293 research outputs found
Building SO(10) models from F-theory
We revisit local F-theory SO(10) and SU(5) GUTs and analyze their properties
within the framework of the maximal underlying E_8 symmetry in the elliptic
fibration. We consider the symmetry enhancements along the intersections of
seven-branes with the GUT surface and study in detail the embedding of the
abelian factors undergoing monodromies in the covering gauge groups. We combine
flux data from the successive breaking of SO(10) to SU(5) gauge symmetry and
subsequently to the Standard Model one, and further constrain the parameters
determining the models' particle spectra. In order to eliminate dangerous
baryon number violating operators we propose ways to construct matter parity
like symmetries from intrinsic geometric origin. We study implementations of
the resulting constrained scenario in specific examples obtained for a variety
of monodromies.Comment: 53 page
A Global SU(5) F-theory model with Wilson line breaking
We engineer compact SU(5) Grand Unified Theories in F-theory in which
GUT-breaking is achieved by a discrete Wilson line. Because the internal gauge
field is flat, these models avoid the high scale threshold corrections
associated with hypercharge flux. Along the way, we exemplify the
`local-to-global' approach in F-theory model building and demonstrate how the
Tate divisor formalism can be used to address several challenges of extending
local models to global ones. These include in particular the construction of
G-fluxes that extend non-inherited bundles and the engineering of U(1)
symmetries. We go beyond chirality computations and determine the precise
(charged) massless spectrum, finding exactly three families of quarks and
leptons but excessive doublet and/or triplet pairs in the Higgs sector
(depending on the example) and vector-like exotics descending from the adjoint
of SU(5)_{GUT}. Understanding why vector-like pairs persist in the Higgs sector
without an obvious symmetry to protect them may shed light on new solutions to
the mu problem in F-theory GUTs.Comment: 95 pages (71 pages + 1 Appendix); v2 references added, minor
correction
Froggatt-Nielsen models from E8 in F-theory GUTs
This paper studies F-theory SU(5) GUT models where the three generations of
the standard model come from three different curves. All the matter is taken to
come from curves intersecting at a point of enhanced E8 gauge symmetry. Giving
a vev to some of the GUT singlets naturally implements a Froggatt-Nielsen
approach to flavour structure. A scan is performed over all possible models and
the results are filtered using phenomenological constraints. We find a unique
model that fits observations of quark and lepton masses and mixing well. This
model suffers from two drawbacks: R-parity must be imposed by hand and there is
a doublet-triplet splitting problem.Comment: 42 pages; v2:journal version; v3:corrected typo in neutrino masse
Evidence of the physical interaction between rpl22 and the transposable element doc5, a heterochromatic transposon of drosophila melanogaster
Chromatin is a highly dynamic biological entity that allows for both the control of gene expression and the stabilization of chromosomal domains. Given the high degree of plasticity observed in model and non-model organisms, it is not surprising that new chromatin components are frequently described. In this work, we tested the hypothesis that the remnants of the Doc5 transpos-able element, which retains a heterochromatin insertion pattern in the melanogaster species complex, can be bound by chromatin proteins, and thus be involved in the organization of heterochromatic domains. Using the Yeast One Hybrid approach, we found Rpl22 as a potential interacting protein of Doc5. We further tested in vitro the observed interaction through Electrophoretic Mobility Shift Assay, uncovering that the N-terminal portion of the protein is sufficient to interact with Doc5. However, in situ localization of the native protein failed to detect Rpl22 association with chromatin. The results obtained are discussed in the light of the current knowledge on the extra-ribosomal role of ribosomal protein in eukaryotes, which suggests a possible role of Rpl22 in the determination of the heterochromatin in Drosophila
Versatile electrical stimulator for cardiac tissue engineering—Investigation of charge-balanced monophasic and biphasic electrical stimulations
The application of biomimetic physical stimuli replicating the in vivo dynamic microenvironment is crucial for the in vitro development of functional cardiac tissues. In particular, pulsed electrical stimulation (ES) has been shown to improve the functional properties of in vitro cultured cardiomyocytes. However, commercially available electrical stimulators are expensive and cumbersome devices while customized solutions often allow limited parameter tunability, constraining the investigation of different ES protocols. The goal of this study was to develop a versatile compact electrical stimulator (ELETTRA) for biomimetic cardiac tissue engineering approaches, designed for delivering controlled parallelizable ES at a competitive cost. ELETTRA is based on an open-source micro-controller running custom software and is combinable with different cell/tissue culture set-ups, allowing simultaneously testing different ES patterns on multiple samples. In particular, customized culture chambers were appositely designed and manufactured for investigating the influence of monophasic and biphasic pulsed ES