16 research outputs found
Synthesis and self-assembly of lipid (DMPC)-conjugated gold nanoparticles
Bio-conjugated nanomaterials play a promising role in the development of
novel supramolecular structures, molecular machines, and biosensing devices. In
this study, lipid-conjugated gold nanoparticles were synthesized and allowed to
form a self-assembled monolayer structure. The nanoparticles were prepared by a
phase transfer method, which involved the reduction of potassium
tetrachloroaurate (III) by sodium citrate in an aqueous solution and the
simultaneous transfer of the reduced species to an organic medium containing
DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine). The gold nanoparticles were
characterized using UV-Vis spectroscopy and dynamic light scattering (DLS)
particle-size analysis. In addition, the resulting nanoparticles were examined
using transmission electron microscopy (TEM). The Langmuir-Blodgett (LB)
technique was used to assemble the DMPC-capped nanoparticles onto a water
subphase at room temperature. The measurement of the compression isotherm
confirmed the assemblage of lipid capped gold nanoparticles. This method of
synthesis of ordered structures utilizing molecular interactions of lipids will
be useful in developing novel metamaterials and nanocircuits.Comment: 7 pages, 5 Figure
Probing the two-dimensional assembly of inorganic complexes and heterocycles for sensing applications
Thesis: Ph. D. in Inorganic Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2017.Cataloged from PDF version of thesis.Includes bibliographical references.Chemiresistive sensing is a facile, affordable, efficient, and translatable way to detect compounds at concentrations as low as parts per billion; however, the key mechanism of molecular sensing is still unknown. In this thesis, a fundamental approach is used to study molecular assembly and reactivity by looking at the intermolecular interactions of each system presented to determine how specific interactions impact the macroscopic properties or ability of the chemical species to detect incoming analyte gases relevant for chemical sensing. Scanning Tunneling Microscopy (STM) was used as a primary tool to better understand the changes to a sensing system at the molecular level. In a similar vein, several platinum complexes useful as luminescence-based chemical sensors were studied using various liquid crystalline characterization techniques to understand how their intermolecular properties impacted their bulk assembly behavior. The Swager lab has developed chemiresistive and luminescence-based sensors for a wide variety of applications and it is the hope that fundamental studies such as this will help elucidate the molecular basis of the sensing response and in the long term will allow for the development of more sophisticated and predictable sensors.by Markrete Krikorian.Ph. D. in Inorganic Chemistr
Columnar Liquid Crystallinity and Mechanochromism in Cationic Platinum(II) Complexes
Cationic square planar Pt(II) complexes are reported with high degrees of intermolecular association. These complexes display thermotropic columnar liquid crystalline behavior in spite of having only a single side chain. Crystals undergo mechanochromic transformations that can be reversed with solvent.National Science Foundation (U.S.) (Award DMR-1005810)American Society for Engineering Education (Award 2291100
Columnar Liquid Crystallinity and Mechanochromism in Cationic Platinum(II) Complexes
Cationic square planar PtĀ(II) complexes
are reported with high
degrees of intermolecular association. These complexes display thermotropic
columnar liquid crystalline behavior in spite of having only a single
side chain. Crystals undergo mechanochromic transformations that can
be reversed with solvent
Ultratrace Detection of Toxic Chemicals: Triggered Disassembly of Supramolecular Nanotube Wrappers
Chemical sensors
offer opportunities for improving personal security,
safety, and health. To enable broad adoption of chemical sensors requires
performance and cost advantages that are best realized from innovations
in the design of the sensing (transduction) materials. Ideal materials
are sensitive and selective to specific chemicals or chemical classes
and provide a signal that is readily interfaced with portable electronic
devices. Herein we report that wrapping single walled carbon nanotubes
with metallo-supramolecular polymers creates sensory devices with
a dosimetric (time- and concentration-integrated) increase in electrical
conductivity that is triggered by electrophilic chemical substances
such as diethylchlorophosphate, a nerve agent simulant. The mechanism
of this process involves the disassembly of the supramolecular polymer,
