A near-infrared study of AGB and red giant stars in the Leo I dSph galaxy

A near-infrared imaging study of the evolved stellar populations in the dwarf spheroidal galaxy Leo I is presented. Based on JHK observations obtained with the WFCAM wide-field array at the UKIRT telescope, we build a near-infrared photometric catalogue of red giant branch (RGB) and asymptotic giant branch (AGB) stars in Leo I over a 13.5 arcmin square area. The V-K colours of RGB stars, obtained by combining the new data with existing optical observations, allow us to derive a distribution of global metallicity [M/H] with average [M/H] = -1.51 (uncorrected) or [M/H] = -1.24 +/- 0.05 (int) +/- 0.15 (syst) after correction for the mean age of Leo I stars. This is consistent with the results from spectroscopy once stellar ages are taken into account. Using a near-infrared two-colour diagram, we discriminate between carbon- and oxygen-rich AGB stars and obtain a clean separation from Milky Way foreground stars. We reveal a concentration of C-type AGB stars relative to the red giant stars in the inner region of the galaxy, which implies a radial gradient in the intermediate-age (1-3 Gyr) stellar populations. The numbers and luminosities of the observed carbon- and oxygen-rich AGB stars are compared with those predicted by evolutionary models including the thermally-pulsing AGB phase, to provide new constraints to the models for low-metallicity stars. We find an excess in the predicted number of C stars fainter than the RGB tip, associated to a paucity of brighter ones. The number of O-rich AGB stars is roughly consistent with the models, yet their predicted luminosity function is extended to brighter luminosity. It appears likely that the adopted evolutionary models overestimate the C star lifetime and underestimate their K-band luminosity.Comment: MNRAS, accepte

New in vitro cellular model for molecular studies of retinitis pigmentosa

Retinitis pigmentosa (RP) is an inherited form of retinal degeneration characterized by primary rod photoreceptor cell death followed by cone loss. Mutations in several genes linked to the disease cause increased levels of cyclic guanosine monophosphate (cGMP) and calcium ion influxes. The purpose of this project was to develop a new in vitro photoreceptor degeneration model for molecular studies of RP. 661W cells were genetically modified to stably express the neural retina leucine zipper (NRL) transcription factor. One clone (661W-A11) was selected based on the expression of Nrl target genes. 661W-A11 showed a significant increase in expression of rod-specific genes but not of cone-specific genes, compared with 661W cells. Zaprinast was used to inhibit phosphodiesterase 6 (PDE6) activity to mimic photoreceptor degeneration in vitro. The activation of cell death pathways resulting from PDE6 inhibition was confirmed by detection of decreased viability and increased intracellular cGMP and calcium, as well as activation of protein kinase G (PKG) and calpains. In this new in vitro system, we validated the effects of previously published neuroprotective drugs. The 661W-A11 cells may serve as a new model for molecular studies of RP and for high-throughput drug screening

Molecular mechanisms underlying inherited photoreceptor degeneration as targets for therapeutic intervention

Retinitis pigmentosa (RP) is a form of retinal degeneration characterized by primary degeneration of rod photoreceptors followed by a secondary cone loss that leads to vision impairment and finally blindness. This is a rare disease with mutations in several genes and high genetic heterogeneity. A challenging effort has been the characterization of the molecular mechanisms underlying photoreceptor cell death during the progression of the disease. Some of the cell death pathways have been identified and comprise stress events found in several neurodegenerative diseases such as oxidative stress, inflammation, calcium imbalance and endoplasmic reticulum stress. Other cell death mechanisms appear more relevant to photoreceptor cells, such as high levels of cGMP and metabolic changes. Here we review some of the cell death pathways characterized in the RP mutant retina and discuss preclinical studies of therapeutic approaches targeting the molecular outcomes that lead to photoreceptor cell demise

Detecting Primordial Stars

We discuss the expected properties of the first stellar generations in the Universe. We find that it is possible to discern truly primordial populations from the next generation of stars by measuring the metallicity of high-z star forming objects. The very low background of the future James Webb Space Telescope (JWST) will enable it to image and study first-light sources at very high redshifts, whereas its relatively small collecting area limits its capability in obtaining spectra of z~10-15 first-light sources to either the bright end of their luminosity function or to strongly lensed sources. With a suitable investment of observing time JWST will be able to detect individual Population III supernovae, thus identifying the very first stars that formed in the Universe.Comment: [8 pages, 5 figures] Invited Talk, to appear in IMF@50: The Stellar Initial Mass Function Fifty Years Later, eds E. Corbelli, F. Palla, and H. Zinnecker (Dordrecht: Kluwer

The evolution of luminosity, colour and the mass-to-luminosity ratio of Galactic open clusters: comparison of discrete vs. continuous IMF models

