The formation of professional foreign language competence as an integral part of the cultural background of new generation Russian entrepreneurs

The purpose of this paper is to highlight the importance of professional foreign language competence as part of entrepreneurs' cultural background in today's Russia. The article focuses on improving the education of Russian businesspeople through the integration of a professional foreign language course and the disciplines of their university major. The authors examine their own experience in searching for the most effective teaching tools, self-study evaluation tools including. The outcomes gained indicate that the modular interdisciplinary design of suggested training courses may have a positive impact on entrepreneurs' job performance

Electrophoretic Mobility of Red Blood Cells and Micronucleus Test in Exfoliated Buccal Cells as Stress Intensity Markers

The purpose of this study was to investigate the electrophoretic mobility of red blood cells (RBCs), cytomorphological and cytogenetical indices in exfoliated buccal epithelial cells of rats during the development of stress reaction. Experiments were carried out on 60 white non-pedigree pubescent rats weighing 180-220g. Both the single and the repeated adrenalin injections provoked a decrease in the level of the RBC electrophoretic mobility. With a single adrenalin injection, the changes in RBC electrophoretic mobility are not so abrupt, with the subsequent development of the adaptive response and reparation of cytogenetic damage. With repeated adrenalin injections, the changes in RBC electrophoretic mobility are abrupt, and the number of pathological epithelial cells increases

The formation of professional foreign language competence as an integral part of the cultural background of new generation Russian entrepreneurs

The purpose of this paper is to highlight the importance of professional foreign language competence as part of entrepreneurs' cultural background in today's Russia. The article focuses on improving the education of Russian businesspeople through the integration of a professional foreign language course and the disciplines of their university major. The authors examine their own experience in searching for the most effective teaching tools, self-study evaluation tools including. The outcomes gained indicate that the modular interdisciplinary design of suggested training courses may have a positive impact on entrepreneurs' job performance

Measurement of Patient-Derived Glioblastoma Cell Response to Temozolomide Using Fluorescence Lifetime Imaging of NAD(P)H

Personalized strategies in glioblastoma treatment are highly necessary. One of the possible approaches is drug screening using patient-derived tumor cells. However, this requires reliable methods for assessment of the response of tumor cells to treatment. Fluorescence lifetime imaging microscopy (FLIM) is a promising instrument to detect early cellular response to chemotherapy using the autofluorescence of metabolic cofactors. Here, we explored FLIM of NAD(P)H to evaluate the sensitivity of patient-derived glioma cells to temozolomide (TMZ) in vitro. Our results demonstrate that the more-responsive cell cultures displayed the longest mean fluorescence lifetime τm after TMZ treatment due to an increase in the protein-bound NAD(P)H fraction α2 associated with a shift to oxidative phosphorylation. The cell cultures that responded poorly to TMZ had generally shorter τm, i.e., were more glycolytic, and showed no or insignificant changes after treatment. The FLIM data correlate well with standard measurements of cellular drug response—cell viability and proliferation index and clinical response in patients. Therefore, FLIM of NAD(P)H provides a highly sensitive, label-free assay of treatment response directly on patient-derived glioblastoma cells and can become an innovative platform for individual drug screening for patients