2,662 research outputs found
On the Nature of the Peculiar Hot Star in the Young LMC Cluster NGC1818
The blue star reported in the field of the young LMC cluster NGC1818 by Elson
et al. (1998) has the wrong luminosity and radius to be a "luminous white
dwarf" member of the cluster. In addition, unless the effective temperature
quoted by the authors is a drastic underestimate, the luminosity is much too
low for it to be a cluster member in the post-AGB phase. Other possibilities,
including that of binary evolution, are briefly discussed. However, the
implication that the massive main sequence turnoff stars in this cluster can
produce white dwarfs (instead of neutron stars) from single-star evolution
needs to be reconsidered.Comment: 5 pages, no figures, Ap J Letters in pres
The True Incidence of Magnetism among Field White Dwarfs
We study the incidence of magnetism in white dwarfs from three large and
well-observed samples of hot, cool, and nearby white dwarfs in order to test
whether the fraction of magnetic degenerates is biased, and whether it varies
with effective temperature, cooling age, or distance. The magnetic fraction is
considerably higher for the cool sample of Bergeron, Ruiz, and Leggett, and the
Holberg, Oswalt, and Sion sample of local white dwarfs that it is for the
generally-hotter white dwarfs of the Palomar Green Survey. We show that the
mean mass of magnetic white dwarfs in this survey is 0.93 solar masses or more,
so there may be a strong bias against their selection in the magnitude-limited
Palomar Green Survey. We argue that this bias is not as important in the
samples of cool and nearby white dwarfs. However, this bias may not account for
all of the difference in the magnetic fractions of these samples.
It is not clear that the magnetic white dwarfs in the cool and local samples
are drawn from the same population as the hotter PG stars. In particular, two
or threee of the cool sample are low-mass white dwarfs in unresolved binary
systems. Moreover, there is a suggestion from the local sample that the
fractional incidence may increase with decreasing temperature, luminosity,
and/or cooling age. Overall, the true incidence of magnetism at the level of 2
megagauss or greater is at least 10%, and could be higher. Limited studies
capable of detecting lower field strengths down to 10 kilogauss suggest by
implication that the total fraction may be substantially higher than 10%.Comment: 16 pages, 2 figures, Astronomical Journal in press -- Jan 2003 issu
The Formation Rate, Mass and Luminosity Functions of DA White Dwarfs from the Palomar Green Survey
Spectrophotometric observations at high signal-to-noise ratio were obtained
of a complete sample of 347 DA white dwarfs from the Palomar Green (PG) Survey.
Fits of observed Balmer lines to synthetic spectra calculated from
pure-hydrogen model atmospheres were used to obtain robust values of Teff, log
g, masses, radii, and cooling ages. The luminosity function of the sample,
weighted by 1/Vmax, was obtained and compared with other determinations. The
mass distribution of the white dwarfs is derived, after important corrections
for the radii of the white dwarfs in this magnitude-limited survey and for the
cooling time scales. The formation rate of DA white dwarfs from the PG is
estimated to be 0.6x10^(-12) pc^(-3) yr^(-1). Comparison with predictions from
a theoretical study of the white dwarf formation rate for single stars
indicates that >80% of the high mass component requires a different origin,
presumably mergers of lower mass double degenerate stars. In order to estimate
the recent formation rate of all white dwarfs in the local Galactic disk,
corrections for incompleteness of the PG, addition of the DB-DO white dwarfs,
and allowance for stars hidden by luminous binary companions had to be applied
to enhance the rate. An overall formation rate of white dwarfs recently in the
local Galactic disk of 1.15+/-0.25x10^(-12) pc^(-3) yr^(-1) is obtained. Two
recent studies of samples of nearby Galactic planetary nebulae lead to
estimates around twice as high. Difficulties in reconciling these
determinations are discussed.Comment: 73 pages, 18 figures, accepted for publication in the ApJ Supplemen
Molecular regulation of GLUT-4 targeting in 3T3-L1 adipocytes