(abridged) We found in previous studies that standard Simple Stellar Population (SSP) models are unable to describe or explain the colours of Galactic open clusters both in the visible and in the NIR spectral range. (...) We construct a numerical SSP-model, with an underlying Salpeter IMF, valid within an upper $m_u$ and lower $m_l$ stellar mass range, and with total masses $M_c=10^2...10^4\,m_\odot$ typical of open clusters. We assume that the mass loss from a cluster is provided by mass loss from evolved stars and by the dynamical evaporation of low-mass members due to two-body relaxation. The data for the latter process were scaled to the models from high-resolution N-body calculations. We also investigate how a change of the $m_l$-limit influences magnitudes and colours of clusters of a given mass and derive a necessary condition for a luminosity and colour flash. The discreteness of the IMF leads to bursts in magnitude and colour of model clusters at moments when red supergiants or giants appear and then die. The amplitude of the burst depends on the cluster mass and on the spectral range; it is strongly increased in the NIR compared to optical passbands. In the discrete case, variations of the parameter $m_l$ are able to substantially change the magnitude-age and $M/L$-age relations. For the colours, the lowering of $m_l$ considerably amplifies the discreteness effect. The influence of dynamical mass loss on colour and magnitude is weak, although it provides a change of the slopes of the considered relations, improving their agreement with observations. For the Galactic open clusters we determined luminosity and tidal mass independent of each other. The derived mass-to-luminosity ratio shows, on average, an increase with cluster age in the optical, but gradually declines with age in the NIR. The observed flash statistics can be used to constrain $m_l$ in open clusters.Comment: 15 pages, 13 figures, accepted for publication in Astronomy and Astrophysic

Life Products of Stars

We attempt to document complete energetic transactions of stars in their life. We calculate photon and neutrino energies that are produced from stars in their each phase of evolution from 1 to 8 M_sun, using the state-of-the-art stellar evolution code, tracing the evolution continuously from pre-main sequence gravitational contraction to white dwarfs. We also catalogue gravitational and thermal energies and helium, and heavier elements that are stored in stars and those ejected into interstellar space in each evolutionary phase.Comment: 26 pages, including 8 figures and 3 tables. Submitted to ApJ

On ionisation effects and abundance ratios in damped Lyman-alpha systems

The similarity between observed velocity structures of Al III and singly ionised species in damped Lyman-alpha systems (DLAs) suggests the presence of ionised gas in the regions where most metal absorption lines are formed. To explore the possible implications of ionisation effects we construct a simplified two-region model for DLAs consisting of an ionisation bounded region with an internal radiation field and a neutral region with a lower metal content. Within this framework we find that ionisation effects are important. If taken into account, the element abundance ratios in DLAs are quite consistent with those observed in Milky Way stars and in metal-poor H II regions in blue compact dwarf galaxies. In particular we cannot exclude the same primary N origin in both DLAs and metal-poor galaxies. From our models no dust depletion of heavy elements needs to be invoked; little depletion is however not excluded.Comment: to appear in "Evolution of Galaxies. I. Observational clues", Eds. J.M. Vilchez, G. Stasinska, Astrophysics and Space Science, in press. 5 pages, including 3 figure

The s-Process in Rotating Asymptotic Giant Branch Stars

(abridged) We model the nucleosynthesis during the thermal pulse phase of a rotating, solar metallicity AGB star of 3M_sun. Rotationally induced mixing during the thermal pulses produces a layer (~2E-5M_sun) on top of the CO-core where large amounts of protons and C12 co-exist. We follow the abundance evolution in this layer, in particular that of the neutron source C13 and of the neutron poison N14. In our AGB model mixing persists during the entire interpulse phase due to the steep angular velocity gradient at the core-envelope interface. We follow the neutron production during the interpulse phase, and find a resulting maximum neutron exposure of tau_max =0.04 mbarn^-1, which is too small to produce any significant s-process. In parametric models, we then investigate the combined effects of diffusive overshooting from the convective envelope and rotationally induced mixing. Models with overshoot and weaker interpulse mixing - as perhaps expected from more slowly rotating stars - yield larger neutron exposures. We conclude that the incorporation of rotationally induce mixing processes has important consequences for the production of heavy elements in AGB stars. Through a distribution of initial rotation rates it may lead to a natural spread in the neutron exposures obtained in AGB stars of a given mass - as appears to be required by observations. Our results suggest that both processes, diffusive overshoot and rotational mixing, may be required to obtain a consistent description of the s-process in AGB stars which fulfils all observational constraints. Finally, we find that mixing due to rotation within our current framework does increase the production of N15 in the partial mixing zone, however still falling short of what seems required by observations.Comment: 50 pages, 13 figures, ApJ in press, tentatively scheduled for v593 n2 August 20, 200