39,011 research outputs found

    Developing a Conceptual Framework for Cloud Security Assurance

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    Measurement of substrate thermal resistance using DNA denaturation temperature

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    Heat Transfer and Thermal Management have become important aspects of the developing field of uTAS systems particularly in the application of the the uTAS philosophy to thermally driven analysis techniques such as PCR. Due to the development of flowing PCR thermocyclers in the field of uTAS, the authors have previously developed a melting curve analysis technique that is compatible with these flowing PCR thermocyclers. In this approach a linear temperature gradient is induced along a sample carrying microchannel. Any flow passing through the microchannel is subject to linear heating. Fluorescent monitoring of DNA in the flow results in the generation of DNA melting curve plots. This works presents an experimental technique where DNA melting curve analysis is used to measure the thermal resistance of microchannel substrates. DNA in solution is tested at a number of different ramp rates and the di®erent apparent denaturation temperatures measured are used to infer the thermal resistance of the microchannel substrates. The apparent variation in denaturation temperature is found to be linearly proportional to flow ramp rate. Providing knowledge of the microchannel diameter and a non-varying cross-section in the direction of heat flux the thermal resistance measurement technique is independent of knowledge of substrate dimensions, contact surface quality and substrate composition/material properties. In this approach to microchannel DNA melting curve analysis the difference between the measured and actual denaturation temperatures is proportional to the substrate thermal resistance and the ramp-rate seen by the sample. Therefore quantitative knowledge of the substrate thermal resistance is required when using this technique to measure accurately DNA denaturation temperatur

    Structural trends in clusters of quadrupolar spheres

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    The influence of quadrupolar interactions on the structure of small clusters is investigated by adding a point quadrupole of variable strength to the Lennard-Jones potential. Competition arises between sheet-like arrangements of the particles, favoured by the quadrupoles, and compact structures, favoured by the isotropic Lennard-Jones attraction. Putative global potential energy minima are obtained for clusters of up to 25 particles using the basin-hopping algorithm. A number of structural motifs and growth sequences emerge, including star-like structures, tubes, shells and sheets. The results are discussed in the context of colloidal self-assembly.Comment: 8 pages, 6 figure

    Secondary resurfacing of the patella in total knee arthroplasty

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    Anterior knee pain following primary total knee arthroplasty is common and can be difficult to treat satisfactorily. We reviewed 28 consecutive patients (29 knees) who underwent secondary resurfacing of the patella for persistent anterior knee pain and report on the results. Mean follow-up was 28 months (range12-61) with no cases lost to follow-up. Oxford knee scores, range of motion, the patient's assessment of outcome and overall satisfaction were recorded. Seventeen out of 19 (59%) felt their knee was better following patellar resurfacing, 10 out of 29 (34%) felt it was the same and two out of 29 (7%) felt it was worse. There was a significant improvement in Oxford knee scores (p < 0.001) and significant increase in patient satisfaction (p < 0.001) following secondary resurfacing. While secondary resurfacing of the patella does not provide the solution for every case of anterior knee pain following total knee joint replacement, in greater than 50% of cases it can be effective at relieving symptoms and in this series carries a low risk of worsening symptoms or complications

    Advanced 3-D viscous SSME turbine rotor stator CFD algorithms

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    Current Space Shuttle Main Engine (SSME) high pressure fuel turbopump problems have generated a desire to analyze the flow field of rotating machinery. The status of Computational Fluid Dynamics (CFD) has reached the point that soon the capability to solve unsteady three-dimensional viscous flow fields will be at hand. The work presented involves upgrading the computational efficiency of an operational three-dimensional algorithm. The modifications include algorithm development, algorithm approximation and acceleration, and special coding optimizations. The overall result of these modifications has reduced processing time by nearly 80%

    A Two-Dimensional Carbon Semiconductor

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    We show that patterned defects can be used to disrupt the sub-lattice symmetry of graphene so as to open up a band gap. This way of modifying graphene's electronic structure does not rely on external agencies, the addition of new elements or special boundaries. The method is used to predict a planar, low energy, graphene allotrope with a band gap of 1.2 eV. This defect engineering also allows semiconducting ribbons of carbon to be fabricated within graphene. Linear arrangements of defects lead to naturally embedded ribbons of the semiconducting material in graphene, offering the prospect of two-dimensional circuit logic composed entirely of carbon.Comment: 4 pages, 5 figure

    Origin of the Near-Ecliptic Circumsolar Dust Band

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    The zodiacal dust bands are bright infrared (IR) strips produced by thermal emission from circumsolar rings of particles. Two of the three principal dust bands, known as β and γ, were previously linked to the recent asteroid collisions that produced groups of fragments, so-called asteroid families, near the orbits of (832) Karin and (490) Veritas. The origin of the third, near-ecliptic α band has been unknown until now. Here we report the discovery of a recent breakup of a >20 km diameter asteroid near α's originally suspected source location in the Themis family. Numerical modeling and observations of the α-band thermal emission from the Spitzer Space Telescope indicate that the discovered breakup is the source of α-band particles. The recent formation of all principal dust bands implies a significant time variability of the circumstellar debris disks

    Dark retweets: investigating non-conventional retweeting patterns

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    Retweets are an important mechanism for recognising propagation of information on the Twitter social media platform. However, many retweets do not use the official retweet mechanism, or even community established conventions, and these "dark retweets" are not accounted for in many existing analysis. In this paper, a comprehensive matrix of tweet propagation is presented to show the different nuances of retweeting, based on seven characteristics: whether it is proprietary, the mechanism used, whether it is directed to followers or non-followers, whether it mentions other users, if it is explicitly propagating another tweet, if it links to an original tweet, and what is the audience it is pushed to. Based on this matrix and two assumptions of retweetability, the degrees of a retweet's "darkness" can be determined. This matrix was evaluated over 2.3 million tweets and it was found that dark retweets amounted to 12.86% (for search results less than 1500 tweets per URL) and 24.7% (for search results including more than 1500 tweets per URL) respectively. By extrapolating these results with those found in existing studies, potentially thousands of retweets may be hidden from existing studies on retweets
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