Formation of Relativistic Axion Stars

Axions and axion-like particles are compelling candidates for the missing dark matter of the universe. As they undergo gravitational collapse, they can form compact objects such as axion stars or even black holes. In this paper, we study the formation and distribution of such objects. First, we simulate the formation of compact axion stars using numerical relativity with aspherical initial conditions that could represent the final stages of axion dark matter structure formation. We show that the final states of such collapse closely follow the known relationship of initial mass and axion decay constant $f_a$. Second, we demonstrate with a toy model how this information can be used to scan a model density field to predict the number densities and masses of such compact objects. In addition to being detectable by the LIGO/VIRGO gravitational wave interferometer network for axion mass of $10^{-9} < m_a < 10^{-11}$ eV, we show using peak statistics that for $f_a < 0.2M_{pl}$, there exists a "mass gap" between the masses of axion stars and black holes formed from collapse

The True Incidence of Magnetism among Field White Dwarfs

We study the incidence of magnetism in white dwarfs from three large and well-observed samples of hot, cool, and nearby white dwarfs in order to test whether the fraction of magnetic degenerates is biased, and whether it varies with effective temperature, cooling age, or distance. The magnetic fraction is considerably higher for the cool sample of Bergeron, Ruiz, and Leggett, and the Holberg, Oswalt, and Sion sample of local white dwarfs that it is for the generally-hotter white dwarfs of the Palomar Green Survey. We show that the mean mass of magnetic white dwarfs in this survey is 0.93 solar masses or more, so there may be a strong bias against their selection in the magnitude-limited Palomar Green Survey. We argue that this bias is not as important in the samples of cool and nearby white dwarfs. However, this bias may not account for all of the difference in the magnetic fractions of these samples. It is not clear that the magnetic white dwarfs in the cool and local samples are drawn from the same population as the hotter PG stars. In particular, two or threee of the cool sample are low-mass white dwarfs in unresolved binary systems. Moreover, there is a suggestion from the local sample that the fractional incidence may increase with decreasing temperature, luminosity, and/or cooling age. Overall, the true incidence of magnetism at the level of 2 megagauss or greater is at least 10%, and could be higher. Limited studies capable of detecting lower field strengths down to 10 kilogauss suggest by implication that the total fraction may be substantially higher than 10%.Comment: 16 pages, 2 figures, Astronomical Journal in press -- Jan 2003 issu

Towards Better Integrators for Dissipative Particle Dynamics Simulations

Coarse-grained models that preserve hydrodynamics provide a natural approach to study collective properties of soft-matter systems. Here, we demonstrate that commonly used integration schemes in dissipative particle dynamics give rise to pronounced artifacts in physical quantities such as the compressibility and the diffusion coefficient. We assess the quality of these integration schemes, including variants based on a recently suggested self-consistent approach, and examine their relative performance. Implications of integrator-induced effects are discussed.Comment: 4 pages, 3 figures, 2 tables, accepted for publication in Phys. Rev. E (Rapid Communication), tentative publication issue: 01 Dec 200

The Formation Rate, Mass and Luminosity Functions of DA White Dwarfs from the Palomar Green Survey

Spectrophotometric observations at high signal-to-noise ratio were obtained of a complete sample of 347 DA white dwarfs from the Palomar Green (PG) Survey. Fits of observed Balmer lines to synthetic spectra calculated from pure-hydrogen model atmospheres were used to obtain robust values of Teff, log g, masses, radii, and cooling ages. The luminosity function of the sample, weighted by 1/Vmax, was obtained and compared with other determinations. The mass distribution of the white dwarfs is derived, after important corrections for the radii of the white dwarfs in this magnitude-limited survey and for the cooling time scales. The formation rate of DA white dwarfs from the PG is estimated to be 0.6x10^(-12) pc^(-3) yr^(-1). Comparison with predictions from a theoretical study of the white dwarf formation rate for single stars indicates that >80% of the high mass component requires a different origin, presumably mergers of lower mass double degenerate stars. In order to estimate the recent formation rate of all white dwarfs in the local Galactic disk, corrections for incompleteness of the PG, addition of the DB-DO white dwarfs, and allowance for stars hidden by luminous binary companions had to be applied to enhance the rate. An overall formation rate of white dwarfs recently in the local Galactic disk of 1.15+/-0.25x10^(-12) pc^(-3) yr^(-1) is obtained. Two recent studies of samples of nearby Galactic planetary nebulae lead to estimates around twice as high. Difficulties in reconciling these determinations are discussed.Comment: 73 pages, 18 figures, accepted for publication in the ApJ Supplemen

