WPŁYW SPOŻYCIA WYBRANYCH SKŁADNIKÓW POKARMOWYCH NA WYSTĘPOWANIE I PRZEBIEG DEPRESJI

Depression is a disease characterized by both mental and somatic disorders. The 21st century turned out to be the time when depression became a real health threat not only to individuals but also to entire societies. There are many theories pointing to the causes of depression, but these immediate causes are still not definitively clear. Equivalent importance of neuroanatomical and psycho-social factors is indicated. Among the theories considered so far, there are biological, hormonal, neurotransmitter-related, describing the malfunctions of the limbic system and hypothalamus, psychological theories. The studies conducted so far show that psychosocial factors play an extremely important role in the etiology of depression. Symptoms of depression are very complex and multifaceted, and may vary in severity. As a result of studies on the risk factors for depression, a relationship between the deficiency of individual nutrients and the manifestation of depressive disorders has been shown. The aim of the study is to present the influence of particular nutrients on the occurrence and course of depression. A properly balanced diet, both quantitatively and qualitatively, has a positive effect on reducing the risk of depression, as well as improving the condition of people who already suffer from it. Among the nutrients of particular importance are vitamin D, magnesium, folic acid, tryptophan, zinc, omega-3 fatty acids, cobalamin, and some probiotic microorganisms.Depresja jest chorobą, którą charakteryzują zarówno zaburzenia psychiczne, jak i somatyczne. XXI wiek okazał się być czasem, w którym depresja stała się realnym zagrożeniem dla zdrowia nie tylko poszczególnych jednostek, ale także całych społeczeństw. Istnieje wiele teorii wskazujących na przyczyny występowania depresji, jednak te bezpośrednie podłoża nadal nie są ostatecznie uznane jako całkowicie klarowne. Wskazuje się na równoznaczną istotność czynników neuroanatomicznych oraz psychologiczno-społecznych. Wśród rozpatrywanych dotychczasowo teorii można wyróżnić biologiczną, hormonalną, związaną z neuroprzekaźnikami, opisującą wadliwe funkcjonowania układu limbicznego i podwzgórza, teorie psychologiczne. Z przeprowadzonych dotychczas badań wynika, iż niezwykle istotną rolę w etiologii depresji odgrywają czynniki psychospołeczne. Objawy depresji są bardzo złożone i wielopłaszczyznowe, mogące posiadać różny stopień nasilenia. W wyniku badań dotyczących czynników ryzyka występowania depresji wykazano zależność pomiędzy niedoborem poszczególnych składników pokarmowych a ujawnianiem się zaburzeń depresyjnych. Celem pracy jest przedstawienie wpływu poszczególnych składników pokarmowych na występowanie i przebieg depresji. Właściwie zbilansowana dieta, zarówno pod kątem ilościowym, jak i jakościowym, wywiera pozytywny wpływ na zmniejszenie ryzyka wystąpienia depresji, a także poprawienie stanu osób, które już na nią cierpią. Wśród składników odżywczych, które mają tu szczególne znaczenie, znajdują się witamina D, magnez, kwas foliowy, tryptofan, cynk, kwasy tłuszczowe omega-3, kobalamina, niektóre drobnoustroje probiotyczne

Influence of vegetarian diet on human body

All over the world there are more vegetarians than in previous years due to many reasons. One of them is positive influence on health what is shown in the latest research. The aim of the article is to review the influence of vegetarian diet on frequent diseases such as: hypertension, obesity,osteoporosis.An analysis of scientific papers from Pubmed and Google Scholar was performed, which most accurately described the issue of impact vegetarian diet on human health. The following keywords have been used in the search:Vegetarian, hypertension, obesity, osteoporosis:vegetarian, hypertension, obesity, osteoporosis.The researchers shown than vegetarians have lover systolic blood pressure  and diastolic blood pressure by 10 and 5 mmHg, they also lower overall mortality by 10-15%, risk of heart failure and by ~40%,  stroke by~35% and coronary events by 20%. Vegetarians also have statistically  lower body mass index. What’s more in this diet is more energy efficient thanks too low food energy density and helps keeping leptin on adequate level. Research has shown than vegetarians have lower mineral bone density than non-vegetarian, although some studies has shown that  risk of fractures in vegetarians and non-vegetarians was not affected by diet alternation. Based on the results of the studies above vegetarian diet contributes to lower blood pressure and preventing from cardiovascular diseases. It helps to avoid obesity and  to get rid of weights also doesn’t have negative impact on osteoporosis

Store-operated calcium entry contributes to abnormal Ca²⁺ signalling in dystrophic mdx mouse myoblasts

Sarcolemma damage and activation of various calcium channels are implicated in altered Ca2+ homeostasis in muscle fibres of both Duchenne muscular dystrophy (DMD) sufferers and in the mdx mouse model of DMD. Previously we have demonstrated that also in mdx myoblasts extracellular nucleotides trigger elevated cytoplasmic Ca2+ concentrations due to alterations of both ionotropic and metabotropic purinergic receptors. Here we extend these findings to show that the mdx mutation is associated with enhanced store-operated calcium entry (SOCE). Substantially increased rate of SOCE in mdx myoblasts in comparison to that in control cells correlated with significantly elevated STIM1 protein levels. These results reveal that mutation in the dystrophin-encoding Dmd gene may significantly impact cellular calcium response to metabotropic stimulation involving depletion of the intracellular calcium stores followed by activation of the store-operated calcium entry, as early as in undifferentiated myoblasts. These data are in agreement with the increasing number of reports showing that the dystrophic pathology resulting from dystrophin mutations may be developmentally regulated. Moreover, our results showing that aberrant responses to extracellular stimuli may contribute to DMD pathogenesis suggest that treatments inhibiting such responses might alter progression of this lethal disease

Formation and tribology of fucoidan/chitosan polyelectrolyte multilayers on PDMS substrates

Polysaccharide polyelectrolyte multilayers (PEMs) based on fucoidan and chitosan were formed by Layer-by-Layer (LbL) assembly on polydimethylsiloxane (PDMS) substrates. The surface and aqueous lubrication properties of the PEM films are evaluated for two types of fucoidan extracted from separate seaweed species (Fucus vesiculosus – FV and Undaria pinnatifida – UP). Zeta potential and atomic force microscopy (AFM) imaging reveal that the PEM layers are formed with consistent charge reversal as each polysaccharide layer is adsorbed to the PDMS substrate, and that there is an associated increase in thickness of the multilayer. The multilayers containing FV fucoidan are found to be thicker than those containing UP fucoidan. Soft tribology measurements using matching PDMS tribo-pairs are used to show that the films are robust under rolling/sliding contacts and effective under aqueous lubricating conditions. The friction in the boundary lubrication regime is substantially decreased (relative to native hydrophobic PDMS) by the presence of the multilayers, with some dependence on whether fucoidan or chitosan is in the outer layer (5 or 5.5 bilayers) for FV fucoidan. The lowest friction coefficient is obtained for the multilayer with the thickest (and likely most hydrated) coating – the (FV/chitosan) 5.5 bilayer system. The results suggest that PEMs involving naturally derived polysaccharides such as fucoidan, which has notable antimicrobial properties and is resistant to enzymatic degradation, may provide opportunities in surface coating design in biomaterials applications for friction reduction

Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study

Objectives. Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations.Methods. SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses.Results. The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP.AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001].Conclusion. Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality

The unusual surface chemistry of α-Al2O3 (0001)

We report on the influence of heat treatment on the surface chemistry of an α-alumina crystal. We compare its electrical double layer behaviour with that of 150 nm diameter α-Al2O3 particles. Surface spectroscopy and zeta potential studies are used to understand the changes in surface chemistry. The pHpzc of an α-Al2O3 (0001) single crystal ([similar]4) is more acidic than that of α-Al2O3 particles (8.5), a difference explained by the dominance of [triple bond, length as m-dash]Al2OH surface groups on the single crystals and their charging behaviour. Heat treatment of the alumina surface causes a substantial decrease in the number of surface OH groups. Heating at 500 °C decreases the surface density of hydroxyl groups. Heating at 1050 °C also affects surface morphology and surface chemistry. The increased magnitude of the zeta potential and the pHpzc shift to lower pH suggest a surface reconstruction and the appearance of more acidic aluminium sites.

Electrostatic attraction between a hydrophilic solid and a bubble

The contact between fine hydrophilic α-Al2O3 particles and nitrogen bubbles was studied as a function of solution composition in single bubble capture experiments, where the bubble collection efficiency was measured. The surface charges of both bubble and particle were controlled by varying the electrolyte concentration and pH of the solution. In all experiments the bubbles were negatively charged while the α-Al2O3 particles were either negatively (above pH of the isoelectric point, pHIEP) or positively (below pHIEP) charged. The collection efficiency was found to be strongly influenced by the surface charge of the particles. The maximum collection efficiency occurred when the bubble and particle were oppositely charged (at low pH values) and at low salt concentration, i.e. when a long range attractive electrostatic interaction is present. In the case where both bubble and particle were of the same charge, the collection efficiency was near to zero within experimental error and was not influenced by either salt concentration or pH. This is the first experimental proof of the concept of ‘contactless flotation’, first proposed by Derjaguin and Dukhin in 1960, with far reaching implications from minerals processing to biology.