Immunogenicity Is Not Improved by Increased Antigen Dose or Booster Dosing of Seasonal Influenza Vaccine in a Randomized Trial of HIV Infected Adults

The risk of poor vaccine immunogenicity and more severe influenza disease in HIV necessitate strategies to improve vaccine efficacy.A randomized, multi-centered, controlled, vaccine trial with three parallel groups was conducted at 12 CIHR Canadian HIV Trials Network sites. Three dosing strategies were used in HIV infected adults (18 to 60 years): two standard doses over 28 days, two double doses over 28 days and a single standard dose of influenza vaccine, administered prior to the 2008 influenza season. A trivalent killed split non-adjuvanted influenza vaccine (Fluviral™) was used. Serum hemagglutinin inhibition (HAI) activity for the three influenza strains in the vaccine was measured to assess immunogenicity.297 of 298 participants received at least one injection. Baseline CD4 (median 470 cells/µL) and HIV RNA (76% of patients with viral load <50 copies/mL) were similar between groups. 89% were on HAART. The overall immunogenicity of influenza vaccine across time points and the three influenza strains assessed was poor (Range HAI ≥ 40 =  31-58%). Double dose plus double dose booster slightly increased the proportion achieving HAI titre doubling from baseline for A/Brisbane and B/Florida at weeks 4, 8 and 20 compared to standard vaccine dose. Increased immunogenicity with increased antigen dose and booster dosing was most apparent in participants with unsuppressed HIV RNA at baseline. None of 8 serious adverse events were thought to be immunization-related.Even with increased antigen dose and booster dosing, non-adjuvanted influenza vaccine immunogenicity is poor in HIV infected individuals. Alternative influenza vaccines are required in this hyporesponsive population.ClinicalTrials.gov NCT00764998

The clinical effectiveness of an integrated multidisciplinary evidence-based program to prevent intraoperative pressure injuries in high-risk children undergoing long-duration surgical procedures: a quality improvement study

The prevention of hospital-acquired pressure injuries (HAPIs) in children undergoing long-duration surgical procedures is of critical importance due to the potential for catastrophic sequelae of these generally preventable injuries for the child and their family. Long-duration surgical procedures in children have the potential to result in high rates of HAPI due to physiological factors and the difficulty or impossibility of repositioning these patients intraoperatively. We developed and implemented a multi-modal, multi-disciplinary translational HAPI prevention quality improvement program at a large European Paediatric University Teaching Hospital. The intervention comprised the establishment of wound prevention teams, modified HAPI risk assessment tools, specific education, and the use of prophylactic dressings and fluidized positioners during long-duration surgical procedures. As part of the evaluation of the effectiveness of the program in reducing intraoperative HAPI, we conducted a prospective cohort study of 200 children undergoing long-duration surgical procedures and compared their outcomes with a matched historical cohort of 200 children who had undergone similar surgery the previous year. The findings demonstrated a reduction in HAPI in the intervention cohort of 80% (p &lt; 0.01) compared to the comparator group when controlling for age, pathology, comorbidity, and surgical duration. We believe that the findings demonstrate that it is possible to significantly decrease HAPI incidence in these highly vulnerable children by using an evidence-based, multi-modal, multidisciplinary HAPI prevention strategy

Plan de marketing de nuevo programa LAR de Lider.ar

Fil: Ragni, Marina. Universidad de San Andrés. Escuela de Negocios; Argentina.Lomé, Marian

Consulenza tecnica per esecuzione di prove sperimentali a taglio per la valutazione del comportamento termomeccanico dell’incollaggio di rivestimenti in poliuretano elastomerico

Svolgimento di prove sperimentali per la caratterizzazione della resistenza a taglio di giunzioni incollate metallo-elastomero al fine di valutare: a) Effetto della tipologia di sabbiatura degli aderendi, su adesivo Thixon 406; b) Effetto del condizionamento, sull’adesivo Thixon 406; c) Effetto del tipo di adesivo: Thixon 406 vs Thixon 422

Analisi e procedura di collaudo a resistenza di giunzioni incollate con adesivo UV in box doccia

Analizzare e definire una procedura di collaudo a resistenza (“Norma Novellini”) delle giunzioni incollate con adesivo UV nei box doccia

CARATTERIZZAZIONE A TORSIONE DI PROVINI DI CONDUTTORE IN CAVO TRASPOSTO UTILIZZATI NEI TRASFORMATORI SECONDO LA NORMA SOT054

CARATTERIZZAZIONE A TORSIONE DI PROVINI DI CONDUTTORE IN CAVO TRASPOSTO UTILIZZATI NEI TRASFORMATORI SECONDO LA NORMA SOT05

Device for stabilizing wine and other vegetable beverages and the related stabilizing method

The invention refers to a continuous flow device for the removal of proteins, metals and other agents of instability of wine and vegetable beverages. The system is constitued by a tube containing inert support material, functionalized to increase its adsorption selectivity. The proposed system, working in continuous flow, determines a substantial reduction in treatment times, in waste production and ensure removing the causes of protein instability and oxidation in wine. Furthermore, the adsorbent material can be regenerated, guaranteeing more successive uses

Dispositivo per la stabilizzazione del vino ed altre bevande vegetali e relativo procedimento di stabilizzazione

L\u2019invenzione si riferisce ad un dispositivo a flusso continuo per la rimozione di proteine, metalli e altri agenti di instabilit\ue0 del vino e bevande vegetali. Il sistema \ue8 costituito da un tubo contenente materiale inerte di supporto, funzionalizzato per aumentarne la selettivit\ue0 di adsorbimento. Il sistema proposto, lavorando in flusso continuo, determina una riduzione sostanziale dei tempi di trattamento, della produzione degli scarti e la contemporanea possibilit\ue0 di rimuovere le cause di instabilit\ue0 proteica e delle ossidazioni nel vino. Inoltre, il materiale adsorbente utilizzato pu\uf2 essere rigenerato garantendo pi\uf9 utilizzi successivi