YF-12 cooperative airframe/propulsion control system program, volume 1

Several YF-12C airplane analog control systems were converted to a digital system. Included were the air data computer, autopilot, inlet control system, and autothrottle systems. This conversion was performed to allow assessment of digital technology applications to supersonic cruise aircraft. The digital system was composed of a digital computer and specialized interface unit. A large scale mathematical simulation of the airplane was used for integration testing and software checkout

Geobase Information System Impacts on Space Image Formats

As Geobase Information Systems increase in number, size and complexity, the format compatability of satellite remote sensing data becomes increasingly more important. Because of the vast and continually increasing quantity of data available from remote sensing systems the utility of these data is increasingly dependent on the degree to which their formats facilitate, or hinder, their incorporation into Geobase Information Systems. To merge satellite data into a geobase system requires that they both have a compatible geographic referencing system. Greater acceptance of satellite data by the user community will be facilitated if the data are in a form which most readily corresponds to existing geobase data structures. The conference addressed a number of specific topics and made recommendations

Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior

Prenatal nicotine exposure has been linked to attention deficit hyperactivity disorder and cognitive impairment, but the sites of action for these effects of nicotine are still under investigation. High-affinity nicotinic acetylcholine receptors (nAChRs) contain the .2 subunit and modulate passive avoidance (PA) learning in mice. Using an inducible, tetracycline-regulated transgenic system, we generated lines of mice with expression of high-affinity nicotinic receptors restored in specific neuronal populations. One line of mice shows functional .2 subunit-containing nAChRs localized exclusively in corticothalamic efferents. Functional, presynaptic nAChRs are present in the thalamus of these mice as detected by nicotine-elicited rubidium efflux assays from synaptosomes. Knock-out mice lacking high-affinity nAChRs show elevated baseline PA learning, whereas normal baseline PA behavior is restored in mice with corticothalamic expression of these nAChRs. In contrast, nicotine can enhance PA learning in adult wild-type animals but not in corticothalamic-expressing transgenic mice. When these transgenic mice are treated with doxycycline in adulthood to switch off nAChR expression, baseline PA is maintained even after transgene expression is abolished. These data suggest that high-affinity nAChRs expressed on corticothalamic neurons during development are critical for baseline PA performance and provide a potential neuroanatomical substrate for changes induced by prenatal nicotine exposure leading to long-term behavioral and cognitive deficits

Recent advances on IMF research

Here I discuss recent work on brown dwarfs, massive stars and the IMF in general. The stellar IMF can be well described by an invariant two-part power law in present-day star-formation events within the Local Group of galaxies. It is nearly identical in shape to the pre-stellar core mass function. The majority of brown dwarfs follow a separate IMF. Evidence from globular clusters and ultra-compact dwarf galaxies has emerged that IMFs may have been top heavy depending on the star-formation rate density. The IGIMF then ranges from bottom heavy at low galaxy-wide star formation rates to being top-heavy in galaxy-scale star bursts.Comment: 6 pages, LaTeX, to appear in The Labyrinth of Star Formation, 18-22 June 2012, Crete, (eds.) D. Stamatellos, S. Goodwin, and D. Ward-Thompson, Springer, in press; replaced version: very minor corrections plus the addition of reference Smith & Lucey (2013) on the bottom-heavy IMF in elliptical galaxie

Effects of progesterone on mammary carcinogenesis by DMBA applied directly to rat mammae.

The effects and site(s) of action of progesterone on DMBA mammary carcinogenesis in the rat, when a small dose of the carcinogen was applied directly to the inguinal mammary gland, were investigated. No reduction in tumour yield was apparent when progesterone was administered s.c. for 18 days before dusting DMBA. This finding contrasts with a previously reported inhibitory effect on carcinogenesis when hormone treatment was followed by intragastric administration of DMBA. When progesterone injections were begun either 2 days before or 2 days after direct application of DMBA, and were continued until the end of the experiment (135 or 195 days) an enhancement in carcinogenesis was observed similar to that previously demonstrated after gastric intubation of DMBA. These findings, together with previously reported observations, suggest that progesterone may exert its inhibitory effect on carcinogenesis by acting at a site outside the breast, perhaps on the liver. However, it is likely that the hormone acts directly on the mammary tissue to exert its enhancing effect on tumorigenesis

Applications of M.G. Krein's Theory of Regular Symmetric Operators to Sampling Theory

The classical Kramer sampling theorem establishes general conditions that allow the reconstruction of functions by mean of orthogonal sampling formulae. One major task in sampling theory is to find concrete, non trivial realizations of this theorem. In this paper we provide a new approach to this subject on the basis of the M. G. Krein's theory of representation of simple regular symmetric operators having deficiency indices (1,1). We show that the resulting sampling formulae have the form of Lagrange interpolation series. We also characterize the space of functions reconstructible by our sampling formulae. Our construction allows a rigorous treatment of certain ideas proposed recently in quantum gravity.Comment: 15 pages; v2: minor changes in abstract, addition of PACS numbers, changes in some keywords, some few changes in the introduction, correction of the proof of the last theorem, and addition of some comments at the end of the fourth sectio