11,025 research outputs found
An observational test of common-envelope evolution
By analysing and modelling the change in the abundance ratio of
C/C and O/O on the surface of the lower mass star
of a binary during the common-envelope (CE) phase of evolution, we propose a
simple observational test of the CE scenario. The test is based on the infrared
measurement of either the C/C or O/O ratio of red
dwarfs in post-common envelope binaries (PCEB's). In certain cases
(main-sequence red dwarf secondaries in PCEB's without planetary nebulae), as
well as determining whether or not accretion has occurred during the CE phase,
we can determine the amount of mass accreted during the CE phase and hence the
initial mass of the red dwarf component prior to the CE phase. In the other
cases considered (low-mass red dwarfs in PCEB's and red dwarf's in PCEB's with
planetary nebulae) we can only say whether or not accretion has occurred during
the CE phase.Comment: uuencoded compressed postscript. The preprint are also available at
URL http://www.ast.cam.ac.uk/preprint/PrePrint.htm
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Primary Murine CD4<sup>+</sup> T Cells Fail to Acquire the Ability to Produce Effector Cytokines When Active Ras Is Present during Th1/Th2 Differentiation
Constitutive Ras signaling has been shown to augment IL-2 production, reverse anergy, and functionally replace many aspects of CD28 co-stimulation in CD4+ T cells. These data raise the possibility that introduction of active Ras into primary T cells might result in improved functionality in pathologic situations of T cell dysfunction, such as cancer or chronic viral infection. To test the biologic effects of active Ras in primary T cells, CD4+ T cells from Coxsackie-Adenovirus Receptor Transgenic mice were transduced with an adenovirus encoding active Ras. As expected, active Ras augmented IL-2 production in naive CD4+ T cells. However, when cells were cultured for 4 days under conditions to promote effector cell differentiation, active Ras inhibited the ability of CD4+ T cells to acquire a Th1 or Th2 effector cytokine profile. This differentiation defect was not due to deficient STAT4 or STAT6 activation by IL-12 or IL-4, respectively, nor was it associated with deficient induction of T-bet and GATA-3 expression. Impaired effector cytokine production in active Ras-transduced cells was associated with deficient demethylation of the IL-4 gene locus. Our results indicate that, despite augmenting acute activation of naĂŻve T cells, constitutive Ras signaling inhibits the ability of CD4+ T cells to properly differentiate into Th1/Th2 effector cytokine-producing cells, in part by interfering with epigenetic modification of effector gene loci. Alternative strategies to potentiate Ras pathway signaling in T cells in a more regulated fashion should be considered as a therapeutic approach to improve immune responses in vivo.</p
Nulling interferometry: performance comparison between Antarctica and other ground-based sites
Detecting the presence of circumstellar dust around nearby solar-type main
sequence stars is an important pre-requisite for the design of future
life-finding space missions such as ESA's Darwin or NASA's Terrestrial Planet
Finder (TPF). The high Antarctic plateau may provide appropriate conditions to
perform such a survey from the ground. We investigate the performance of a
nulling interferometer optimised for the detection of exozodiacal discs at Dome
C, on the high Antarctic plateau, and compare it to the expected performance of
similar instruments at temperate sites. Based on the currently available
measurements of the turbulence characteristics at Dome C, we adapt the GENIEsim
software (Absil et al. 2006, A&A 448) to simulate the performance of a nulling
interferometer on the high Antarctic plateau. To feed a realistic instrumental
configuration into the simulator, we propose a conceptual design for ALADDIN,
the Antarctic L-band Astrophysics Discovery Demonstrator for Interferometric
Nulling. We assume that this instrument can be placed above the 30-m high
boundary layer, where most of the atmospheric turbulence originates. We show
that an optimised nulling interferometer operating on a pair of 1-m class
telescopes located 30 m above the ground could achieve a better sensitivity
than a similar instrument working with two 8-m class telescopes at a temperate
site such as Cerro Paranal. The detection of circumstellar discs about 20 times
as dense as our local zodiacal cloud seems within reach for typical Darwin/TPF
targets in a integration time of a few hours. Moreover, the exceptional
turbulence conditions significantly relax the requirements on real-time control
loops, which has favourable consequences on the feasibility of the nulling
instrument.Comment: 10 pages, accepted for publication in A&
RHEBI Expression in Embryonic and Postnatal Mouse
Ras homolog enriched in brain (RHEB1) is a member within the superfamily of GTP-binding proteins encoded by the RAS oncogenes. RHEB1 is located at the crossroad of several important pathways including the insulin-signaling pathways and thus plays an important role in different physiological processes. To understand better the physiological relevance of RHEB1 protein, the expres- sion pattern of RHEB1 was analyzed in both embryonic (at E3.5–E16.5) and adult (1-month old) mice. RHEB1 immu- nostaining and X-gal staining were used for wild-type and Rheb1 gene trap mutant mice, respectively. These inde- pendent methods revealed similar RHEB1 expression pat- terns during both embryonic and postnatal developments. Ubiquitous uniform RHEB1/β-gal and/or RHEB1 expres- sion was seen in preimplantation embryos at E3.5 and post- implantation embryos up to E12.5. Between stages E13.5 and E16.5, RHEB1 expression levels became complex: In particular, strong expression was identified in neural tis- sues, including the neuroepithelial layer