COTA: Setting the Standard

Course Code: ENR/AEDE 4567Final paper for the Environment, Economy, Development, and Sustainability capstone course. Analysis of potential greenhouse gas emissions reductions from reduced single-occupancy vehicle use as a result of potential COTA improvements. Includes benchmarking of various public transportation networks for customer service improvements and strategic recommendations for COTA.City of Columbus, OhioAcademic Major: Environment, Economy, Development, and Sustainabilit

Project Themyscira

Currently, both governments and private corporations are developing lunar exploration projects for scientific research and spaceflight operations. However, a viable plan for a lunar base is yet to be developed. The goal of Project Themyscira is to design a self-sufficient, sustainable lunar base capable of supporting five crew members for a period of six months. The feasibility study is two-fold. It will test the effectiveness and efficiency of the life-support systems to accomplish the mission, as well as evaluate its financial and logistic feasibility. In order to study the required systems to support human life, the team conducted an extensive literature survey on previous designs for human settlements in space and their limitations. This assessment yielded a series of constraints for oxygen production, atmospheric modeling, energy production, water treatment, and thermal regulation. Preliminary findings show that while some of the necessary support systems have the technology required to provide the necessary outputs, the logistics to set up the lunar base are not financially feasible. Nonetheless, artificial atmosphere models, artificial photosynthesis and radiation-protected photovoltaic cells are some of the existing technologies that would allow the lunar base to sustain human life. Consequently, optimizing the technologies so that they can be taken to space in smaller dimensions could result in logistical feasibility. The team will focus on developing testing methods to optimize the systems necessary to sustain the lunar base

Perceptions of Social Media Influencers Based on Race, Gender, and Interest

A Research Seminar Project supervised by Dr. Mindy Erchull (Spring 2021)

Regulating Sadness: Response-Independent and Response-Dependent Benefits of Listening to Music

Listening to music is a common method of regulating unpleasant emotions such as sadness, but music listening has not been compared to prototypical interpersonal emotion-regulation strategies. We examined music’s response-independent benefits (i.e., benefits that do not require a response from another person) and response-dependent benefits (i.e., benefits that do require a response from another person) and compared those to other regulation strategies such as talking to a friend and asking someone for advice. College students (N = 353) completed an online survey in which they rated their likelihood of using eight different strategies to regulate sadness and the benefits of using each strategy. Repeated-measures ANOVAs revealed listening to music was the most likely strategy used when sad. Moreover, listening to music provided the most response-independent benefits of any strategy we examined, including talking to a friend and asking someone for advice. Talking to a friend provided more interpersonal support than listening to music did, but listening to music did not provide any less of a shared experience than talking to a friend or asking someone for advice. These findings suggest that listening to music shares much in common with interpersonal emotion-regulation strategies such as talking with other people when sad

A Helping Hand Out of the River: Refugee Perspectives for Provider Engagement

Purpose: A growing number of refugee groups are seeking care within the U.S. health care system for medical, psychological, and social needs. Research is limited in understanding refugee-specific conceptualizations of helping relationships and provider characteristics that improve interactions in health systems. This study aimed to identify provider characteristics that facilitate engagement and helpfulness in a refugee-specific population from refugee participant voices to inform future practices of health care clinics. Methods: Semi-structured interviews with refugee participants were conducted to assess 1) experiences moving on from difficult experiences, 2) engagement with the health system, and 3) provider characteristics that facilitated engagement and healing. Qualitative data were analyzed using a grounded theory approach. Results: An emergent theory was revealed on refugee-defined provider characteristics that facilitated healing and engagement in the health system. Providers who support an individual’s story to be told, show awareness of barriers to accessing resources and prioritization of addressing barriers, maintain cultural humility, and demonstrate compassion, empathy, warmth, and openness toward patient engagement were the primary characteristics that facilitated engagement and healing. Conclusions: Utilization of engagement strategies by providers at the onset of treatment is critical to providing culturally sensitive health care. Nonspecific but essential provider characteristics are thought to improve relational dynamics, trust-building, and overall engagement in the U.S. health care system from the perspective of refugee participants

Does health and medical research consider geographic factors affecting study participants: a retrospective snapshot analysis of 11 leading journals

Background: Research has identified that rurally located persons face health inequities when compared to their urban peers. While health policies and practice frameworks to address the needs of rural people are largely developed on the principles of evidence-based medicine, it is not clear whether this evidence base appropriately considers geographic factors that may impact participant outcomes. The purpose of this project was to examine whether research within leading health and medical journals identified the geographic classification (location) of their participants, thus enabling the original authors and subsequent readers to appropriately consider this factor in the making of policy and practice recommendations. Methods: A retrospective analysis of study participants’ geographic identifiers within articles from medical and health journals was carried out in this project. Eleven journals were chosen for evaluation, with 300 consecutive eligible papers from each journal retrospectively reviewed. All 3300 papers were analyzed to determine whether the research participants’ geographic location was identified. This classification was then stratified into varying categories of rural or urban, as appropriate. Results: It was not possible to identify participants’ geographic location in 2193 (66%) of the 3300 reviewed articles. A total of 121 papers (4%) had sole focus on rural residents, with another 95 articles (3%) comparing outcomes between rural and urban locations. Slightly more than a quarter (27%) of the articles either just featured urban participants or made no distinction between rural and urban locations. Conclusions: These findings indicate that insufficient attention is given to the geographic location of participants. This failure means that the outcomes and recommendations of the research base may be invalid for a large section of the world’s population and result in inequities in healthcare services. There is an emerging concern about using this evidence base for developing health guidelines and policy frameworks, as the needs of a substantial proportion of the population may not have been appropriately captured

Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset

Abstract Animal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic ductal adenocarcinoma (PDAC). However, the tumorigenic potential of human pancreatic acinar cells remains under debate. To address this gap in knowledge, we expand sorted human acinar cells as 3D organoids and genetically modify them through introduction of common PDAC mutations. The acinar organoids undergo dramatic transcriptional alterations but maintain a recognizable DNA methylation signature. The transcriptomes of acinar organoids are similar to those of disease-specific cell populations. Oncogenic KRAS alone do not transform acinar organoids. However, acinar organoids can form PDAC in vivo after acquiring the four most common driver mutations of this disease. Similarly, sorted ductal cells carrying these genetic mutations can also form PDAC, thus experimentally proving that PDACs can originate from both human acinar and ductal cells. RNA-seq analysis reveal the transcriptional shift from normal acinar cells towards PDACs with enhanced proliferation, metabolic rewiring, down-regulation of MHC molecules, and alterations in the coagulation and complement cascade. By comparing PDAC-like cells with normal pancreas and PDAC samples, we identify a group of genes with elevated expression during early transformation which represent potential early diagnostic biomarkers

Happa: The New Frontier of Marginality and Disruption of Long-Static Racial Constructs

Recent reports have noted a rise in interracial marriages, which some say represents a positive change in attitudes toward race and ethnicity. However, the available data shows interracial marriages more often entail a union where one person is the member of the dominant group (e.g., White European). So, why is the percentage of marriage between non-dominants so rare? This chapter discusses whether this is a result of minority groups adopting majority attitudes toward other ethnic groups—a reflection of interethnic group conflict between ethnic groups—or just a reflection of the population and patterns of integration. Still, in its own way, this pattern may reinforce ethnic stereotypes and attitudes to the benefit of the majority group and the continued marginalization of ethnic groups