Treatment of acquired flexural deformity of the distal interphalangeal joint in the horse: a retrospective study of 51 cases

Flexural deformity of the distal interphalangeal joint is an important disorder in horses, which can be acquired during the first year of life, often as a result of lateralization during grazing. In this retrospective study, the medical files of 51 cases presented at the Faculty of Veterinary Medicine of Ghent University (1999-2013) were analyzed, followed by a telephone questionnaire. In 65% of the conservatively treated patients, the hoof conformation corrected completely, which was not significantly different from what was seen in the surgically treated group (complete correction in 56% of cases). Foals treated conservatively before the age of six months and foals treated surgically before twelve months of age, had a significantly better chance of a successful correction than older foals. Moreover, cases in which treatment did not restore the hoof conformation completely, presented a significantly higher chance of (persisting) lameness and were significantly less likely to have an athletic career. Finally, this study proved a significant association between the hoof conformation of the dam and her foals

Recognition of foreign names spoken by native speakers

It is a challenge to develop a speech recognizer that can handle the kind of lexicons encountered in an automatic attendant or car navigation application. Such lexicons can contain several 100K entries, mainly proper names. Many of these names are of a foreign origin, and native speakers can pronounce them in different ways, ranging from a completely nativized to a completely foreignized pronunciation. In this paper we propose a method that tries to deal with the observed pronunciation variability by introducing the concept of a foreignizable phoneme, and by combining standard acoustic models with a phonologically inspired back-off acoustic model. The main advantage of the approach is that it does not require any foreign phoneme models nor foreign speech data. For the recognition of English names by means of Dutch acoustic models, we obtained a reduction of the word error rate by more than 10% relative

A retrospective study on 195 horses with contaminated and infected synovial cavities

This study analyzes the clinical aspects of contaminated and infected synovial cavities in horses and evaluates their prognosis after treatment. The medical records of 195 affected horses referred between June 1999 and July 2004 were reviewed. Twenty-six horses were euthanized or returned home without further treatment. Therapeutic strategies for the remaining 169 horses were not different from those reported in other recent studies, except that lavage was performed predominantly without endoscopic visualization. Follow-up was obtained by questionnaire for 150 of 169 treated horses. The outcome was considered successful (survival without residual lameness) in 109 of 150 horses (72.7%). Iatrogenic synovial infection, the presence of radiographic signs on admission and the use of regional antibiotic perfusion were significantly related with non-successful outcome. Overall, the outcome in the present study appeared to be slightly less favorable compared to other recent reports, although it certainly improved for horses with deep nail puncture wounds

First-order synchronization transition in a large population of strongly coupled relaxation oscillators.

Onset and loss of synchronization in coupled oscillators are of fundamental importance in understanding emergent behavior in natural and man-made systems, which range from neural networks to power grids. We report on experiments with hundreds of strongly coupled photochemical relaxation oscillators that exhibit a discontinuous synchronization transition with hysteresis, as opposed to the paradigmatic continuous transition expected from the widely used weak coupling theory. The resulting first-order transition is robust with respect to changes in network connectivity and natural frequency distribution. This allows us to identify the relaxation character of the oscillators as the essential parameter that determines the nature of the synchronization transition. We further support this hypothesis by revealing the mechanism of the transition, which cannot be accounted for by standard phase reduction techniques

The use of equine chondrogenic‐induced mesenchymal stem cells as a treatment for osteoarthritis : a randomised, double‐blinded, placebo‐controlled proof‐of‐concept study

Background: There is a need to improve therapies for osteoarthritis in horses. Objectives To assess the efficacy of equine allogeneic chondrogenic-induced mesenchymal stem cells combined with equine allogeneic plasma as a novel therapy for osteoarthritis in horses. Study design: Randomised, double-blinded, placebo-controlled experiment. Methods: In 12 healthy horses, osteoarthritis was induced in the metacarpophalangeal joint using an osteochondral fragment-groove model. Five weeks after surgery, horses were randomly assigned to either an intra-articular injection with chondrogenic-induced mesenchymal stem cells + equine allogeneic plasma (= intervention) or with 0.9% saline solution (= control). From surgery until the study end, horses underwent a weekly joint and lameness assessment. Synovial fluid was collected for cytology and biomarker analysis before surgery and at Weeks 5, 5 + 1d, 7, 9 and 11. At Week 11, horses were subjected to euthanasia, and the metacarpophalangeal joints were evaluated macroscopically and histologically. Results: No serious adverse events or suspected adverse drug reactions occurred during the study. A significant improvement in visual and objective lameness was seen with the intervention compared with the control. Synovial fluid displayed a significantly higher viscosity and a significantly lower glycosaminoglycan concentration in the intervention group. Other biomarkers or cytology parameters were not significantly different between the treatment groups. Significantly less wear lines and synovial hyperaemia were present in the intervention group. The amount of cartilage oligomeric matrix protein, collagen type II and glycosaminoglycans were significantly higher in the articular cartilage of the intervention group. Main limitations: This study assessed the short-term effect of the intervention on a limited number of horses, using an osteoarthritis model. This study also included multiple statistical tests, increasing the risk of type 1 error. Conclusions: Equine allogeneic chondrogenic-induced mesenchymal stem cells combined with equine allogeneic plasma may be a promising treatment for osteoarthritis in horses