on cardiac cell monolayers. Finite element analysis was performed for characterizing the spatial distributions of the electrical field and the current density within the culture chamber. Performance tests confirmed the accuracy, compliance, and reliability of the ES parameters delivered by ELETTRA. Biological tests were performed on neonatal rat cardiac cells, electrically stimulated for 4 days, by comparing, for the first time, the monophasic waveform (electric field = 5 V/cm) to biphasic waveforms by matching either the absolute value of the electric field variation (biphasic ES at ±2.5 V/cm) or the total delivered charge (biphasic ES at ±5 V/cm). Findings suggested that monophasic ES at 5 V/cm and, particularly, charge-balanced biphasic ES at ±5 V/cm were effective in enhancing electrical functionality of stimulated cardiac cells and in promoting synchronous contraction
Thermal Evolution of the Non Supersymmetric Metastable Vacua in N=2 SU(2) SYM Softly Broken to N=1
It has been shown that four dimensional N=2 gauge theories, softly broken to
N=1 by a superpotential term, can accommodate metastable non-supersymmetric
vacua in their moduli space. We study the SU(2) theory at high temperatures in
order to determine whether a cooling universe settles in the metastable vacuum
at zero temperature. We show that the corrections to the free energy because of
the BPS dyons are such that may destroy the existence of the metastable vacuum
at high temperatures. Nevertheless we demonstrate the universe can settle in
the metastable vacuum, provided that the following two conditions are hold:
first the superpotential term is not arbitrarily small in comparison to the
strong coupling scale of the gauge theory, and second the metastable vacuum
lies in the strongly coupled region of the moduli space.Comment: 32 pages, 30 figure
Tate Form and Weak Coupling Limits in F-theory
We consider the weak coupling limit of F-theory in the presence of
non-Abelian gauge groups implemented using the traditional ansatz coming from
Tate's algorithm. We classify the types of singularities that could appear in
the weak coupling limit and explain their resolution. In particular, the weak
coupling limit of SU(n) gauge groups leads to an orientifold theory which
suffers from conifold singulaties that do not admit a crepant resolution
compatible with the orientifold involution. We present a simple resolution to
this problem by introducing a new weak coupling regime that admits
singularities compatible with both a crepant resolution and an orientifold
symmetry. We also comment on possible applications of the new limit to model
building. We finally discuss other unexpected phenomena as for example the
existence of several non-equivalent directions to flow from strong to weak
coupling leading to different gauge groups.Comment: 34 page
An Instanton Toolbox for F-Theory Model Building
Several dimensionful parameters needed for model building can be engineered
in a certain class of SU(5) F-theory GUTs by adding extra singlet fields which
are localized along pairwise intersections of D7-branes. The values of these
parameters, however, depend on dynamics external to the GUT which causes the
singlets to acquire suitable masses or expectation values. In this note, we
demonstrate that D3-instantons which wrap the same 4-cycle as one of the
intersecting D7's can provide precisely the needed dynamics to generate several
important scales, including the supersymmetry-breaking scale and the
right-handed neutrino mass. Furthermore, these instantons seem unable to
directly generate the \mu term suggesting that, at least in this class of
models, it should perhaps be tied to one of the other scales in the problem.
More specifically, we study the simple system consisting of a pair of D7-branes
wrapping del Pezzo surfaces which intersect along a curve of genus 0
or 1 and classify all instanton configurations which can potentially contribute
to the superpotential. This allows one to formulate topological conditions
which must be imposed on \Sigma for various model-building applications. Along
the way, we also observe that the construction of arXiv:0808.1286 which
engineers a linear superpotential in fact realizes an O'Raifeartaigh model at
the KK scale whose 1-loop Coleman-Weinberg potential generically leads to a
metastable, long-lived SUSY-breaking vacuum.Comment: 18 pages, 2 figures; v2: updated to reflect corrections in v2 of
0808.128
Wavefunctions and the Point of E8 in F-theory
In F-theory GUTs interactions between fields are typically localised at
points of enhanced symmetry in the internal dimensions implying that the
coefficient of the associated operator can be studied using a local
wavefunctions overlap calculation. Some F-theory SU(5) GUT theories may exhibit
a maximum symmetry enhancement at a point to E8, and in this case all the
operators of the theory can be associated to the same point. We take initial
steps towards the study of operators in such theories. We calculate
wavefunctions and their overlaps around a general point of enhancement and
establish constraints on the local form of the fluxes. We then apply the
general results to a simple model at a point of E8 enhancement and calculate
some example operators such as Yukawa couplings and dimension-five couplings
that can lead to proton decay.Comment: 46 page
Silica nanoparticle internalization by human mesenchymal stem cells enhances their adhesion properties in dynamic conditions
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