OAB score: A clinical model that predicts the probability of presenting overactive detrusor in the urodynamic study

<div><p>ABSTRACT Purpose To create a predictive model of involuntary detrusor contraction (IDC) to improve the diagnostic accuracy of overactive detrusor (OAD), associating overactive bladder (OAB) symptoms with other clinical parameters in the female population. Materials and Methods A total of 727 women were studied retrospectively. In all of them, urodynamic study was conducted for urogynecological causes. Demographics information, personal history, symptoms, physical exam, a 3-day frequency/volume chart and urinary culture, were collected in all patients and they subsequently underwent uroflowmetry and urodynamic studies. A logistic regression model was performed in order to determine independent predictors of presence of IDC. Odd ratio (OR) estimation was used to assign a score to each one of the significant variables (p≤0.05) in the logistic regression model. We performed a ROC curve in order to determine the predictive ability of the score in relation to the presence of OAD. Results presence of OAD was evident in 210 women (29%). In the logistic regression analysis, independent predictors of OAD were urgency, urgency incontinence, nocturia, absence of SUI symptoms, diabetes mellitus, reduction of vaginal trophism and bladder capacity below 150 mL. The probability of IDC diagnosis increases as the score raises (Score 0: 4% until Score ≥10: 88%). Sensitivity was 71% and specificity 72%. The area under the curve of OAB score was 0.784 (p>0.001). Conclusions OAB score is a clinical tool that shows higher diagnostic accuracy than OAB symptoms alone to predict overactive detrusor.</p></div

Apolipoprotein E genotypes and means (SD) of circulating lipids in the Aragon Workers Health Study.

<p>*P-values for the difference within each SNP including age as covariate.</p><p>Apolipoprotein E genotypes and means (SD) of circulating lipids in the Aragon Workers Health Study.</p

The Aragon Workers Health Study (AWHS) baseline characteristics.

<p>The Aragon Workers Health Study (AWHS) baseline characteristics.</p

Mean adjusted BMI and standard error for five haplogenotype categories.

<p>Mean adjusted BMI and standard error for five haplogenotype categories.</p

Association between individual APOE SNPs, rs429358 and rs7412, with body fatness.

<p>Means and standard error of the means (SEM) of Body Mass Index (BMI) and waist girth values, adjusted for age, smoking status and lipid values.</p><p>Association between individual APOE SNPs, rs429358 and rs7412, with body fatness.</p

Hematological results from primary blood samples (n = 10) that were used to derive blood preparations.

<p>Hematological results from primary blood samples (n = 10) that were used to derive blood preparations.</p

Hematological results from primary blood samples (n = 10) that were used to derive blood preparations.

<p>Hematological results from primary blood samples (n = 10) that were used to derive blood preparations.</p

Scatter plot of the change of mtDNAcn(WB) per unit increase of the platelets/leukocyte ratio.

<p>This scatter plot shows the change of mtDNAcn(WB) per unit increase of the platelets/leukocyte ratio. Data from 46 preparations are shown. Individual mtDNAcn(WB) for each preparation are plotted as white circles. The line represents the fit of a linear model (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0163770#pone.0163770.t003" target="_blank">Table 3</a>, Model 6). mtDNAcn(WB): mitochondrial DNA copy number measured in whole blood.</p

Coefficients of multivariate regression models for mtDNAcn(WB) measured in blood preparations (n = 46).

<p>Coefficients of multivariate regression models for mtDNAcn(WB) measured in blood preparations (n = 46).</p

Platelet count, Leukocyte count and mtDNAcn(WB) distributions in all subjects from the AWHS cohort study (n = 3389).

<p>Platelet count, Leukocyte count and mtDNAcn(WB) distributions in all subjects from the AWHS cohort study (n = 3389).</p