IPD—the Immuno Polymorphism Database

The Immuno Polymorphism Database (IPD) (http://www.ebi.ac.uk/ipd/) is a set of specialist databases related to the study of polymorphic genes in the immune system. IPD currently consists of four databases: IPD-KIR, contains the allelic sequences of Killer-cell Immunoglobulin-like Receptors; IPD-MHC, a database of sequences of the Major Histocompatibility Complex of different species; IPD-HPA, alloantigens expressed only on platelets; and IPD-ESTAB, which provides access to the European Searchable Tumour Cell-Line Database, a cell bank of immunologically characterized melanoma cell lines. The IPD project works with specialist groups or nomenclature committees who provide and curate individual sections before they are submitted to IPD for online publication. The IPD project stores all the data in a set of related databases. Those sections with similar data, such as IPD-KIR and IPD-MHC share the same database structure. The sharing of a common database structure makes it easier to implement common tools for data submission and retrieval. The data are currently available online from the website and ftp directory; files will also be made available in different formats to download from the website and ftp server. The data will also be included in SRS, BLAST and FASTA search engines at the European Bioinformatics Institute

Molecular regulation of GLUT-4 targeting in 3T3-L1 adipocytes

Insulin stimulates glucose transport in muscle and adipose tissue by triggering the movement of the glucose transporter GLUT-4 from an intracellular compartment to the cell surface. Fundamental to this process is the intracellular sequestration of GLUT-4 in nonstimulated cells. Two distinct targeting motifs in the amino and carboxy termini of GLUT-4 have been previously identified by expressing chimeras comprised of portions of GLUT-4 and GLUT-1, a transporter isoform that is constitutively targeted to the cell surface, in heterologous cells. These motifs-FQQ1 in the NH terminus and LL in the COOH terminus-resemble endocytic signals that have been described in other proteins. In the present study we have investigated the roles of these motifs in GLUT-4 targeting in insulin-sensitive cells. Epitope-tagged GLUT-4 constructs engineered to differentiate between endogenous and transfected GLUT-4 were stably expressed in 3T3-L1 adipocytes. Targeting was assessed in cells incubated in the presence or absence of insulin by subcellular fractionation. The targeting of epitope-tagged GLUT-4 was indistinguishable from endogenous GLUT-4. Mutation of the FQQI motif (F to A) caused GLUT-4 to constitutively accumulate at the cell surface regardless of expression level. Mutation of the dileucine motif (LL to AA) caused an increase in cell surface distribution only at higher levels of expression, but the overall cell surface distribution of this mutant was less than that of the amino-terminal mutants. Both NH- and COOH-terminal mutants retained insulin-dependent movement from an intracellular to a cell surface locale, suggesting that neither of these motifs is involved in the insulin-dependent redistribution of GLUT-4. We conclude that the phenylalanine-based NH-terminal and the dileucine-based COOH-terminal motifs play important and distinct roles in GLUT-4 targeting in 3T3-L1 adipocytes

A Spatially Resolved `Inside-out' Outburst of IP Pegasi

We present a comprehensive photometric dataset taken over the entire outburst of the eclipsing dwarf nova IP Peg in September/October 1997. Analysis of the lightcurves taken over the long rise to the peak-of-outburst shows conclusively that the outburst started near the centre of the disc and moved outwards. This is the first dataset that spatially resolves such an outburst. The dataset is consistent with the idea that long rise times are indicative of such `inside-out' outbursts. We show how the thickness and the radius of the disc, along with the mass transfer rate change over the whole outburst. In addition, we show evidence of the secondary and the irradiation thereof. We discuss the possibility of spiral shocks in the disc; however we find no conclusive evidence of their existence in this dataset.Comment: 8 pages, 8 figures, to be appear in MNRA

Risk of SARS-CoV-2 Transmission During Flexible Laryngoscopy: A Systematic Review.

