Tamizaje auditivo neonatal: Guía para el diagnóstico temprano

Congenital sensorineural hearing loss is one of the most frequent pathologies of the newborn. To carry out the diagnosis and early detection of this pathology in the pediatric population, specialized audiological tests are required, such as otoacoustic emissions and auditory evoked potentials. Therefore, it is important to have a guide to identify and detect those patients with suspected congenital sensorineural hearing loss.La hipoacusia neurosensorial congénita es una de las patologías más frecuentes del recién nacido. Para realizar el diagnóstico y la detección temprana de dicha patología en la población pediátrica se requiere de exámenes audiológicos especializados como las emisiones otoacústicas y los potenciales evocados auditivos. Por ello, es importante tener una guía para identificar y detectar aquellos pacientes con sospecha de hipoacusia neurosensorial congénita. &nbsp

Serverless Computing: A Security Perspective

Serverless Computing is a virtualisation-related paradigm that promises to simplify application management and to solve one of the last architectural challenges in the field: scale down. The implied cost reduction, coupled with a simplified management of underlying applications, are expected to further push the adoption of virtualisation-based solutions, including cloud-computing. However, in this quest for efficiency, security is not ranked among the top priorities, also because of the (misleading) belief that current solutions developed for virtualised environments could be applied to this new paradigm. Unfortunately, this is not the case, due to the highlighted idiosyncratic features of serverless computing. In this paper, we review the current serverless architectures, abstract their founding principles, and analyse them from the point of view of security. We show the security shortcomings of the analysed serverless architectural paradigms, and point to possible countermeasures. We believe that our contribution, other than being valuable on its own, also paves the way for further research in this domain, a challenging and relevant one for both industry and academia

DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation.

An algorithm assessing the methylation levels of 353 informative CpG sites in the human genome permits accurate prediction of the chronologic age of a subject. Interestingly, when there is discrepancy between the predicted age and chronologic age (age acceleration or AgeAccel ), patients are at risk for morbidity and mortality. Identification of infertile patients at risk for accelerated reproductive senescence may permit preventative action. This study aimed to assess the accuracy of the epigenetic clock concept in reproductive age women undergoing fertility treatment by applying the age prediction algorithm in peripheral (white blood cells [WBCs]) and follicular somatic cells (cumulus cells [CCs]), and to identify whether women with premature reproductive aging (diminished ovarian reserve) were at risk of AgeAccel in their age prediction. Results indicated that the epigenetic algorithm accurately predicts age when applied to WBCs but not to CCs. The age prediction of CCs was substantially younger than chronologic age regardless of the patient\u27s age or response to stimulation. In addition, telomeres of CCs were significantly longer than that of WBCs. Our findings suggest that CCs do not demonstrate changes in methylome-predicted age or telomere-length in association with increasing female age or ovarian response to stimulation

An individually fitted physical barrier device as a tool to restrict the birds’spatial access: can their use alter behavioral responses?

In this work we introduce an hp finite element method for two-dimensional Poisson problems on curved domains using curved elements. We obtain a priori  error estimates and define a local a posteriori error estimator of residual type.We show,  under appropriate assumptions about the curved domain, the globalreliability and the local efficiency of the esimator. More precisely, we prove that theestimator is equivalent to the energy norm of the error up to higher order terms. The equivalence constant of the efficiency estimate depends on the polynomial degree.We also present an hp adaptive algorithm and several numerical tests which show the performance of the adaptive strategy.Fil: Pellegrini, Stefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Marin, Raul Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Guzmán, Diego Alberto. Aarhus University. Aarhus Institute Of Advanced Studies.; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentin

Japanese quail classified by their permanence in proximity to a high or low density of conspecifics: a search for underpinning variables

Test of sociality in poultry is mainly based on the bird's individual ability to make quick social discriminations. In recent years, a density-related permanence (DRP) test has been developed that enables us to classify young birds (while in groups) according to their individual permanence in proximity to either a high or low density of conspecifics (HD or LD, respectively). Thus, the result of the classification depends not only on the bird's individual response but also on the outcome of the social interactions within the whole group. The birds' performance in DRP was associated with underlying differences in social responses of their individuals. Quails in homogeneous groups of LD residents responded with less compact groups and higher levels of agonistic interactions to the presence of an intruder and showed higher levels of agonistic interactions among cage-mates than the homogeneous groups of HD birds. An acute stressor also induced a higher corticosterone response in the LD birds than in their HD counterparts. The present study addressed the question of whether contrasting DRP performance by Japanese quail can also reflect underlying differences in fearfulness and social reinstatement responses. Thus, LD and HD categorized juvenile birds underwent one of the following tests: tonic immobility (TI), open-field (OF), or a one-way runway. Results showed that HD birds required more inductions and developed shorter responses (P ≤ 0.05) in the TI test and walked more, faster, and greater distances in the OF (P ≤ 0.05) than their LD counterparts. No differences between groups were found in short social reinstatement responses. The present findings suggest that underlying fearfulness is lower in the HD than in the LD birds. A reduced fearfulness could be regarded as an additional favorable trait of the HD-classified quail to cope with environmental challenging situations.Fil: Guzmán, Diego Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; ArgentinaFil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; ArgentinaFil: Marin, Raul Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; Argentin