29 research outputs found

    Merkel cell carcinoma of the skin. Treatment of primary, recurrent and metastatic disease: review of clinical cases.

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    The clinical features of 10 cases of primary neuroendocrine carcinoma of the skin (Merker cell tumor) are reported. This cancer arises in the dermis and subcutaneous tissues of elderly individuals. Natural history is characterized by local recurrences (30\%), regional lymph node metastases (65\%) and distant metastases (40\%). Surgery is elective treatment, chemotherapy and radiotherapy resulted only to short-term palliative response

    Relevance of HBV/HBcAb screening in lymphoma patients treated in the Rituximab era

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    The addition of Rituximab (anti-CD20 monoclonal antibody) to chemotherapy has dramatically increased survival of non-Hodgkin\u2019s lymphoma (NHL) patients. However, in view of the intrinsic immunosuppressive effect of this drug, new questions are emerging in clinical practice. Among these, the assessment and proper interpretation of HBV serological status in patients undergoing Rituximab-based chemotherapy are of special concern. This topic was the object of a recently interesting review published on your journa. However, in the last few months, two other studies were published, which investigated the incidence of HBV in NHL patients treated with Rituximab-based regimens
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