Tratamiento psicológico en el trastorno de somatización : eficacia y propuestas de intervención

This review analyze randomized controlled studies carried out both in somatization disorder and in undifferentiated somatoform disorder patients that had been treated using two kind of interventions: 1. A consultation letter referred by a mental health specialist to the patient's family doctor and 2. Using cognitive-behaviour therapy. In these studies some variables such as the setting, the content, the number of sessions, the outcome, the foUow-up, etc. has been assessed. We summarize the main conclusions on psychological interventions developed up to the moment in these patients and we propose new stepped cognitive-behavioural therapies to implement in the future in somatization disorder patients.Este trabajo de revisión analiza los estudios controlados randomizados realizados tanto en pacientes con trastorno de somatización como en pacientes con trastorno somatomorfo indiferenciado que han sido tratados mediante dos tipos de intervenciones: 1. Mediante la remisión de una carta de interconsulta por parte de un especialista de salud mental a atención primaria y 2. mediante terapia cognitivo-conductual. En estos estudios se analizan variables como el entorno, el contenido de la terapia, el formato, el número de sesiones, las variables de resultado, el tiempo de seguimiento, etc. Se resumen las principales conclusiones de las intervenciones psicológicas realizadas hasta el momento en estos pacientes y se realizan propuestas para nuevos terapias cognitivo- conductuales en escalado a realizar en el futuro en pacientes con trastorno de somatización

The Adoption of Digital fashion as an End-product: A Systematic Literature Review of Research Foci and Future Research Agenda

With the advancement of 3D design software, “digital fashion” has evolved from a retail and design tool for physical fashion to a virtual-only end-product sold to consumers in wholly digital form. As many brands are now developing digital fashion end products as a new revenue stream, given its potential to reduce some levels of overconsumption of physical clothing, it warrants academic attention. However, the literature has predominantly defined digital fashion as a tool rather than an end-product, resulting in an incomplete definition of digital fashion. This hinders scholars’ ability to fully comprehend and explore this emerging product category. This article aims to synthesize the current marketing/management literature on digital fashion and investigate the theories, context, characteristics, and methodology of digital fashion as an end-product. This study contributes to the literature by providing a comprehensive industry-accepted definition of digital fashion within a conceptual framework, categorizing six different types of digital fashion end-products, and establishing a future research agenda that will lead to new research streams

Validation of living with chronic illness scale in a type 2 diabetes mellitus population

Background: Worldwide, type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic diseases and one of those producing greatest impact on patients’ day-to-day quality of life. Our study aim is to validate the “Living with Chronic Illness Scale” for a Spanish-speaking T2DM population. Methods: In this observational, international, cross-sectional study, 582 persons with T2DM were recruited in primary care and outpatient hospital consultations, in Spain and Colombia, during the period from May 2018 to June 2019. The properties analysed were feasibility/acceptability, internal consistency, reliability, precision and (structural) content-construct validity including confrmatory factor analysis. The COSMIN checklist was used to assess the methodological/psychometric quality of the instrument. Results: The scale had an adequate internal consistency and test retest reliability (Cronbach’s alpha=0.90; intraclass correlation coefcient=0.96, respectively). In addition, the instrument is precise (standard error of measurement=3.34, with values<½SD=8.52) and correlates positively with social support (DUFSS) (rs=0.56), quality of life (WHOQOL-BREF) (rs=0.51–0.30) and ssatisfaction with life (SLS-6) (rs=0.50–0.38). The original 26-items version of the scale did not support totally the confrmatory factor analysis. The COSMIN checklist is favourable for all the properties analysed, although weaknesses are detected for structural validity. Conclusions: The LW-CI-T2DM is a valid, reliable and accurate instrument for use in clinical practice to determine how a person’s life is afected by the presence of diabetes. This instrument correlates well with the associated constructs of social support, quality of life and satisfaction. Additional research is needed to determine how well the questionnaire structure performs when robust factor analysis methods are applied.This study has been funded by the Ministry of Science, Innovation and University of the Spanish Government (FEDER/Ministerio de Ciencia, Innovación y Universidades-Agencia Estatal de Investigación/ Proyecto (CSO2017-82691-R)).S

Osteoprotegerin in Exosome-Like Vesicles from Human Cultured Tubular Cells and Urine

Urinary exosomes have been proposed as potential diagnostic tools. TNF superfamily cytokines and receptors may be present in exosomes and are expressed by proximal tubular cells. We have now studied the expression of selected TNF superfamily proteins in exosome-like vesicles from cultured human proximal tubular cells and human urine and have identified additional proteins in these vesicles by LC-MS/MS proteomics. Human proximal tubular cells constitutively released exosome-like vesicles that did not contain the TNF superfamily cytokines TRAIL or TWEAK. However, exosome-like vesicles contained osteoprotegerin (OPG), a TNF receptor superfamily protein, as assessed by Western blot, ELISA or selected reaction monitoring by nLC-(QQQ)MS/MS. Twenty-one additional proteins were identified in tubular cell exosomelike vesicles, including one (vitamin D binding protein) that had not been previously reported in exosome-like vesicles. Twelve were extracellular matrix proteins, including the basement membrane proteins type IV collagen, nidogen-1, agrin and fibulin-1. Urine from chronic kidney disease patients contained a higher amount of exosomal protein and exosomal OPG than urine from healthy volunteers. Specifically OPG was increased in autosomal dominant polycystic kidney disease urinary exosome-like vesicles and expressed by cystic epithelium in vivo. In conclusion, OPG is present in exosome-like vesicles secreted by proximal tubular epithelial cells and isolated from Chronic Kidney Disease urine.This work was supported by grants from the Instituto de Salud Carlos III (ISCIIIRETIC REDINREN RD06/0016, RD12/0021, PI11/01854, PI10/00072 PI09/ 00641 and PS09/00447); Comunidad de Madrid (Fibroteam S2010/BMD-2321, S2010/BMD-2378); Sociedad Española de NefrologÍa; European Network (HEALTH F2-2008-200647); DIALOK European project LSHB-CT-2007-036644; Fundacion Lilly and IRSIN/FRIAT to JE; Programa Intensificación Actividad Investigadora (ISCIII/ Agencia Laín-Entralgo/CM) to AO; Instituto de Salud Carlos III (FIS PI11/01401, CP09/00229); and Fundación Conchita Rábago de Jiménez DÍaz to GAL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscrip

Pru p 3 acts as a strong sensitizer for peanut allergy in Spain

Pru p 3 has been suggested to be the primary sensitizing allergen in patients with peanut allergy in the Mediterranean area. We aimed to confirm this hypothesis, studying 79 subjects