A local moment approach to the degenerate Anderson impurity model

The local moment approach is extended to the orbitally-degenerate [SU(2N)] Anderson impurity model (AIM). Single-particle dynamics are obtained over the full range of energy scales, focussing here on particle-hole symmetry in the strongly correlated regime where the onsite Coulomb interaction leads to many-body Kondo physics with entangled spin and orbital degrees of freedom. The approach captures many-body broadening of the Hubbard satellites, recovers the correct exponential vanishing of the Kondo scale for all N, and its universal scaling spectra are found to be in very good agreement with numerical renormalization group (NRG) results. In particular the high-frequency logarithmic decays of the scaling spectra, obtained here in closed form for arbitrary N, coincide essentially perfectly with available numerics from the NRG. A particular case of an anisotropic Coulomb interaction, in which the model represents a system of N `capacitively-coupled' SU(2) AIMs, is also discussed. Here the model is generally characterised by two low-energy scales, the crossover between which is seen directly in its dynamics.Comment: 23 pages, 7 figure

The Robertson v. Princeton Case: Too Important to Be Left to the Lawyers

Offers comments from eleven contributors on the Robertson family's donor rights suit against the Woodrow Wilson School of Public and International Affairs for violation of donor intent. Explores its effects on and implications for the nonprofit sector

Impact of different alginate lyases on combined cellulase–lyase saccharification of brown seaweed

Alginate attack characteristics and impact on cellulase–lyase catalyzed saccharification of brown seaweed were compared for three microbial PL7 alginate lyases (EC 4.2.2.-) two of them heterologously expressed in Escherichia coli as part of the work.</p

WIC Participation as a Risk Factor for Loss to Follow-Up in the Wisconsin EHDI System

In 2011, Wisconsin’s Early Hearing Detection and Intervention (EHDI) program, Wisconsin Sound Beginnings (WSB), developed multiple strategies to reduce loss to follow-up (LTFU) for babies who did not pass their newborn hearing screening: Medical Outreach, Family Outreach, Regional Outreach and WIC Alert. WSB evaluated the outcomes of babies identified as at-risk for LTFU to determine whether WIC participation was an indicator of their risk for LTFU. Additionally, WSB evaluated whether babies who were identified as at-risk for LTFU and receiving WIC services in two WIC projects serving areas and populations with known health disparities, were at even greater risk for LTFU. WSB found no statistically significant differences in outcomes between babies who were WIC participants and those who were not. This paper discusses implications of this research for other EHDI programs

Absolute diffuse calibration of IRAC through mid-infrared and radio study of HII regions

We investigate the diffuse absolute calibration of the InfraRed Array Camera on the Spitzer Space Telescope at 8.0microns using a sample of 43 HII regions with a wide range of morphologies near GLON=312deg. For each region we carefully measure sky-subtracted,point-source- subtracted, areally-integrated IRAC 8.0-micron fluxes and compare these with Midcourse Space eXperiment (MSX) 8.3-micron images at two different spatial resolutions, and with radio continuum maps. We determine an accurate median ratio of IRAC 8.0-micron/MSX\8.3-micron fluxes, of 1.55+/-0.15. From robust spectral energy distributions of these regions we conclude that the present 8.0-micron diffuse calibration of the SST is 36% too high compared with the MSX validated calibration, perhaps due to scattered light inside the camera. This is an independent confirmation of the result derived for the diffuse calibration of IRAC by the Spitzer Science Center (SSC). From regression analyses we find that 843-MHz radio fluxes of HII regions and mid-infrared (MIR) fluxes are linearly related for MSX at 8.3-microns and Spitzer at 8.0 microns, confirming the earlier MSX result by Cohen & Green. The median ratio of MIR/843-MHz diffuse continuum fluxes is 600 times smaller in nonthermal than thermal regions, making it a sharp discriminant. The ratios are largely independent of morphology up to a size of ~24 arcsec. We provide homogeneous radio and MIR morphologies for all sources. MIR morphology is not uniquely related to radio structure. Compact regions may have MIR filaments and/or diffuse haloes, perhaps infrared counter- parts to weakly ionized radio haloes found around compact HII regions. We offer two IRAC colour-colour plots as quantitative diagnostics of diffuse HII regions.Comment: 29 pages, LaTeX (aastex), incl. 31 PostScript (ps,eps) figures and 5 tables. Accepted by MNRAS (main journal). Replaced an unused file and added this URL for people wishing to download a version with high-resolution images: http://www.astro.wisc.edu/sirtf/martin.hii.accepted.pd

Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis

There is a desire to engineer mammalian host cell lines to improve cell growth/biomass accumulation and recombinant biopharmaceutical protein production in industrially relevant cell lines such as the CHOK1 and HEK293 cell lines. The over-expression of individual subunits of the eukaryotic translation factor eIF3 in mammalian cells has previously been shown to result in oncogenic properties being imparted on cells, including increased cell proliferation and growth and enhanced global protein synthesis rates. Here we report on the engineering of CHOK1 and HEK cells to over-express the eIF3i and eIF3c subunits of the eIF3 complex and the resultant impact on cell growth and a reporter of exogenous recombinant protein production. Transient over-expression of eIF3i in HEK293 and CHOK1 cells resulted in a modest increase in total eIF3i amounts (maximum 40% increase above control) and an approximate 10% increase in global protein synthesis rates in CHOK1 cells. Stable over-expression of eIF3i in CHOK1 cells was not achievable, most likely due to the already high levels of eIF3i in CHO cells compared to HEK293 cells, but was achieved in HEK293 cells. HEK293 cells engineered to over-express eIF3i had faster growth that was associated with increased c-Myc expression, achieved higher cell biomass and gave enhanced yields of a reporter of recombinant protein production. Whilst CHOK1 cells could not be engineered to over-express eIF3i directly, they could be engineered to over-express eIF3c, which resulted in a subsequent increase in eIF3i amounts and c-Myc expression. The CHOK1 eIF3c engineered cells grew to higher cell numbers and had enhanced cap- and IRES-dependent recombinant protein synthesis. Collectively these data show that engineering of subunits of the eIF3 complex can enhance cell growth and recombinant protein synthesis in mammalian cells in a cell specific manner that has implications for the engineering or selection of fast growing or high producing cells for production of recombinant proteins

From bottom-up to top-down control of invertebrate herbivores in a retrogressive chronosequence

In the long-term absence of disturbance, ecosystems often enter a decline or retrogressive phase which leads to reductions in primary productivity, plant biomass, nutrient cycling and foliar quality. However, the consequences of ecosystem retrogression for higher trophic levels such as herbivores and predators, are less clear. Using a post-fire forested island-chronosequence across which retrogression occurs, we provide evidence that nutrient availability strongly controls invertebrate herbivore biomass when predators are few, but that there is a switch from bottom-up to top-down control when predators are common. This trophic flip in herbivore control probably arises because invertebrate predators respond to alternative energy channels from the adjacent aquatic matrix, which were independent of terrestrial plant biomass. Our results suggest that effects of nutrient limitation resulting from ecosystem retrogression on trophic cascades are modified by nutrient-independent variation in predator abundance, and this calls for a more holistic approach to trophic ecology to better understand herbivore effects on plant communities

Cosmic Vortons and Particle Physics Constraints

We investigate the cosmological consequences of particle physics theories that admit stable loops of superconducting cosmic string - {\it vortons}. General symmetry breaking schemes are considered, in which strings are formed at one energy scale and subsequently become superconducting in a secondary phase transition at what may be a considerably lower energy scale. We estimate the abundances of the ensuing vortons, and thereby derive constraints on the relevant particle physics models from cosmological observations. These constraints significantly restrict the category of admissible Grand Unified theories, but are quite compatible with recently proposed effects whereby superconducting strings may have been formed close to the electroweak phase transition.Comment: 33 pages, 2 figures, RevTe

Evolution of Fields in a Second Order Phase Transition

We analyse the evolution of scalar and gauge fields during a second order phase transition using a Langevin equation approach. We show that topological defects formed during the phase transition are stable to thermal fluctuations. Our method allows the field evolution to be followed throughout the phase transition, for both expanding and non-expanding Universes. The results verify the Kibble mechanism for defect formation during phase transitions.Comment: 12 pages of text plus 17 diagrams available on request, DAMTP 94-8