of the mesenceph- alon, telencephalon, and neural tube of CNS and dorsal root ganglia. In addition, strong expression was seen in certain peripheral tissues including heart, intestine, muscle, and urinary bladder. Postnatal mice have broad spatial RHEB1 expression in different regions of the cerebral cortex, sub- cortical regions (including hippocampus), olfactory bulb, medulla oblongata, and cerebellum (particularly in Purkinje cells). Significant RHEB1 expression was also viewed in internal organs including the heart, intestine, urinary blad- der, and muscle. Moreover, adult animals have complex tis- sue- and organ-specific RHEB1 expression patterns with different intensities observed throughout postnatal develop- ment. Its expression level is in general comparable in CNS and other organs of mouse. Thus, the expression pattern of RHEB1 suggests that it likely plays a ubiquitous role in the development of the early embryo with more tissue-specific roles in later development
Using binary statistics in Taurus-Auriga to distinguish between brown dwarf formation processes
Whether BDs form as stars through gravitational collapse ("star-like") or BDs
and some very low-mass stars constitute a separate population which form
alongside stars comparable to the population of planets, e.g. through
circumstellar disk ("peripheral") fragmentation, is one of the key questions of
the star-formation problem. For young stars in Taurus-Auriga the binary
fraction is large with little dependence on primary mass above ~0.2Msun, while
for BDs it is <10%. We investigate a case in which BDs in Taurus formed
dominantly through peripheral fragmentation. The decline of the binary
frequency in the transition region between star-like and peripheral formation
is modelled. A dynamical population synthesis model is employed in which
stellar binary formation is universal. Peripheral objects form separately in
circumstellar disks with a distinctive initial mass function (IMF), own orbital
parameter distributions for binaries and a low binary fraction. A small amount
of dynamical processing of the stellar component is accounted for as
appropriate for the low-density Taurus-Auriga embedded clusters. The binary
fraction declines strongly between the mass-limits for star-like and peripheral
formation. The location of characteristic features and the steepness depend on
these mass-limits. Such a trend might be unique to low density regions hosting
dynamically unprocessed binary populations. The existence of a strong decline
in the binary fraction -- primary mass diagram will become verifiable in future
surveys on BD and VLMS binarity in the Taurus-Auriga star forming region. It is
a test of the (non-)continuity of star formation along the mass-scale, the
separateness of the stellar and BD populations and the dominant formation
channel for BDs and BD binaries in regions of low stellar density hosting
dynamically unprocessed populations.Comment: accepted for publication in A&A, 11 pages, 4 figures, 1 tabl
An anomalous alloy: Y_x Si_{1-x}
We study via density functional-based molecular dynamics the structural and
dynamical properties of the rare earth silicon amorphous alloy Y_xSi_{1-x} for
x=0.093 and x=0.156. The Si network forms cavities in which a Y^{3+} cation is
entrapped. Its electrons are transferred to the Si network and are located in
the dangling bonds of the Si atoms that line the Y cavities. This leads to the
presence of low coordinated Si atoms that can be described as monovalent or
divalent anions. For x=0.156, the cavities touch each other and share Si atoms
that have two dangling bonds. The vibrational spectrum is similar to that of
amorphous Si. However, doping induces a shoulder at 70 cm^{-1} and a pronounced
peak at 180 cm^{-1} due to low coordinated Si.Comment: 4 pages, 4 figure
RHEB1 Expression in Embryonic and Postnatal Mouse
Ras homolog enriched in brain (RHEB1) is a member within the superfamily of GTP-binding proteins encoded by the RAS oncogenes. RHEB1 is located at the crossroad of several important pathways including the insulin-signaling pathways and thus plays an important role in different physiological processes. To understand better the physiological relevance of RHEB1 protein, the expres-sion pattern of RHEB1 was analyzed in both embryonic (at E3.5–E16.5) and adult (1-month old) mice. RHEB1 immu-nostaining and X-gal staining were used for wild-type and Rheb1 gene trap mutant mice, respectively. These inde-pendent methods revealed similar RHEB1 expression pat-terns during both embryonic and postnatal developments. Ubiquitous uniform RHEB1/β-gal and/or RHEB1 expres-sion was seen in preimplantation embryos at E3.5 and post-implantation embryos up to E12.5. Between stages E13.5 and E16.5, RHEB1 expression levels became complex: In particular, strong expression was identified in neural tis-sues, including the neuroepithelial layer of the mesenceph-alon, telencephalon, and neural tube of CNS and dorsal root ganglia. In addition, strong expression was seen in certain peripheral tissues including heart, intestine, muscle, and urinary bladder. Postnatal mice have broad spatial RHEB1 expression in different regions of the cerebral cortex, sub-cortical regions (including hippocampus), olfactory bulb, medulla oblongata, and cerebellum (particularly in Purkinje cells). Significant RHEB1 expression was also viewed in internal organs including the heart, intestine, urinary blad-der, and muscle. Moreover, adult animals have complex tis-sue- and organ-specific RHEB1 expression patterns with different intensities observed throughout postnatal develop-ment. Its expression level is in general comparable in CNS and other organs of mouse. Thus, the expression pattern of RHEB1 suggests that it likely plays a ubiquitous role in the development of the early embryo with more tissue-specific roles in later development
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