Quantum skyrmions and the destruction of long-range antiferromagnetic order in the high-Tc superconductors La(2-x)Sr(x)CuO(4) and YBa(2)Cu(3)O(6+x)

We study the destruction of the antiferromagnetic order in the high-Tc superconductors La(2-x)Sr(x)CuO(4) and YBa(2)Cu(3)O(6+x) in the framework of the CP1-nonlinear sigma model formulation of the 2D quantum Heisenberg antiferromagnet. The dopants are introduced as independent fermions with appropriate dispersion relations determined by the shape of the Fermi surface. The energy of skyrmion topological defects, which are shown to be introduced by doping, is used as an order parameter for antiferromagnetic order. We obtain analytic expressions for this as a function of doping which allow us to plot the curves T_N(x_c)\times x_c and M(x)\times x, for both YBCO and LSCO, in good quantitative agreement with the experimental data.Comment: 4 pages, revtex, 5 embeeded figure

Charge pairing, superconducting transition and supersymmetry in high-temperature cuprate superconductors

We propose a model for high-T$_{c}$ superconductors, valid for $0\leq\delta\leq\delta_{SC}$, that includes both the spin fluctuations of the Cu$^{++}$ magnetic ions and of the O$^{--}$ doped holes. Spin-charge separation is taken into account with the charge of the doped holes being associated to quantum skyrmion excitations (holons) of the Cu$^{++}$ spin background. The holon effective interaction potential is evaluated as a function of doping, indicating that Cooper pair formation is determined by the competition between the spin fluctuations of the Cu$^{++}$ background and of spins of the O$^{--}$ doped holes (spinons). The superconducting transition occurs when the spinon fluctuations dominate, thereby reversing the sign of the interaction. At this point ($\delta = \delta_{SC}$), the theory is supersymmetric at short distances and, as a consequence, the leading order results are not modified by radiative corrections. The critical doping parameter for the onset of superconductivity at T=0 is obtained and found to be a universal constant determined by the shape of the Fermi surface. Our theoretical values for $\delta_{SC}$ are in good agreement with the experiment for both LSCO and YBCO.Comment: RevTex, 4 pages, no figure

First step in the nuclear inverse Kohn-Sham problem: From densities to potentials

Nuclear density functional theory (DFT) plays a prominent role in the understanding of nuclear structure, being the approach with the widest range of applications. Hohenberg and Kohn theorems warrant the existence of a nuclear energy density functional (EDF), yet its form is unknown. Current efforts to build a nuclear EDF are hindered by the lack of a strategy for systematic improvement. In this context, alternative approaches should be pursued and, so far, an unexplored avenue is that related to the inverse DFT problem. DFT is based on the one-to-one correspondence between Kohn-Sham (KS) potentials and densities. The exact EDF produces the exact density, so that from the knowledge of experimental or ab initio densities one may deduce useful information through reverse engineering. The idea has already been proved to be useful in the case of electronic systems. The general problem should be dealt with in steps, and the objective of the present work is to focus on testing algorithms to extract the Kohn-Sham potential within the simplest ansatz from the knowledge of the experimental neutron and proton densities. We conclude that, while robust algorithms exist, the experimental densities present some critical aspects. Finally, we provide some perspectives for future works

Are large carnivores the real issue? Solutions for improving conflict management through stakeholder participation

Social conflicts around large carnivores are increasing in Europe, often associated to the species expansion into human-modified and agricultural landscapes. Large carnivores can be seen as an added value by some but as a source of difficulties by others, depending on different val-ues, attitudes, livelihoods, and everyday activities. Therefore, the effective involvement of the different interest groups is important to identify and shape tailored solutions that can potentially be implemented, complementing top-down approaches that might, on their own, result in lack of implementation and buy-in. To improve dialogue in conflictual situations, as part of a European project promoted by the European Parliament, we assessed the practical implementation of participatory processes in three sample areas in Europe where wolves and bears have recently been increasingly impacting human activities. Our results demonstrate that collaboration among different and generally contrasting groups is possible. Even in situations where large-carnivore impacts were seen as unsatisfactorily managed for many years, people were still willing and eager to be involved in alternative discussion processes hoping this would lead to concrete solutions. An important and common highlight among the three study areas was that all the management interventions agreed upon shared the general scope of improving the conditions of the groups most impacted by large carnivores. The process showed the importance of building trust and supporting dialogue for knowledge co-production and mitigation of conflicts between stakeholders and that controversial environmental issues have the potential to trigger a meaningful dialogue about broader societal issues. The direct involvement and support of competent authorities, as well as the upscaling of this process at larger administrative and social scales, remain important challenges

Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer

BACKGROUND: Recent evidence suggests that bone-related parameters are the main prognostic factors for overall survival in advanced prostate cancer (PCa), with elevated circulating levels of alkaline phosphatase (ALP) thought to reflect the dysregulated bone formation accompanying distant metastases. We have identified that PCa cells express ALPL, the gene that encodes for tissue nonspecific ALP, and hypothesised that tumour-derived ALPL may contribute to disease progression. METHODS: Functional effects of ALPL inhibition were investigated in metastatic PCa cell lines. ALPL gene expression was analysed from published PCa data sets, and correlated with disease-free survival and metastasis. RESULTS: ALPL expression was increased in PCa cells from metastatic sites. A reduction in tumour-derived ALPL expression or ALP activity increased cell death, mesenchymal-to-epithelial transition and reduced migration. Alkaline phosphatase activity was decreased by the EMT repressor Snail. In men with PCa, tumour-derived ALPL correlated with EMT markers, and high ALPL expression was associated with a significant reduction in disease-free survival. CONCLUSIONS: Our studies reveal the function of tumour-derived ALPL in regulating cell death and epithelial plasticity, and demonstrate a strong association between ALPL expression in PCa cells and metastasis or disease-free survival, thus identifying tumour-derived ALPL as a major contributor to the pathogenesis of PCa progression.British Journal of Cancer advance online publication, 22 December 2016; doi:10.1038/bjc.2016.402 www.bjcancer.com

The Effect of Transposable Element Insertions on Gene Expression Evolution in Rodents

Background:Many genomes contain a substantial number of transposable elements (TEs), a few of which are known to be involved in regulating gene expression. However, recent observations suggest that TEs may have played a very important role in the evolution of gene expression because many conserved non-genic sequences, some of which are know to be involved in gene regulation, resemble TEs. Results:Here we investigate whether new TE insertions affect gene expression profiles by testing whether gene expression divergence between mouse and rat is correlated to the numbers of new transposable elements inserted near genes. We show that expression divergence is significantly correlated to the number of new LTR and SINE elements, but not to the numbers of LINEs. We also show that expression divergence is not significantly correlated to the numbers of ancestral TEs in most cases, which suggests that the correlations between expression divergence and the numbers of new TEs are causal in nature. We quantify the effect and estimate that TE insertion has accounted for ~20% (95% confidence interval: 12% to 26%) of all expression profile divergence in rodents. Conclusions:We conclude that TE insertions may have had a major impact on the evolution of gene expression levels in rodents

Invariant Differential Operators and Characters of the AdS_4 Algebra

The aim of this paper is to apply systematically to AdS_4 some modern tools in the representation theory of Lie algebras which are easily generalised to the supersymmetric and quantum group settings and necessary for applications to string theory and integrable models. Here we introduce the necessary representations of the AdS_4 algebra and group. We give explicitly all singular (null) vectors of the reducible AdS_4 Verma modules. These are used to obtain the AdS_4 invariant differential operators. Using this we display a new structure - a diagram involving four partially equivalent reducible representations one of which contains all finite-dimensional irreps of the AdS_4 algebra. We study in more detail the cases involving UIRs, in particular, the Di and the Rac singletons, and the massless UIRs. In the massless case we discover the structure of sets of 2s_0-1 conserved currents for each spin s_0 UIR, s_0=1,3/2,... All massless cases are contained in a one-parameter subfamily of the quartet diagrams mentioned above, the parameter being the spin s_0. Further we give the classification of the so(5,C) irreps presented in a diagramatic way which makes easy the derivation of all character formulae. The paper concludes with a speculation on the possible applications of the character formulae to integrable models.Comment: 30 pages, 4 figures, TEX-harvmac with input files: amssym.def, amssym.tex, epsf.tex; version 2 1 reference added; v3: minor corrections; v.4: minor corrections, v.5: minor corrections to conform with version in J. Phys. A: Math. Gen; v.6.: small correction and addition in subsections 4.1 & 4.

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1

Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis is the myofibroblast, and fibroblast to myofibroblast differentiation is probably a crucial event. The cytokine TGF-β1 is reportedly the most important regulator of myofibroblastic differentiation in other species. The aim of this study was to isolate and characterise renal fibroblasts from cadaverous kidney tissue of cats with and without CKD, and to investigate the transcriptional response to TGF-β1

High resolution spectroscopic follow-up of the most metal-poor candidates from SkyMapper DR1.1

© 2021 The Author(s). Published by Oxford University Press on behalf of Royal Astronomical Society. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1093/mnras/stab2001We present chemical abundances for 21 elements (from Li to Eu) in 150 metal-poor Galactic stars spanning -4.1 -3.5. Of the 20 objects for which we could measure nitrogen, 11 are nitrogen-enhanced metal-poor (NEMP) stars. Within our sample, the high NEMP fraction (55 per cent ± 21 per cent) is compatible with the upper range of predicted values (between 12 per cent and 35 per cent). The chemical abundance ratios [X/Fe] versus [Fe/H] exhibit similar trends to previous studies of metal-poor stars and Galactic chemical evolution models. We report the discovery of nine new r-I stars, four new r-II stars, one of which is the most metal-poor known, nine low-α stars with [α/Fe] ≤ 0.15 as well as one unusual star with [Zn/Fe] = +1.4 and [Sr/Fe] = +1.2 but with normal [Ba/Fe]. Finally, we combine our sample with literature data to provide the most extensive view of the early chemical enrichment of the Milky Way Galaxy.Peer reviewe