228 research outputs found
Comment on: Beverly et al. Do older adults aged 60-75 years benefit from diabetes behavioral interventions? Diabetes Care
High glucose and hypoxia-induced damage in the inner blood retinal barrier is counteracted by thiamine supplementation
miRNAs shuttled by extracellular vesicles from diabetic subjects induce features of retinopathy in vitro
A 5-Year Randomized Controlled Study of Learning, Problem Solving Ability, and Quality of Life Modifications in People With Type 2 Diabetes Managed by Group Care
OBJECTIVE—To study time course changes in knowledge, problem solving ability, and quality of life in patients with type 2 diabetes managed by group compared with individual care and education.
RESEARCH DESIGN AND METHODS—We conducted a 5-year randomized controlled clinical trial of continuing systemic education delivered by group versus individual diabetes care in a hospital-based secondary care diabetes unit. There were 120 patients with non–insulin-treated type 2 diabetes enrolled and randomly allocated to group or individual care. Eight did not start and 28 did not complete the study. The main outcome measures were knowledge of diabetes, problem solving ability, quality of life, HbA1c, BMI, and HDL cholesterol.
RESULTS—Knowledge of diabetes and problem solving ability improved from year 1 with group care and worsened among control subjects (P < 0.001 for both). Quality of life improved from year 2 with group care but worsened with individual care (P < 0.001). HbA1c level progressively increased over 5 years among control subjects (+1.7%, 95% CI 1.1–2.2) but not group care patients (+0.1%, −0.5 to 0.4), in whom BMI decreased (−1.4, −2.0 to −0.7) and HDL cholesterol increased (+0.14 mmol/l, 0.07–0.22).
CONCLUSIONS—Adults with type 2 diabetes can acquire specific knowledge and conscious behaviors if exposed to educational procedures and settings tailored to their needs. Traditional one-to-one care, although delivered according to optimized criteria, is associated with progressive deterioration of knowledge, problem solving ability, and quality of life. Better cognitive and psychosocial results are associated with more favorable clinical outcomes
Thiamine transporter 2 is involved in high glucose-induced damage and altered thiamine availability in cell models of diabetic retinopathy
Gesti e azioni di cura educativa. La progettazione educativa nell’ambito delle malattie croniche
Molecular and functional characterization of circulating extracellular vesicles from diabetic patients with and without retinopathy and healthy subjects
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