Challenging Common Assumptions in the Unsupervised Learning of Disentangled Representations

The key idea behind the unsupervised learning of disentangled representations is that real-world data is generated by a few explanatory factors of variation which can be recovered by unsupervised learning algorithms. In this paper, we provide a sober look at recent progress in the field and challenge some common assumptions. We first theoretically show that the unsupervised learning of disentangled representations is fundamentally impossible without inductive biases on both the models and the data. Then, we train more than 12000 models covering most prominent methods and evaluation metrics in a reproducible large-scale experimental study on seven different data sets. We observe that while the different methods successfully enforce properties ``encouraged'' by the corresponding losses, well-disentangled models seemingly cannot be identified without supervision. Furthermore, increased disentanglement does not seem to lead to a decreased sample complexity of learning for downstream tasks. Our results suggest that future work on disentanglement learning should be explicit about the role of inductive biases and (implicit) supervision, investigate concrete benefits of enforcing disentanglement of the learned representations, and consider a reproducible experimental setup covering several data sets

Content Selection for Timeline Generation from Single History Articles

This thesis investigates the problem of content selection for timeline generation from single history articles. While the task of timeline generation has been addressed before, most previous approaches assume the existence of a large corpus of history articles from the same era. They exploit the fact that salient information is likely to be mentioned multiple times in such corpora. However, large resources of this kind are only available for historical events that happened in the most recent decades. In this thesis, I present approaches which can be used to create history timelines for any historical period, even for eras such as the Middle Ages, for which no large corpora of supplementary text exist. The thesis first presents a system that selects relevant historical figures in a given article, a task which is substantially easier than full timeline generation. I show that a supervised approach which uses linguistic, structural and semantic features outperforms a competitive baseline on this task. Based on the observations made in this initial study, I then develop approaches for timeline generation. I find that an unsupervised approach that takes into account the article's subject area outperforms several supervised and unsupervised baselines. A main focus of this thesis is the development of evaluation methodologies and resources, as no suitable corpora existed when work began. For the initial experiment on important historical figures, I construct a corpus of existing timelines and textual articles, and devise a method for evaluating algorithms based on this resource. For timeline generation, I present a comprehensive evaluation methodology which is based on the interpretation of the task as a special form of single-document summarisation. This methodology scores algorithms based on meaning units rather than surface similarity. Unlike previous semantic-units-based evaluation methods for summarisation, my evaluation method does not require any manual annotation of system timelines. Once an evaluation resource has been created, which involves only annotation of the input texts, new timeline generation algorithms can be tested at no cost. This crucial advantage should make my new evaluation methodology attractive for the evaluation of general single-document summaries beyond timelines. I also present an evaluation resource which is based on this methodology. It was constructed using gold-standard timelines elicited from 30 human timeline writers, and has been made publicly available. This thesis concentrates on the content selection stage of timeline generation, and leaves the surface realisation step for future work. However, my evaluation methodology is designed in such a way that it can in principle also quantify the degree to which surface realisation is successful

Quantum Algorithms for Quantum Chemistry and Quantum Materials Science

As we begin to reach the limits of classical computing, quantum computing has emerged as a technology that has captured the imagination of the scientific world. While for many years, the ability to execute quantum algorithms was only a theoretical possibility, recent advances in hardware mean that quantum computing devices now exist that can carry out quantum computation on a limited scale. Thus, it is now a real possibility, and of central importance at this time, to assess the potential impact of quantum computers on real problems of interest. One of the earliest and most compelling applications for quantum computers is Feynman’s idea of simulating quantum systems with many degrees of freedom. Such systems are found across chemistry, physics, and materials science. The particular way in which quantum computing extends classical computing means that one cannot expect arbitrary simulations to be sped up by a quantum computer, thus one must carefully identify areas where quantum advantage may be achieved. In this review, we briefly describe central problems in chemistry and materials science, in areas of electronic structure, quantum statistical mechanics, and quantum dynamics that are of potential interest for solution on a quantum computer. We then take a detailed snapshot of current progress in quantum algorithms for ground-state, dynamics, and thermal-state simulation and analyze their strengths and weaknesses for future developments

Phthalate Exposure During the Prenatal and Lactational Period Increases the Susceptibility to Rheumatoid Arthritis in Mice

The prenatal and early postnatal period is highly sensitive to environmental exposures that may interfere with the developmental programming of the immune system leading to an altered disease risk in later life. To clarify the role of early influences in activation or exacerbation of autoimmune diseases like rheumatoid arthritis (RA) we investigated the effect of maternal exposure during the prenatal and lactational period of DBA/1 mice to the plasticizer benzyl butyl phthalate (BBP) on the development of RA in the offspring. Using a mild collagen-induced arthritis (CIA) model, maternal BBP-exposure increased both the prevalence and the severity of RA in the progeny compared to un-exposed dams. Additionally, maternal BBP exposure led to elevated serum IgG1 and IgG2a level in the offspring and increased the IFN-g and IL-17 release from collagen-re-stimulated spleen cells. Transcriptome analysis of splenocytes isolated from 3-week-old pups before RA-induction revealed considerable changes in gene expression in the offspring from BBP-exposed dams. Among them were regulator of G-protein signaling 1 (rgs1), interleukin-7 receptor (il-7r) and CXC chemokine 4 (cxcr4), all genes that have previously been described as associated with RA pathology. In summary, our results demonstrate that perinatal exposure to BBP increases the susceptibility of the offspring to RA, probably via a phthalate-induced disturbed regulation of RA-relevant genes or signaling pathway

Quantum Algorithms for Quantum Chemistry and Quantum Materials Science

As we begin to reach the limits of classical computing, quantum computing has emerged as a technology that has captured the imagination of the scientific world. While for many years, the ability to execute quantum algorithms was only a theoretical possibility, recent advances in hardware mean that quantum computing devices now exist that can carry out quantum computation on a limited scale. Thus, it is now a real possibility, and of central importance at this time, to assess the potential impact of quantum computers on real problems of interest. One of the earliest and most compelling applications for quantum computers is Feynman’s idea of simulating quantum systems with many degrees of freedom. Such systems are found across chemistry, physics, and materials science. The particular way in which quantum computing extends classical computing means that one cannot expect arbitrary simulations to be sped up by a quantum computer, thus one must carefully identify areas where quantum advantage may be achieved. In this review, we briefly describe central problems in chemistry and materials science, in areas of electronic structure, quantum statistical mechanics, and quantum dynamics that are of potential interest for solution on a quantum computer. We then take a detailed snapshot of current progress in quantum algorithms for ground-state, dynamics, and thermal-state simulation and analyze their strengths and weaknesses for future developments