7 research outputs found
HTRA3 expression in non-pregnant rhesus monkey ovary and endometrium, and at the maternal-fetal interface during early pregnancy
Genetic diversity fuels gene discovery for tobacco and alcohol use
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury(1-4). These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries(5). Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.Peer reviewe
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Prescription Privileges for Psychologists: Opinions of Pediatric Psychologists and Pediatricians
Objective To examine the opinions of pediatricians and pediatric psychologists concerning prescription privileges for psychologists. Methods 213 pediatric psychologists and 119 pediatricians returned surveys regarding their opinions about cost, access, and quality of psychological care if psychologists had prescription privileges. Results Pediatric psychologists had significantly more positive views of prescription privileges than pediatricians. Despite not being in favor of prescription privileges, most pediatricians said that prescription privileges would not negatively impact their professional relationship, although ∼37% said it would. Conclusion Pediatric psychologists and pediatricians differ significantly in their opinions about prescription privileges for psychologists. The implications of these findings for the working relationship between these two disciplines are discussed
Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function
The effect of nitrogen addition on soil organic matter dynamics: a model analysis of the Harvard Forest Chronic Nitrogen Amendment Study and soil carbon response to anthropogenic N deposition
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Genetic diversity fuels gene discovery for tobacco and alcohol use
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1-4. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries5. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction