Influencia de la adherencia a la Dieta Mediterránea y el estado nutricional en la reserva ovárica: Estudio piloto transversal

Introducción: Actualmente, la esterilidad afecta a entre el 15% y 20% de las parejas en edad fértil. El éxito reproductivo femenino está determinado fundamentalmente por la edad y la reserva ovárica (RO). Recientes estudios remarcan la influencia de factores modificables como los hábitos dietéticos y el estado nutricional en la RO. A este respecto, la Dieta Mediterránea (DM) se postula como un estándar de alimentación saludable. Objetivo: Analizar la influencia del grado de adherencia a la DM y el estado nutricional en la RO de mujeres estériles. Metodología: Se efectuó un estudio descriptivo transversal en una muestra de 40 pacientes de sexo femenino que acudieron a la consulta de Ginecología-Esterilidad en el Hospital Marina Salud de Denia (España) por deseo genésico de más de un año de evolución. Resultados: No se encontró asociación entre el grado de adherencia a la DM y el estado de la RO. No obstante, se determinó una asociación estadísticamente significativa entre el bajo consumo de verduras y hortalizas e insuficientes niveles de hormona antimülleriana (AMH; p=0,015) y estradiol (p=0,049), así como niveles elevados de la hormona folículo estimulante (p=0,024), indicativos de baja RO. También se observó que el consumo diario de carne roja estaba asociado con bajos niveles de AMH (p=0,007). Asimismo, se encontraron novedosas asociaciones estadísticamente significativas que reflejaban la influencia del estado nutricional en la RO. Conclusión: el estado nutricional y hábitos dietéticos como el bajo consumo de verduras y hortalizas se asocian a alteraciones en la RO

Assessment of Nutritional Status and Its Influence on Ovarian Reserve: A Systematic Review

Background: Nowadays, there is a growing interest in the relationship among lifestyle, reproductive health, and fertility. Recent investigations highlight the influence of environmental and lifestyle factors such as stress, diet, and nutritional status on reproductive health. The aim of this review was to determine the influence of nutritional status on ovarian reserve in order to improve the reproductive health of women of childbearing age. Methods: A systematic literature review was carried out following the PRISMA method. The quality of the studies was assessed using the Cochrane Collaboration Risk of Bias tool. Data were extracted, and the results were summarized into two blocks: according to the technique used to assess ovarian reserve and nutritional status; according to the results found in the relationship between ovarian reserve and nutritional status. Results: A total of 22 articles involving 5929 women were included. In 12 of the included articles (54.5%), a relationship between nutritional status and ovarian reserve was demonstrated. In seven publications (31.8%), the increased body mass index (BMI) led to a decrease in ovarian reserve, two of them (0.9%) in patients with polycystic ovary syndrome, showing a decrease only if BMI > 25. In two articles (0.9%), there was a negative relationship between ovarian reserve and waist-to-hip ratio, and in one (0.45%), a positive relationship was shown between ovarian reserve and testosterone levels, the latter being related to body mass index. In five articles (22.7%), body mass index was used as a confounder and was negatively related to ovarian reserve, and in another four (18%), no correlation was found. Conclusions: Ovarian reserve appears to be influenced by nutritional status. A high body mass index has a negative impact on the ovary, decreasing antral follicle count and anti-Müllerian hormone. Oocyte quality is compromised, increasing the rate of reproductive problems and the demand for assisted reproductive techniques. Further studies are needed to understand which dietary factors have the greatest effect on ovarian reserve in order to promote reproductive health

Influence of the Mediterranean diet on seminal quality—a systematic review

Currently, there is a growing interest in the study of fertility because fertility-related problems affect up to 15% of the world’s population. The aim of this study was to determine the influence of the Mediterranean diet on seminal quality in men of reproductive age. For this purpose, a systematic review of the literature was carried out following the PRISMA method. Electronic searches were carried out in the international databases PubMed, Scopus, the Cochrane Library, and Web of Science. In total, 10 articles with 2032 men were included. As inclusion criteria, articles published between 2012 and 2022 were selected, including those that included men aged between 18 and 55 years. Nutritional status was assessed through weight, height, and BMI. Dietary habits were evaluated through different indexes and food frequency questionnaires, and finally, semen quality was evaluated by measuring sperm concentration and motility (progressive and non-progressive). In six (60%) of the included articles, a positive relationship between adherence to the Mediterranean diet and semen quality was demonstrated; in two (20%) of the articles, no association was found; and finally, in two (20%) of the included articles, the relationship between dietary patterns typical of DM and semen quality was evaluated. Dietary habits influence semen quality. Adherence to the Mediterranean diet can improve male reproductive health, as it is a diet with antioxidant and anti-inflammatory effects. This is the first systematic review about the influence of the Mediterranean diet on semen quality, and the results are positive. These findings may allow us to provide better advice to our patients and to establish interventions with the aim of improving the results of assisted reproduction techniques

The importance of nutrition in the prevention of endometriosis: systematic review

