Roadmap toward the 10 ps time-of-flight PET challenge.

Since the seventies, positron emission tomography (PET) has become an invaluable medical molecular imaging modality with an unprecedented sensitivity at the picomolar level, especially for cancer diagnosis and the monitoring of its response to therapy. More recently, its combination with x-ray computed tomography (CT) or magnetic resonance (MR) has added high precision anatomic information in fused PET/CT and PET/MR images, thus compensating for the modest intrinsic spatial resolution of PET. Nevertheless, a number of medical challenges call for further improvements in PET sensitivity. These concern in particular new treatment opportunities in the context personalized (also called precision) medicine, such as the need to dynamically track a small number of cells in cancer immunotherapy or stem cells for tissue repair procedures. A better signal-to-noise ratio (SNR) in the image would allow detecting smaller size tumours together with a better staging of the patients, thus increasing the chances of putting cancer in complete remission. Moreover, there is an increasing demand for reducing the radioactive doses injected to the patients without impairing image quality. There are three ways to improve PET scanner sensitivity: improving detector efficiency, increasing geometrical acceptance of the imaging device and pushing the timing performance of the detectors. Currently, some pre-localization of the electron-positron annihilation along a line-of-response (LOR) given by the detection of a pair of annihilation photons is provided by the detection of the time difference between the two photons, also known as the time-of-flight (TOF) difference of the photons, whose accuracy is given by the coincidence time resolution (CTR). A CTR of about 10 picoseconds FWHM will ultimately allow to obtain a direct 3D volume representation of the activity distribution of a positron emitting radiopharmaceutical, at the millimetre level, thus introducing a quantum leap in PET imaging and quantification and fostering more frequent use of <sup>11</sup> C radiopharmaceuticals. The present roadmap article toward the advent of 10 ps TOF-PET addresses the status and current/future challenges along the development of TOF-PET with the objective to reach this mythic 10 ps frontier that will open the door to real-time volume imaging virtually without tomographic inversion. The medical impact and prospects to achieve this technological revolution from the detection and image reconstruction point-of-views, together with a few perspectives beyond the TOF-PET application are discussed

Extragalactic Submillimetric Surveys with BLAST

The Balloon-borne Large Aperture Submillimeter Telescope (BLAST) has recently conducted an extragalactic submillimetric survey of the Chandra Deep Field South region of unprecedented size, depth, and angular resolution in three wavebands centered at 250, 350, and 500 µm. BLAST wavelengths are chosen to study the Cosmic Infrared Background near its peak at 200 µm. We find that most of the CIB at these wavelengths is contributed by galaxies detected at 24 µm by the MIPS instrument on Spitzer, and that the source counts distribution shows a population with strongly evolving density and luminosity. These results anticipate what can be expected from the surveys that will be conducted with the SPIRE instrument on the Herschel space observatory

BLAST - The Balloon-borne Large Aperture Sub-millimeter Telescope

The balloon-borne large aperture sub-millimeter telescope (BLAST) has recently completed a highly successful long duration balloon flight from Antarctica. The instrument design incorporates a 2 m diameter primary mirror, with large format bolometer arrays operating at 250, 350 and 500 microns. By providing the first sensitive large-area (10 sq. degrees) surveys at these wavelengths, BLAST will address some of the most important galactic and cosmological questions regarding the formation and evolution of stars, galaxies and clusters

Submillimetre observations of galaxy clusters with the BLAST: the star formation activity in Abell 3112

We present observations at 250, 350 and 500 μm of the nearby galaxy cluster Abell 3112 (z= 0.075) carried out with the Balloon-borne Large Aperture Submillimeter Telescope. Five cluster members are individually detected as bright submillimetre (submm) sources. Their far-infrared spectral energy distributions and optical colours identify them as normal star-forming galaxies of high mass, with globally evolved stellar populations. They all have (B−R) colours of 1.38 ± 0.08, transitional between the blue, active population and the red, evolved galaxies that dominate the cluster core. We stack to estimate the mean submm emission from all cluster members, which is determined to be 16.6 ± 2.5, 6.1 ± 1.9 and 1.5 ± 1.3 mJy at 250, 350 and 500 μm, respectively. Stacking analyses of the submm emission of cluster members reveal trends in the mean far-infrared luminosity with respect to clustercentric radius and KS-band magnitude. We find that a large fraction of submm emission comes from the boundary of the inner, virialized region of the cluster, at clustercentric distances around R500. Stacking also shows that the bulk of the submm emission arises in intermediate-mass galaxies with KS magnitude ∼1 mag fainter than the characteristic magnitude . The results and constraints obtained in this work will provide a useful reference for the forthcoming surveys to be conducted on galaxy clusters by Herschel