IMPORTANCE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reportedly infected otolaryngologists disproportionately in the early parts of the coronavirus disease 2019 pandemic. Recommendations from national and international health organizations suggest minimizing the use of flexible laryngoscopy as a result. OBJECTIVE: To review evidence on the risks of aerosolization and transmission of SARS-CoV-2 from patients to health care personnel during endoscopy of the upper aerodigestive tract. EVIDENCE REVIEW: A comprehensive review of literature was performed on April 19, 2020, using the PubMed/MEDLINE (1966-April 2020), Embase (1975-April 2020), and Web of Science (1900-April 2020) databases. All English-language primary research studies were included if they assessed the transmission of SARS-CoV-2 or SARS-CoV-1 during procedures in the upper aerodigestive tract. The primary outcome measure was disease transmission among health care workers. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used for accuracy of reporting. FINDINGS: The queries for SARS-CoV-2 and SARS-CoV-1 identified 6 articles for systematic review. No studies included in this review provided data for SARS-CoV-2 transmission during flexible laryngoscopy. A total of 204 of 1264 health care workers (16.1%) had procedure-specific infections of SARS-CoV-1 or SARS-CoV-2. Among those, 53 of 221 (24.0%) were exposed during intubation, 1 of 15 (6.7%) during bronchoscopy, and 1 of 1 (100%) during endoscopy-assisted intubation. CONCLUSIONS AND RELEVANCE: A substantial lack of research precludes formal conclusions about the safety of flexible laryngoscopy and transmission of SARS-CoV-2 from patients to health care workers. The use of appropriate precautionary measures and personal protective equipment appears to reduce the risk of transmission. Given the uncertainty in transmission and the known benefits of safety precautions, upper airway endoscopy may be reasonable to perform if precautionary steps are taken

Defining childhood severe falciparum malaria for intervention studies.

Background Clinical trials of interventions designed to prevent severe falciparum malaria in children require a clear endpoint. The internationally accepted definition of severe malaria is sensitive, and appropriate for clinical purposes. However, this definition includes individuals with severe nonmalarial disease and coincident parasitaemia, so may lack specificity in vaccine trials. Although there is no “gold standard” individual test for severe malaria, malaria-attributable fractions (MAFs) can be estimated among groups of children using a logistic model, which we use to test the suitability of various case definitions as trial endpoints. Methods and Findings A total of 4,583 blood samples were taken from well children in cross-sectional surveys and from 1,361 children admitted to a Kenyan District hospital with severe disease. Among children under 2 y old with severe disease and over 2,500 parasites per microliter of blood, the MAFs were above 85% in moderate- and low-transmission areas, but only 61% in a high-transmission area. HIV and malnutrition were not associated with reduced MAFs, but gastroenteritis with severe dehydration (defined by reduced skin turgor), lower respiratory tract infection (clinician's final diagnosis), meningitis (on cerebrospinal fluid [CSF] examination), and bacteraemia were associated with reduced MAFs. The overall MAF was 85% (95% confidence interval [CI] 83.8%–86.1%) without excluding these conditions, 89% (95% CI 88.4%–90.2%) after exclusions, and 95% (95% CI 94.0%–95.5%) when a threshold of 2,500 parasites/μl was also applied. Applying a threshold and exclusion criteria reduced sensitivity to 80% (95% CI 77%–83%). Conclusions The specificity of a case definition for severe malaria is improved by applying a parasite density threshold and by excluding children with meningitis, lower respiratory tract infection (clinician's diagnosis), bacteraemia, and gastroenteritis with severe dehydration, but not by excluding children with HIV or malnutrition