Identificat el receptor de la relaxació del còlon

Un grup d'investigadors del Departament de Biologia Cel·lular, Fisiologia e Immunologia i de l'Institut de Neurociències de la UAB han confirmat que el receptor P2Y1 és responsable de la relaxació del còlon. Una recerca prèviament realitzada a la UAB en mostres de colon humà, ha estat confirmada en aquest estudi amb un ratolí genèticament modificat que no té el receptor i per tant el colon no es relaxa. Futurs estudis permetran valorar la funció del receptor en diferents patologies.Un grupo de investigadores del Departamento de Biología Celular, Fisiología e Inmunología y del Instituto de Neurociencias de la UAB han confirmado que el receptor P2Y1 es responsable de la relajación del colon. Una investigación previamente realizada en la UAB en muestras de colon humano, ha sido confirmada en este estudio con ratón genéticamente modificado que no tiene el receptor y por tanto el colon del cual no se relaja. Futuros estudios permitirán valorar la función del receptor en diferentes patologías

Mechanisms responsible for neuromuscular relaxation in the gastrointestinal tract

The enteric nervous system (ENS) is responsible for the genesis of motor patterns ensuring an appropriate intestinal transit. Enteric motor neurons are classified into afferent neurons, interneurons and motorneurons. Motorneurons are excitatory or inhibitory causing smooth muscle contraction and relaxation respectively. Muscle relaxation mechanisms are key for the understanding of physiological processes such as sphincter relaxation, gastric accommodation, or the descending phase of the peristaltic reflex. Nitric oxide (NO) and ATP or a related purine are the primary inhibitory neurotransmitters. Nitrergic neurons synthesize NO through nNOS enzyme activity. NO diffuses across the cell membrane to bind guanylyl cyclase, and then activates a number of intracellular mechanisms that ultimately result in muscle relaxation. ATP is an inhibitory neurotransmitter together with NO. The P2Y1 receptor has been identified as a the purine receptor responsible for smooth muscle relaxation. Although, probably, no clinician doubts about the significance of NO in the pathophysiology of gastrointestinal motility, the relevance of purinergic neurotransmission is apparently much lower, as ATP has not been associated with any specific motor dysfunction yet. The goal of this review is to discuss the function of both relaxation mechanisms in order to establish the physiological grounds of potential motor dysfunctions arising from impaired intestinal relaxation

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present