Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been identified in humans and mice on the basis of their extensive portfolios of monoclonal antibodies (mAb) against Treg surface antigens. As an important veterinary species, dogs are increasingly recognised as an excellent model for many human diseases. However, insightful study of canine Tregs has been restrained by the limited availability of mAb. We therefore set out to characterise CD4+CD25high T cells isolated ex vivo from healthy dogs and showed that they possess a regulatory phenotype, function, and transcriptomic signature that resembles those of human and murine Tregs. By launching a cross-species comparison, we unveiled a conserved transcriptomic signature of Tregs and identified that transcript hip1 may have implications in Treg function

How to Discomfort a Worldview? Social Sciences, Surveillance Technologies and Defamiliarization

This chapter proposes two thinking exercises—or techniques—to nurture researchers’ ability to discomfort (their) worldviews: symmetric dispositifs and wildlife pictures. We believe that these thinking exercises can help us, and maybe other researchers, to achieve estrangement; i.e. to produce descriptions of our research objects that make them open to new, and possibly alternative, relations with them and among them. Our efforts are not to deny or debunk worldviews, but rather to provisionally break them apart, to destabilize them, to separate the worlds from the views, and then reunite them by emphasizing their constant and dynamic mutual construction. Practicing and embracing estrangement may help revive the desire to explore, test and fasten alternative world-view relationships, and—especially when security and surveillance technologies are at stake—it may highlight the (absurd) mechanisms of the power relations of everyday life

The poverty of Grand Theory

The editors of the special issue, in their call for papers for this special issue, expressed a degree of disquiet at the current state of International Relations theory, but the situation is both better and worse than they suggest. On the one hand, in some areas of the discipline, there has been real progress over the last decade. The producers of liberal and realist International Relations theory may not have the kind of standing in the social/human sciences as the 'Grand Theorists' identified by Quentin Skinner in his seminal mid-1980s' collection, but they have a great deal to say about how the world works, and the world would have been a better place over the last decade or so if more notice had been taken of what they did say. On the other hand, the range of late modern theorists who brought some of Skinner's Grand Theorists into the reckoning in the 1980s have, in the main, failed to deliver on the promises made in that decade. The state of International Relations theory in this neck of the woods is indeed a cause for concern; there is a pressing need for 'critical problem-solving' theory, that is, theory that relates directly to real-world problems but approaches them from the perspective of the underdog