Insulin stimulates glucose transport in muscle and adipose tissue by triggering the movement of the glucose transporter GLUT-4 from an intracellular compartment to the cell surface. Fundamental to this process is the intracellular sequestration of GLUT-4 in nonstimulated cells. Two distinct targeting motifs in the amino and carboxy termini of GLUT-4 have been previously identified by expressing chimeras comprised of portions of GLUT-4 and GLUT-1, a transporter isoform that is constitutively targeted to the cell surface, in heterologous cells. These motifs-FQQ1 in the NH terminus and LL in the COOH terminus-resemble endocytic signals that have been described in other proteins. In the present study we have investigated the roles of these motifs in GLUT-4 targeting in insulin-sensitive cells. Epitope-tagged GLUT-4 constructs engineered to differentiate between endogenous and transfected GLUT-4 were stably expressed in 3T3-L1 adipocytes. Targeting was assessed in cells incubated in the presence or absence of insulin by subcellular fractionation. The targeting of epitope-tagged GLUT-4 was indistinguishable from endogenous GLUT-4. Mutation of the FQQI motif (F to A) caused GLUT-4 to constitutively accumulate at the cell surface regardless of expression level. Mutation of the dileucine motif (LL to AA) caused an increase in cell surface distribution only at higher levels of expression, but the overall cell surface distribution of this mutant was less than that of the amino-terminal mutants. Both NH- and COOH-terminal mutants retained insulin-dependent movement from an intracellular to a cell surface locale, suggesting that neither of these motifs is involved in the insulin-dependent redistribution of GLUT-4. We conclude that the phenylalanine-based NH-terminal and the dileucine-based COOH-terminal motifs play important and distinct roles in GLUT-4 targeting in 3T3-L1 adipocytes
Towards Better Integrators for Dissipative Particle Dynamics Simulations
Coarse-grained models that preserve hydrodynamics provide a natural approach
to study collective properties of soft-matter systems. Here, we demonstrate
that commonly used integration schemes in dissipative particle dynamics give
rise to pronounced artifacts in physical quantities such as the compressibility
and the diffusion coefficient. We assess the quality of these integration
schemes, including variants based on a recently suggested self-consistent
approach, and examine their relative performance. Implications of
integrator-induced effects are discussed.Comment: 4 pages, 3 figures, 2 tables, accepted for publication in Phys. Rev.
E (Rapid Communication), tentative publication issue: 01 Dec 200
A Spatially Resolved `Inside-out' Outburst of IP Pegasi
We present a comprehensive photometric dataset taken over the entire outburst
of the eclipsing dwarf nova IP Peg in September/October 1997. Analysis of the
lightcurves taken over the long rise to the peak-of-outburst shows conclusively
that the outburst started near the centre of the disc and moved outwards. This
is the first dataset that spatially resolves such an outburst. The dataset is
consistent with the idea that long rise times are indicative of such
`inside-out' outbursts. We show how the thickness and the radius of the disc,
along with the mass transfer rate change over the whole outburst. In addition,
we show evidence of the secondary and the irradiation thereof. We discuss the
possibility of spiral shocks in the disc; however we find no conclusive
evidence of their existence in this dataset.Comment: 8 pages, 8 figures, to be appear in MNRA
In Vitro Gene Expression Dissected: Chemostat Surgery for Mycobacterium Tuberculosis
A unique approach, combining defined and reproducible in vitro models with DNA
microarrays, has been developed to study environmental modulation of mycobacterial
gene expression. The gene expression profiles of samples of Mycobacterium tuberculosis,
from independent chemostat cultures grown under defined and reproducible
conditions, were found to be highly correlated. This approach is now being used to
study the effect of relevant stimuli, such as limited oxygen availability, on mycobacterial
gene expression. A modification of the chemostat culture system, enabling largevolume
controlled batch culture, has been developed to study starvation survival.
Cultures of M. tuberculosis have been maintained under nutrient-starved conditions
for extended periods, with 106 â 107 bacilli surviving in a culturable state after
100 days. The design of the culture system has made it possible to control the environment
and collect multiple time-course samples to study patterns of gene expression.
These studies demonstrate that it is possible to perform long-term studies and obtain
reproducible expression data using controlled and defined in vitro models
The economic impact of periprosthetic infection in total hip arthroplasty
© 2020 Canadian Medical Association. All rights reserved. Background: Periprosthetic joint infection (PJI) is the third leading cause of total hip arthroplasty (THA) failure. Although controversial, 2-stage revision remains the gold standard treatment for PJI in most situations. To date, there have been few studies describing the economic impact of PJI in today\u27s health care environment. The purpose of the current study was to obtain an accurate estimate of the institutional cost associated with the management of PJI in THA and to assess the economic burden of PJI compared with primary uncomplicated THA. Methods: We conducted a review of primary THA cases and 2-stage revision THA for PJI at our institution. Patients were matched for age and body mass index. All costs associated with each procedure were recorded. Descriptive statistics were used to summarize the collected data. Mean costs, length of stay, clinic visits and readmission rates associated with the 2 cohorts were compared. Results: Fifty consecutive cases of revision THA were matched with 50 cases of uncomplicated primary THA between 2006 and 2014. Compared with the primary THA cohort, PJI was associated with a significant increase in mean length of hospital stay (26.5 v. 2.0 d, p \u3c 0.001), mean number of clinic visits (9.2 v. 3.8, p \u3c 0.001), number of readmissions (12 v. 1, p \u3c 0.001) and average overall cost (Can6764, t = 8.3, p \u3c 0.001). Conclusion: Treatment of PJI is a tremendous economic burden. Our data suggest a 5-fold increase in hospital expenditure in the management of PJI compared with primary uncomplicated THA
Evolving role of platelet function testing in coronary artery interventions
The substantial reduction in ischemic events provided by the dual antiplatelet regimen with aspirin and clopidogrel is well documented in patients with acute coronary syndrome and patients undergoing percutaneous coronary intervention. Recently the variable response to the antiplatelet agents has received considerable attention after several âboxed warningsâ on clopidogrel. This led to intense controversy on pharmacokinetic, pharmacodynamic, and pharmacogenomic issues of antiplatelet drugs, especially clopidogrel. Research use of platelet function testing has been successfully validated in identifying new antiplatelet drugs like prasugrel and ticagrelor. These platelet function assays are no longer regarded just as a laboratory phenomenon but rather as tools that have been shown to predict mortality in several clinical trials. It is believed that suboptimal response to an antiplatelet regimen (pharmacodynamic effect) may be associated with cardiovascular, cerebrovascular, and peripheral arterial events. There has been intense controversy about this variable response of antiplatelet drugs and the role of platelet function testing to guide antiplatelet therapy. While the importance of routine platelet function testing may be uncertain, it may be useful in high-risk patients such as those with diabetes mellitus, diffuse three vessels coronary artery disease, left main stenosis, diffuse atherosclerotic disease, and those with chronic renal failure undergoing percutaneous coronary intervention. It could also be useful in patients with suspected pharmacodynamic interaction with other drugs to assure the adequacy of platelet inhibition. While we wait for definitive trials, a predictive prognostic algorithm is necessary to individualize antiplatelet therapy with P2Y12 inhibitors based on platelet function assays and genetic testing
Effective dose coefficients for inhaled radon and its progeny: ICRPâs approach
The International Commission on Radiological Protection (ICRP) has recently published three reports on radon exposure: (i) Publication 115 on lung cancer risks from radon and radon progeny [1], (ii) Publication 126 on radiological protection against radon exposure [2] and (iii) Publication 137 on Occupational Intakes of Radionuclides (OIR), Part 3 [3]. The latter document gives doses coefficients for the inhalation of radon, thoron and their airborne progeny as well as recommendations for their use for the protection of workers. As with all other radionuclides, the effective dose coefficients are calculated with ICRP reference biokinetic and dosimetric models. Sufficient information and dosimetric data are given so that site-specific dose coefficients can be calculated based on measured aerosol parameter values
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