Characterization of A phases during the Cyclic Alternating Pattern of sleep

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Efficient automatic classifiers for the detection of A phases of the cyclic alternating pattern in sleep

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Extracción de li desde alfa-espodumeno mediante activación mecánica y lixiviación a baja temperatura

En este trabajo se estudió la extracción de litio desde α-espodumeno mediante activación mecánica con NaF y lixiviación con solución de NaF/H2SO4 a bajas temperaturas (≤90ºC). Los parámetros operativos investigados fueron: tiempo de activación mecánica, temperatura de reacción y tiempo de lixiviación. El efecto de los parámetros del proceso en la eficiencia de la extracción de litio fue estudiado mediante metodología de superficie de respuesta basada en un diseño D-optimal. Los resultados indicaron que el tiempo de molienda, la temperatura y el tiempo de lixiviación tuvieron un efecto positivo en la extracción de litio. La temperatura, el tiempo de lixiviación y su interacción tuvieron un mayor efecto en la extracción de litio. El valor óptimo de extracción de Li alcanzado fue del 81% trabajando con una muestra activada 600 min, y una temperatura y tiempo de lixiviación de 90°C y 240 min, respectivamente.Fil: Rosales, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; ArgentinaFil: Matteucci, Natasha. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; ArgentinaFil: Resentera, Alexander. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; ArgentinaFil: Wuilloud, Carlos Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; ArgentinaFil: Rodriguez, Mario Humberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; ArgentinaFil: Esquivel, Marcelo Ricardo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; ArgentinaXV Jornadas Argentinas de Tratamiento de MineralesSan JuanArgentinaUniversidad Nacional de San Juan. Facultad de Ingeniería. Departamento de Ingeniería de Minas.Instituto de Investigaciones Minera

Deep Hubble Space Telescope Imaging of IC 1613 II. The Star Formation History

We present deep HST WFPC2 imaging of the Local Group dwarf irregular galaxy IC 1613. The photometry is the deepest to date for an isolated dwarf irregular galaxy. The resulting color-magnitude diagram (CMD) is analyzed using three different methods to derive a star formation history (SFH). All three find an enhanced star formation rate (SFR), from 3 to 6 Gyr ago, and similar age-metallicity relationships (AMR). A comparison of the newly observed outer field with an earlier studied central field of IC 1613 shows that the SFR in the outer field has been significantly depressed during the last Gyr. This implies that the optical scale length of the galaxy has been decreasing with time and that comparison of galaxies at intermediate redshift with present day galaxies should take this effect into account. We find strong similarities between IC 1613 and the more distant Milky Way dSph companions in that all are dominated by star formation at intermediate ages. In particular, the SFH and AMR for IC 1613 and Leo I are indistinguishable. This implies that dIrr galaxies cannot be distinguished from dSphs by their intermediate age stellar populations. This type of a SFH may also be evidence for slower or suppressed early star formation in dwarf galaxies due to photoionization after the reionization of the universe by background radiation. Assuming that IC 1613 is typical of a dIrr evolving in isolation, since most of the star formation occurs at intermediate ages, these dwarf systems cannot be responsible for the fast chemical enrichment of the IGM which is seen at high redshift. There is no evidence for any large amplitude bursts of star formation in IC 1613, and we find it highly unlikely that analogs of IC 1613 have contributed to the excess of faint blue galaxies in existing galaxy redshift surveys.Comment: 32 pages, including 1 table and 17 figures, accepted for publication in the Astrophysical Journal October 10, 2003 issu

Predictors of CD34+ cell mobilization and collection in adult men with germ cell tumors: implications for the salvage treatment strategy

BACKGROUND: High-dose chemotherapy with tandem or triple carboplatin and etoposide course is currently the first curative choice for relapsing GCT. The collection of an adequate amount of hematopoietic (CD34(+)) stem cells is a priority. PATIENTS AND METHODS: We analyzed data of patients who underwent HDCT at 2 referral institutions. Chemotherapy followed by myeloid growth factors was applied in all cases. Uni- and multivariable models were used to evaluate the association between 2 prespecified variables and mobilization parameters. Analyses included only the first mobilizing course of chemotherapy and mobilization failures. RESULTS: A total of 116 consecutive patients underwent a mobilization attempt from December 1995 to November 2012. Mobilizing regimens included cyclophosphamide (CTX) 7 gr/m(2) (n = 39), cisplatin, etoposide, and ifosfamide (PEI) (n = 42), paclitaxel, cisplatin, and gemcitabine (TPG) (n = 11), and mixed regimens (n = 24). Thirty-seven percent were treated in first-line, 50% (n = 58) in second-line, 9.5% (n = 11) and 3.4% (n = 4) in third- and fourth-line settings, respectively. Six patients did not undergo HDCT because they were poor mobilizers, 2 in first- and second-line (1.9%), and 4 beyond the second-line (26.7%). In the multivariable model, third-line or later setting was associated with a lower CD34(+) cell peak/μL (P = .028) and a lower total CD34(+)/kg collected (P = .008). The latter was also influenced by the type of mobilizing regimen (P < .001). CONCLUSION: A decline in significant mobilization parameters was found, primarily depending on the pretreatment load. Results lend support to the role of CD34(+) cell mobilization in the therapeutic algorithm of relapsing GCT, for whom multiple HDCT courses are still an option, and potentially a cure

WFPC2 Observations of Leo A: A Predominantly Young Galaxy within the Local Group

The unprecedented detail of the WFPC2 colour-magnitude diagrams of the resolved stellar population of Leo A presented here allows us to determine a new distance and an accurate star formation history for this extremely metal-poor Local Group dwarf irregular galaxy. From the position of the red clump, the helium-burning blue loops and the tip of the red giant branch, we obtain a distance modulus, m-M=24.2+/-0.2, or 690 +/- 60 kpc, which places Leo A firmly within the Local Group. Our interpretation of these features in the WFPC2 CMDs at this new distance based upon extremely low metallicity (Z=0.0004) theoretical stellar evolution models suggests that this galaxy is predominantly young, i.e. <2 Gyr old. A major episode of star formation 900 - 1500 Gyr ago can explain the red clump luminosity and also fits in with our interpretation of the number of anomalous Cepheid variable stars seen in this galaxy. We cannot rule out the presence of an older, underlying globular cluster age stellar population with these data. However, using the currently available stellar evolution models, it would appear that such an older population is limited to no more than 10% of the total star formation to have occured in this galaxy. Leo A provides a nearby laboratory for studying young metal poor stars and investigations of metal-poor galaxy evolution, such as is supposed to occur for larger systems at intermediate and high redshifts.Comment: 64 pages, 18 figures, 4 tables accepted for publication in the Astronomical Journal (Sept. 98

Design of Approaches for Dependability and Initial Prototypes

The aim of CONNECT is to achieve universal interoperability between heterogeneous Networked Systems. For this, the non-functional properties required at each side of the connection going to be established must be fulfilled. By the one inclusive term "CONNECTability" we comprehend properties belonging to all four non-functional concerns of interest for CONNECT, namely dependability, performance, security and trust. We model such properties in conformance with a meta-model which establishes the relevant concepts and their relations. Then, building on the conceptual models proposed in the first year in Deliverable D5.1, in this document we present the approaches developed for assuring CONNECTability both at synthesis time and at runtime. The contributions include: the Dependability&Performance analysis Enabler, for which we release a modular architecture supporting stochastic verification and state-based analysis; incremental verification and event-based monitoring for runtime analysis; a model-based approach to interoperable trust management; the Security-by-Contract-with-Trust framework, which guarantees and enforces the expected trust levels and security policies