying meaning of text. Results: A key theme in the articles was men being framed as a risk to women's sexual health, whilst it was part of a women's role to "resist" men's advances. Such discourses tended to portray a power imbalance in sexual relationships between women and men. A number of articles argued that it was women who needed to take more responsibility for sexual health. Articles repeatedly suggested that women and teenage girls in particular, lacked the skills and confidence to negotiate safer sex and sex education programmes were often presented as having failed. Men were frequently portrayed as being more promiscuous and engaging in more risky sexual health behaviours than women, yet just one article drew attention to the lack of focus on male responsibility for sexual health. Gay men were used as a bench mark against which rates were measured and framed as being a risk and at risk Conclusions: The framing of men as a risk to women, whilst women are presented at the same time as responsible for patrolling sexual encounters, organising contraception and preventing sexual ill health reinforces gender stereotypes and undermines efforts to promote a collective responsibility for sexual health. This has implications for sexual ill health prevention and could continue to reinforce a negative culture around sex, relationships and sexual health in the UK

Morphologic and histologic comparisons between in vivo and nuclear transfer derived porcine embryos

The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.Title from title screen of research.pdf file viewed on (February 9, 2007)Includes bibliographical references.Thesis (M.S.) University of Missouri-Columbia 2006.Dissertations, Academic -- University of Missouri--Columbia -- Animal sciences..Nuclear transfer (NT) is an inefficient but invaluable tool. This study examines abnormalities associated with NT porcine embryos at days 10, 12, and 14. Methods: 4 experimental groups were examined: non-pregnant, in vivo pregnant, NT recipients, and manipulation control (MC) recipients. Maternal blood samples were collected and assayed for insulin-like growth factor-1 (IGF-1). Embryos were evaluated for embryonic disc diameter, morphology, nucleoli density and mitotic figure index. Results: NT day 12 (P < 0.03) and day 14 (P < 0.01) embryos had increased nucleoli when compared to in vivo produced and MC embryos. NT day 14 embryos had an increased (P < 0.03) mitotic index when compared to in vivo produced day 14 embryos. In vivo produced day 12 embryos had greater (P < 0.03) embryonic disk diameters compared to NT and MC embryos; however in vivo produced day 14 embryos had increased (P < 0.01) embryonic disk diameters only when compared to NT day 14 embryos. In vivo produced day 14 embryos were morphologically more advanced (P < 0.01) than NT and MC day 14 embryos. There were no significant differences between IGF-1 levels. Conclusions: Nuclear transfer embryos develop at a slower rate than in vivo embryos with abnormalities potentially affecting the cell cycle. The techniques used during nuclear transfer also appear to compromise embryo development

Preparing Elementary Writing Teachers: An Inquiry-Driven, Field-Based Approach to Instruction

Pre-service teachers’ [PSTs] preparation for teaching writing is foundational to writing instruction in elementary schools and children’s writing. Prior research has identified elements in writing-focused methods coursework that support their preparation. In this article, an innovative component in a stand-alone writing teacher preparation course that incorporated the research-based elements is showcased: a process for deconstructing and modeling inquiry-driven writing pedagogy. This process includes five phases: (1) using mentor texts during initial immersion, (2) using mentor texts to study structure, (3) using mentor texts to study writer’s craft, (4) using mentor texts to study sentence structure, sentence fluency, and language, and (5) final editing and “going public.” PSTs were engaged as writers of Slice-of-Life stories using this process before being asked to use the same approach in their field work. Research related to using such experiences with PSTs is also shared

Lack of analgesic efficacy in female rats of\ud the commonly recommended oral dose of\ud buprenorphine

Previous work in our laboratory showed that the recommended oral dose of buprenorphine (0.5 mg/kg) was not as effective\ud as the standard therapeutic subcutaneous dose for postoperative analgesia in male Long-Evans (hooded) and Sprague-Dawley (albino) rats. The aim of the current study was to extend this analysis to female rats. We measured the pain threshold in adult female rats in diestrus or proestrus before and 30 and 60 min after oral buprenorphine (0.5 mg/kg,), the standard subcutaneous dose of buprenorphine (0.05 mg/kg), or vehicle only (1 ml/kg each orally and subcutaneously). Female rats showed an increased pain threshold (analgesia) after subcutaneous buprenorphine but no change in pain threshold after either oral buprenorphine or vehicle only. Estrous cycle stage (proestrus versus diestrus) did not affect the analgesic effects of buprenorphine, but rats in proestrus showed significantly lower pain thresholds (less tolerance to pain) than did those in diestrus. These results show that the oral dose of buprenorphine recommended for postoperative analgesic care does not induce significant analgesia in female rats and therefore is not as effective as the standard subcutaneous dose

Multi-Atlas Segmentation using Partially Annotated Data: Methods and Annotation Strategies

Multi-atlas segmentation is a widely used tool in medical image analysis, providing robust and accurate results by learning from annotated atlas datasets. However, the availability of fully annotated atlas images for training is limited due to the time required for the labelling task. Segmentation methods requiring only a proportion of each atlas image to be labelled could therefore reduce the workload on expert raters tasked with annotating atlas images. To address this issue, we first re-examine the labelling problem common in many existing approaches and formulate its solution in terms of a Markov Random Field energy minimisation problem on a graph connecting atlases and the target image. This provides a unifying framework for multi-atlas segmentation. We then show how modifications in the graph configuration of the proposed framework enable the use of partially annotated atlas images and investigate different partial annotation strategies. The proposed method was evaluated on two Magnetic Resonance Imaging (MRI) datasets for hippocampal and cardiac segmentation. Experiments were performed aimed at (1) recreating existing segmentation techniques with the proposed framework and (2) demonstrating the potential of employing sparsely annotated atlas data for multi-atlas segmentation

Aggressive immunosuppressive treatment of Susac's syndrome in an adolescent: using treatment of dermatomyositis as a model

We describe aggressive immunosuppressive treatment of an adolescent with Susac's syndrome (SS), a disease of the microvasculature in the brain, retina, and inner ear. Because the immunopathogenesis of SS appears to have much in common with that of juvenile dermatomyositis (JDM), the patient was treated with an approach that has been effective for severe JDM. The patient's outcome provides evidence for the importance of prompt, aggressive, and sustained immunosuppressive treatment of encephalopathic SS