and we demonstrate its utility in a wireless inductively powered sensing
system based on near-field communication technology. Specifically,
the dosimeters can be powered and read wirelessly with conventional
smartphones to create sensors with ultratrace detection limits
STM Study of Gold(I) Pyrazolates: Distinct Morphologies, Layer Evolution, and Cooperative Dynamics
We describe the first study of trinuclear
goldĀ(I) pyrazolates on
the molecular level by time-dependent scanning tunneling microscopy
(STM). On the graphite/1-octanoic acid interface dodecyl-functionalized
gold pyrazolates formed concentration-controlled morphologies. We
found two types of monomeric packing and one dimeric type with two
trinuclear gold pyrazolates next to each other on the surface. For
an octadecyl-functionalized derivative all studied concentrations
resulted in a dimeric morphology. However, different concentrations
led to different transient states during the layer evolution. At low
concentrations, a transient monomeric state was present with the alkyl
chains in a gauche-conformation that subsequently converted to a more
optimized anti-conformation. At higher concentrations a less stable
ālineā polymorph was observed. The confinement of the
molecules to the surface led to cooperative dynamics, in which two
molecules in a dimer moved as if they were one particle. Furthermore,
in a higher level of cooperativity, the rotation of one dimer appears
to induce rotations in coupled neighboring dimers
Functionalizing molecular wires: a tunable class of a,u-diphenyl-m, n-dicyano-oligoenes ā ā”
We describe the synthesis and characterization of a new class of cyano-functionalized oligoenes and their derivatives. We have made the vinylogous series of a,u-diphenyl-m,n-dicyano-oligoenes (DPDCn) comprised of each odd-numbered member from 3 to 13 linear conjugated olefins. Installing cyano groups onto the oligoene backbone lowers HOMO and LUMO energies by up to $0.7 eV, thereby stabilizing the molecule with respect to oxidative decomposition; this exemplifies a new approach to the stabilization of conjugated oligoenes. UV-vis absorption spectra and redox potentials across the DPDCn series reveal that the molecular band gap ranges from 2.80 to 1.75 eV. This gap can be further tuned by the facile installation of a variety of aryl end-groups. The choice of end-groups also greatly affects the physical properties such as solubility and the solid-state packing. We also present the longest oligoene crystal structure reported to date. Moreover, we find that the prototypical linear structure makes oligoenes suitable as molecular wires and connectors in the bottom-up construction of nanoscale architectures. As a proof of concept, carboxylic acid terminated oligoenes were used to position 10-nm Fe 3 O 4 nanoparticles on a GaAs (100) substrate
Smectic A mesophases from luminescent sandic platinum(II) mesogens
Square planar platinum(II) thienyl pyridyl complexes with board-shaped structures assemble into lamellar (SmA) liquid crystal phases at elevated temperatures. Liquid crystals of this type are expected to have stronger biaxial correlations than typical calamitic mesogens. The mesophase stability improves with decreasing alkyl chain lengths with CāHāā having the widest range of stability. All complexes are luminescent in solution.National Science Foundation (U.S.) (Grant DMR-1410718
Importance of Direct MetalāĻ Coupling in Electronic Transport Through Conjugated Single-Molecule Junctions
We study the effects of molecular structure on the electronic
transport
and mechanical stability of single-molecule junctions formed with
Au point contacts. Two types of linear conjugated molecular wires
are compared: those functionalized with methylsulfide or amine aurophilic
groups at (1) both or (2) only one of its phenyl termini. Using scanning
tunneling and atomic force microscope break-junction techniques, the
conductance of mono- and difunctionalized molecular wires and its
dependence on junction elongation and rupture forces were studied.
Charge transport through monofunctionalized wires is observed when
the molecular bridge is coupled through a SāAu donorāacceptor
bond on one end and a relatively weak AuāĻ interaction
on the other end. For monofunctionalized molecular wires, junctions
can be mechanically stabilized by installing a second aurophilic group
at the <i>meta</i> position that, however, does not in itself
contribute to a new conduction pathway. These results reveal the important
interplay between electronic coupling through metalāĻ
interactions and quantum mechanical effects introduced by chemical
substitution on the conjugated system. This study affords a strategy
to deterministically tune the electrical and mechanical properties
through molecular wires