7,060 research outputs found
Investigation of quantitative measures related to reading disability in a large sample of sib-pairs from the UK
We describe a family-based sample of individuals with reading disability collected as part of a quantitative trait loci (QTL) mapping study. Eighty-nine nuclear families (135 independent sib-pairs) were identified through a single proband using a traditional discrepancy score of predicted/actual reading ability and a known family history. Eight correlated psychometric measures were administered to each sibling, including single word reading, spelling, similarities, matrices, spoonerisms, nonword and irregular word reading, and a pseudohomophone test. Summary statistics for each measure showed a reduced mean for the probands compared to the co-sibs, which in turn was lower than that of the population. This partial co-sib regression back to the mean indicates that the measures are influenced by familial factors and therefore, may be suitable for a mapping study. The variance of each of the measures remained largely unaffected, which is reassuring for the application of a QTL approach. Multivariate genetic analysis carried out to explore the relationship between the measures identified a common factor between the reading measures that accounted for 54% of the variance. Finally the familiality estimates (range 0.32–0.73) obtained for the reading measures including the common factor (0.68) supported their heritability. These findings demonstrate the viability of this sample for QTL mapping, and will assist in the interpretation of any subsequent linkage findings in an ongoing genome scan
Enhanced Zeeman splitting in Ga0.25In0.75As quantum point contacts
The strength of the Zeeman splitting induced by an applied magnetic field is
an important factor for the realization of spin-resolved transport in
mesoscopic devices. We measure the Zeeman splitting for a quantum point contact
etched into a Ga0.25In0.75As quantum well, with the field oriented parallel to
the transport direction. We observe an enhancement of the Lande g-factor from
|g*|=3.8 +/- 0.2 for the third subband to |g*|=5.8 +/- 0.6 for the first
subband, six times larger than in GaAs. We report subband spacings in excess of
10 meV, which facilitates quantum transport at higher temperatures.Comment: [Version 2] Revtex4, 11 pages, 3 figures, accepted for publication in
Applied Physics Letter
Gravitational lensing statistics with extragalactic surveys. II. Analysis of the Jodrell Bank-VLA Astrometric Survey
We present constraints on the cosmological constant from
gravitational lensing statistics of the Jodrell Bank-VLA Astrometric Survey
(JVAS). Although this is the largest gravitational lens survey which has been
analysed, cosmological constraints are only comparable to those from optical
surveys. This is due to the fact that the median source redshifts of JVAS are
lower, which leads to both relatively fewer lenses in the survey and a weaker
dependence on the cosmological parameters. Although more approximations have to
be made than is the case for optical surveys, the consistency of the results
with those from optical gravitational lens surveys and other cosmological tests
indicate that this is not a major source of uncertainty in the results.
However, joint constraints from a combination of radio and optical data are
much tighter. Thus, a similar analysis of the much larger Cosmic Lens All-Sky
Survey should provide even tighter constraints on the cosmological constant,
especially when combined with data from optical lens surveys.
At 95% confidence, our lower and upper limits on ,
using the JVAS lensing statistics information alone, are respectively -2.69 and
0.68. For a flat universe, these correspond to lower and upper limits on
\lambda_{0} of respectively -0.85 and 0.84. Using the combination of JVAS
lensing statistics and lensing statistics from the literature as discussed in
Quast & Helbig (Paper I) the corresponding values are
-1.78 and 0.27. For a flat universe, these correspond to lower and upper limits
on of respectively -0.39 and 0.64.Comment: LaTeX, 9 pages, 18 PostScript files in 6 figures. Paper version
available on request. Data available from
http://gladia.astro.rug.nl:8000/ceres/data_from_papers/papers.htm
The association between knowledge of HPV and feelings of stigma, shame and anxiety
Objectives: To test the hypotheses that ( 1) women who know that human papillomavirus ( HPV) is sexually transmitted will expect to experience higher levels of stigma, shame and anxiety if they test positive for the virus than women who are not aware of the mode of transmission and ( 2) women who are aware of the high prevalence of HPV infection will expect to experience lower levels of stigma, shame and anxiety than women who underestimate its prevalence.Methods: A web-based survey in which information about HPV was manipulated to generate a 262 design ( awareness that HPV is sexually transmitted v no awareness; awareness of the high prevalence of HPV v no awareness). Participants ( n = 811) were female students. They were asked to imagine that they had tested positive for HPV. Outcome measures were expected stigma, shame and anxiety.Results: Great differences were observed in emotional reactions to imagining testing HPV positive between the four groups based on knowledge of HPV. Knowledge of the prevalence was associated with lower levels of stigma, shame and anxiety. Knowledge that HPV is sexually transmitted was associated with higher levels of stigma and shame, but not anxiety. Women who knew that HPV is sexually transmitted but not that it is highly prevalent had the highest scores for stigma and shame.Conclusions: Raising public awareness of the sexually transmitted nature of HPV has the potential to increase women's feelings of stigma and shame if they test positive for the virus. However, our findings suggest that ensuring women's awareness of HPV being common may reduce these feelings and also reduce anxiety, perhaps by "normalising'' the infection
Laser Guide Star for Large Segmented-Aperture Space Telescopes, Part I: Implications for Terrestrial Exoplanet Detection and Observatory Stability
Precision wavefront control on future segmented-aperture space telescopes
presents significant challenges, particularly in the context of high-contrast
exoplanet direct imaging. We present a new wavefront control architecture that
translates the ground-based artificial guide star concept to space with a laser
source aboard a second spacecraft, formation flying within the telescope
field-of-view. We describe the motivating problem of mirror segment motion and
develop wavefront sensing requirements as a function of guide star magnitude
and segment motion power spectrum. Several sample cases with different values
for transmitter power, pointing jitter, and wavelength are presented to
illustrate the advantages and challenges of having a non-stellar-magnitude
noise limited wavefront sensor for space telescopes. These notional designs
allow increased control authority, potentially relaxing spacecraft stability
requirements by two orders of magnitude, and increasing terrestrial exoplanet
discovery space by allowing high-contrast observations of stars of arbitrary
brightness.Comment: Submitted to A
Algorithmic Debugging of Real-World Haskell Programs: Deriving Dependencies from the Cost Centre Stack
Existing algorithmic debuggers for Haskell require a transformation of all modules in a program, even libraries that the user does not want to debug and which may use language features not supported by the debugger. This is a pity, because a promising ap- proach to debugging is therefore not applicable to many real-world programs. We use the cost centre stack from the Glasgow Haskell Compiler profiling environment together with runtime value observations as provided by the Haskell Object Observation Debugger (HOOD) to collect enough information for algorithmic debugging. Program annotations are in suspected modules only. With this technique algorithmic debugging is applicable to a much larger set of Haskell programs. This demonstrates that for functional languages in general a simple stack trace extension is useful to support tasks such as profiling and debugging
Lensing galaxies: light or dark?
In a recent paper, Hawkins (1997) argues on the basis of statistical studies
of double-image gravitational lenses and lens candidates that a large
population of dark lenses exists and that these outnumber galaxies with more
normal mass-to-light ratios by a factor of 3:1. If correct, this is a very
important result for many areas of astronomy including galaxy formation and
cosmology. In this paper we discuss our new radio-selected gravitational lens
sample, JVAS/CLASS, in order to test and constrain this proposition. We have
obtained ground-based and HST images of all multiple-image lens systems in our
sample and in 12 cases out of 12 we find the lensing galaxies in the optical
and/or near infrared. Our success in finding lensing galaxies creates problems
for the dark lens hypothesis. If it is to survive, ad hoc modifications seem to
be necessary: only very massive galaxies (more than about one trillion solar
masses) can be dark, and the cutoff in mass must be sharp. Our finding of lens
galaxies in all the JVAS/CLASS systems is complementary evidence which supports
the conclusion of Kochanek et al. (1997) that many of the wide-separation
optically-selected pairs are physically distinct quasars rather than
gravitational lens systems.Comment: 4 pages, 2 included figures, accepted for publication in Astronomy
and Astrophysics. Paper version available on request. This replacement amends
the text to allow more discussion of the overlap with astro-ph/971016
- …