Reducing HIV infection among youth: What can schools do? Key baseline findings from Mexico, South Africa, and Thailand

Although many program planners see schools as a convenient location for HIV-prevention programs, there is controversy about whether school programs can ever be strong enough to go beyond improving knowledge and attitudes to increasing the adoption of safe sexual behaviors. Evaluations of school programs in Mexico, South Africa, and Thailand focus on this question: Can school HIV programs change behavior? In each country, local organizations have worked with educators on teacher training and course design to ensure high-quality school interventions. Researchers surveyed students’ knowledge, attitudes, norms, and reported behavior before the intervention, immediately after the intervention, and again several months later to measure retention of program effects. In all three sites comparable control groups are compared to the intervention group. The mean age and age ranges for the three study groups are: 16 years and 13–23 for the Mexican study group; 15 years and 8 months and ages 12–21 for the South African study group; and 20 years and ages 17–31 for the Thai study group. This report is a summary of key baseline findings from these studies

Bioinformatic Analysis Reveals High Diversity of Bacterial Genes for Laccase-Like Enzymes

Fungal laccases have been used in various fields ranging from processes in wood and paper industries to environmental applications. Although a few bacterial laccases have been characterized in recent years, prokaryotes have largely been neglected as a source of novel enzymes, in part due to the lack of knowledge about the diversity and distribution of laccases within Bacteria. In this work genes for laccase-like enzymes were searched for in over 2,200 complete and draft bacterial genomes and four metagenomic datasets, using the custom profile Hidden Markov Models for two- and three- domain laccases. More than 1,200 putative genes for laccase-like enzymes were retrieved from chromosomes and plasmids of diverse bacteria. In 76% of the genes, signal peptides were predicted, indicating that these bacterial laccases may be exported from the cytoplasm, which contrasts with the current belief. Moreover, several examples of putatively horizontally transferred bacterial laccase genes were described. Many metagenomic sequences encoding fragments of laccase-like enzymes could not be phylogenetically assigned, indicating considerable novelty. Laccase-like genes were also found in anaerobic bacteria, autotrophs and alkaliphiles, thus opening new hypotheses regarding their ecological functions. Bacteria identified as carrying laccase genes represent potential sources for future biotechnological applications

Programming for HIV prevention in Mexican schools

As national education programs incorporate HIV prevention into school curriculums, policymakers and educators need to know what they can expect from these initiatives. Can such courses influence the behavior of students and improve their knowledge and attitudes? If not, what can these courses reasonably be expected to accomplish, and what part can they play in overall HIV programming for youth? To help answer these questions, the Mexican Institute of Family and Population Research (IMIFAP), the Mexican Ministry of Public Education (SEP), and the Horizons Program examined the effects of a school-based HIV-prevention program on Mexican secondary-school students. All public schools in Mexico must implement sexuality education and teacher-training programs, although the content is left to each state’s discretion. Students must pass this class just as they would other courses in the curriculum. With approval from SEP, a leading Mexican NGO (IMIFAP) experienced in designing sex education courses developed the curriculum and the teacher-training program used in this study. The 30-session student curriculum, described in this brief, focuses on a broad range of topics that aim to equip students with information and skills to prevent HIV infection

Enhancement of underused cervical cancer prevention services in rural Oaxaca, Mexico Incremento en el uso de los servicios de prevención de cáncer cervicouterino en zonas rurales de Oaxaca, México

En este trabajo se analizan los resultados de la aplicación del programa educacional Porque me quiero, me cuido, denominado actualmente Yo quiero, yo puedo. . . prevenir el cáncer, en poblaciones rurales e indígenas de Valles Centrales, estado de Oaxaca, una de las regiones más pobres de México. Este programa está dirigido a promover el uso de servicios de tamizaje y la prevención del cáncer cervicouterino mediante el cambio de conducta de las personas y la comunidad. Para ello se realizaron talleres interactivos enfocados al desarrollo de habilidades y conocimientos en las mujeres de 15 a 64 años de edad. Estos talleres se complementaron con campañas en la comunidad y talleres para hombres con el fin de conseguir su apoyo. Se cuantificaron las pruebas de Papanicolau realizadas en las 10 poblaciones intervenidas y en 6 poblaciones con características similares empleadas como control. Además se evaluó mediante un cuestionario los cambios en la conducta, los conocimientos y las actitudes. Se observó un numero significativamente mayor de pruebas de Papanicolau realizadas en las poblaciones intervenidas con respecto a las de control (P = 0,02). Se comprobaron cambios positivos en el nivel de conocimientos de las mujeres respecto a las causas del cáncer cervical y las medidas para prevenirlo

Identifying precursors of safer-sex practices in mexican adolescents with and without sexual experience: An exploratory model

Theoretical variables were examined for their empirical relevance as precursors of safer-sex behavior in 2,011 Mexican adolescents, most of whom were not sexually experienced. Using structural equation modeling, a good fit was found for a path model with (a) partner communication and intention to use condoms as outcome variables; (b) self-esteem, self-efficacy, and decision making as antecedent variables; and (c) perceived norms about sexual practices, attitudes toward condom use, and knowledge of HIV as mediating variables. A good fit also was found for a slightly elaborated model involving condom use as out-come variable that was fitted in a subsample with 319 adolescents who reported sexual experience. Gender differences are discussed, as well as implications for intervention programs promoting safer-sex behaviors