Antecedentes y objetivo: la endometriosis es un trastorno dependiente de hormonas que se caracteriza por la presencia de tejido similar al endometrial en sitios extrauterinos, lo que puede desencadenar una reacción inflamatoria crónica. Esta enfermedad afecta principalmente a mujeres en edad fértil y puede tener un impacto negativo en su bienestar físico, mental y social. Existen patrones alimentarios considerados antiinflamatorios, como el de dieta mediterránea, que podrían ayudar en la prevención y el tratamiento de la endometriosis. El objetivo de esta revisión fue conocer la relación entre el consumo de diferentes grupos de alimentos y la prevención de la endometriosis. Materiales y métodos: se realizó una revisión sistemática siguiendo la metodología PRISMA. Se consultaron las bases de datos PubMed, Scopus, Cochrane Library y Web of Science. Se seleccionaron estudios publicados entre 2013 y 2023, que fueran accesibles en texto completo, escritos en inglés y español y que incluyeran una muestra de mujeres con endometriosis y/o mujeres sanas, además de evaluar la relación entre la alimentación y la endometriosis. Se excluyeron artículos no relacionados, revisiones sistemáticas o metaanálisis y estudios piloto y realizados en animales. Resultados: se incluyeron diez estudios en total. El consumo de frutas, verduras (no crucíferas), lácteos, pescados, patatas, legumbres, vitaminas (A, C, D y B12), ácidos grasos monoinsaturados y poliinsaturados y minerales (calcio, potasio y magnesio) parece reducir el riesgo de endometriosis. Conclusiones: se necesitan más estudios que investiguen la relación entre el consumo de los diferentes grupos de alimentos y el riesgo de endometriosis.Background and objective: endometriosis is a hormone-dependent disorder characterized by the presence of endometrial-like tissue in extrauterine sites, which can trigger a chronic inflammatory reaction. This disease mainly affects women of childbearing age and can have a negative impact on their physical, mental and social well-being. There are eating patterns considered as anti-inflammatory, such as the Mediterranean diet, which could help in the prevention and treatment of endometriosis. The objective of this review was to know the relationship between the consumption of different food groups and the prevention of endometriosis. Materials and methods: a systematic review was carried out following the PRISMA methodology. PubMed, Scopus, Cochrane Library and Web of Science databases were consulted. Studies published between 2013 and 2023 were selected, accessible in full text, written in English and Spanish and including a sample of women with endometriosis and/or healthy women, in addition to evaluating the relationship between diet and endometriosis. Unrelated articles, systematic reviews or meta-analyses, pilot studies and studies conducted in animals were excluded. Results: a total of ten studies were included. The consumption of fruits, vegetables (not cruciferous), dairy products, fish, potatoes, legumes, vitamins (A, C, D and B12), monounsaturated and polyunsaturated fatty acids and minerals (calcium, potassium and magnesium) seems to reduce the risk of endometriosis. Conclusions: further studies investigating the relationship between consumption of different food groups and risk of endometriosis are needed

Thermally reduced graphene is a permissive material for neurons and astrocytes and de novo neurogenesis in the adult olfactory bulb in vivo

Graphene and graphene-based nanomaterials (GBNs) are being investigated as potential substrates for the growth of neural stem cells (NSCs), neurons and glia in cell culture models. In contrast, reports testing the effects of graphene directly with adult neural cells in vivo are missing. Here we studied the biocompatibility of thermally reduced graphene (TRG) with neurons and glia, as well as with the generation of new neurons in the adult brain in vivo. TRG injected in the brain together with a retroviral vector expressing GFP to label dividing progenitor cells in the core of the adult olfactory bulb (OB) did not alter de novo neurogenesis, neuronal and astrocyte survival nor did it produce a microglial response. These findings indicate that TRG may be a biocompatible material with neuronal and glial cells in vivo and support its use in studies of brain repair and function.We are grateful to M.J. Roman for her technical support. This work was funded by grants from the European Union in the 7th Framework Program research project “HARCANA” (Grant Agreement No. NMP3-LA-2008-213277) to M.A.L.-M. and C.V.-A, the Spanish Ministerio de Economía y Competitividad (MINECO: CIBERNED CB06/05/0065, SAF2013-47596R, and CSIC 201220E098) to C.V.-A, from the Spanish Ministry of Science and Innovation (MiCInn: MAT 2010e18749) to R.V, from MINECO (SAF2010-15173) to R. M.-M, and from MINECO (BFU2011-26339) and INCRECyT project from European Social Fund, PCyTA and JCCM to E.D.M.Peer Reviewe

La pizarra digital como ayuda y apoyo a la pizarra tradicional

La Pizarra Digital Interactiva supone un recurso tecnológico consistente en un ordenador multimedia conectado a la intranet del centro y a internet y a un proyector que se refleja en una pantalla interactiva de gran tamaño. Es un recurso didáctico que mejora la interactividad y la motivación de los alumnos. Se marcan como objetivos usar la Pizarra Digital en el proceso cotidiano de enseñanza-aprendizaje; establecer un catálogo de utilidades de la pizarra diferenciado por niveles y áreas de conocimiento; presentar la información en recursos multimedia y elaborar documentos adaptados a las necesidades del centro. Además, con esta herramienta se facilita el intercambio de información y experiencias; y se logra un mayor y mejor acceso de los alumnos a los recursos que ofrecen las nuevas tecnologías. En cuanto a las actividades, se organizan cursos, seminarios y ponencias sobre tecnología educativa; se realiza una revisión del proyecto educativo del centro y de los proyectos curriculares de cada etapa; se realiza un inventario de los recursos referidos a las tecnologías de la información y a la comunicación de los que se dispone en el centro; se realizan reuniones periódicas para compartir experiencias de los docentes; se crean nuevo recursos multimedia adaptados; y se recopila nuevo material didáctico. Incluye DVD con los materiales elaborados.Madrid (Comunidad Autónoma). Consejería de Educación. Dirección General de Ordenación AcadémicaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES