A Class-AB/D Audio Power Amplifier for Mobile Applications Integrated Into a 2.5G/3G Baseband Processor

A filterless class-AB/D audio power amplifier integrated into a feature-rich 2.5G/3G baseband processor in standard 65-nm CMOS technology is designed for direct battery hookup in mobile phone applications. Circuit techniques are used to overcome the voltage limitations of standard MOS transistors for operation at voltage levels of 2.5-4.8 V. Both amplifiers can drive more than 650 mW into an 8-Omega load with maximum distortion levels of 1% and 5% for class-D and class-AB, respectively, all from a 3.6-V power supply. The achieved power-supply-rejection ratios are 72 and 84 dB, respectively. The mono implementation of both amplifiers together is 0.44 mm(2)

Cyclic changes of sensory parameters in migraine patients

Background Migraine shows a cyclic pattern with an inter-ictal-, a pre-ictal, an ictal- and a post-ictal phase. We aimed to examine changes in psychophysical parameters during the migraine cycle. Methods The perception of nociceptive and non-nociceptive stimuli and an electrically induced axon-reflex-erythema were assessed in 20 healthy controls and 14 migraine patients on five consecutive days according to different phases of the migraine cycle. Pain was rated three times during a 10-second electrical stimulus. The size of the axon-reflex-erythema was determined using laser-Doppler-imaging. Intensity and hedonic estimates of odours presented by Sniffin’ Sticks were rated. Results In healthy controls, no significant changes over the test days were observed. In migraine patients pain thresholds at the head decreased with an ictal minimum. Less habituation after five seconds of stimulation at the head was found pre-ictally, whereas reduced habituation to 10-second electrical stimulation was present in all phases. The axon-reflex-erythema size showed an inter-ictal-specific minimum at the head. odours were perceived ictally as more unpleasant and intense. Conclusions Somatosensory functions, pain thresholds and habituation as predominantly central parameters, axon-reflex-erythema as a peripheral function of trigeminal neurons and odour perception as a predominantly extra-thalamic sensation change specifically over the migraine cycle indicating complex variations of neuronal signal processing