Aquello que me habita : el bosque nativo

El trabajo colectivo enriquece las miradas, la interdisciplinariedad las multiplica. En este proyecto, buscamos abrir el juego para pensar- reflexionar e imaginar aquello que nos habita referido a la temática del bosque nativo. Lo hacemos desde distintas disciplinas, en un mismo formato: el libro de artista. Aquí, percibimos con todos los sentidos que se abre un espacio, un lugar para habitar y ser, para dejar nuestras vivencias, experiencias, sensaciones y sentimientos; para dejar nuestra huella, esa marca que entre la estructura y la cognición, entre el juego y la experimentación, permiten que algo surja. Es un libro de artista donde, retomando las palabras de Oller Navarro, en El libro como obra plástica (2011), “su sentido se encuentra primero en el aspecto lúdico que representa la definición del libro”. Gran parte de los autores que participamos en esta propuesta formamos parte del equipo de investigación: “Interrelación de poéticas fronterizas. Producción, recepción y enseñanza del arte en espacios diversos con tecnologías del presente”. SECyT- UNC-2018-2021; otros son invitados especialistas de interés. Este libro, refleja la variedad y la inclusión. Variedad en cuanto naturaleza; el bosque, como espacio que nos habita y que habitamos. Finalmente, este espacio de encuentro en formato libro, nos permite una comunicación horizontal y respetuosa entre personas que trabajan en la Instalación inmersiva “Paisajes y sentidos. Americanismos en la lengua”

EXTREME THROMBOCYTOSIS IN CHRONIC MYELOID LEUKEMIA IN THE ERA OF TYROSINE KINASE INHIBITORS

Thrombocytosis is a common feature in chronic myeloproliferative diseases and contributes to an increased incidence of thrombotic and haemorrhagic events during the course of the disease. In chronic myeloid leukemia (CML) however, haemorrhagic and thrombotic complications even with marked thrombocytosis are rare (3% and 1% respectively)[1]. The incidence of thrombocytosis in CML is reported to be around 30 to 50%. Extreme thrombocytosis defined as a platelet count > 1.000 x 109/l is uncommon in CML as well as isolated thrombocytosis and, as reported for other chronic myeloproliferative diseases, acquired von Willebrand syndrome (avWs) might occur [2

Chlorambucil PLUS Rituximab As FRONT-LINE THERAPY in Elderly or Unfit Patients Affected by B-CELL Chronic Lymphocytic Leukemia: Results of A Single-Centre Retrospective Analysis

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Long-term follow up of frontline therapy with fludarabine and cyclophosphamide in chronic lymphocytic leukemia: impact of biological parameters on clinical outcome

It has not abstract because of its a lette

Role of flow-cytometric immunophenotyping in prediction of BCR/ABL1 gene rearrangement in adult B-cell acute lymphoblastic leukemia

We performed a retrospective analysis of 88 adult patients with B-ALL diagnosed in our center by a flow-cytometric assessment. Immunophenotypic expression of leukemic cells was explored by simultaneous evaluation of positivity, percentage of expressing cells and median fluorescence intensity (MFI). BCR/ABL1 fusion transcripts were assessed by RT-PCR analysis and were identified in 36 patients (40.9%). CD10 and CD34 were positive in the totality of BCR/ABL1-positive cases. Patients with gene rearrangement had a greater frequency of CD66c, CD13 and CD33 positivity compared with BCR/ABL1-negative cases. Moreover, BCR/ABL1-positive cases exhibited a greater median percentage and MFI values of CD13, CD33, CD66c, CD10, CD34 and CD25 expressions, but a lower median percentage and MFI values of CD38 and CD22 expressions than patients without gene rearrangement. Multivariate logistic regression analysis showed that CD10, CD38 and CD13 expressions were independent predictors for the presence of BCR/ABL1 rearrangement. Predictive probabilities of molecular occurrence based on these markers are proposed. \ua9 2017 International Clinical Cytometry Society

MTHFR polymorphisms involved in vitamin B12 deficiency associated with atrophic gastritis

Genetic polymorphisms affecting methylentetrahydrofolate reductase (MTHFR) activity may influence hematological and neurological dysfunction in cobalamin-deficient patients. We studied the prevalence of C677T and A1298C polymorphisms by analyzing genomic DNA in 30 cobalamin-deficient patients. No significant difference was found in 677 and 1298 genotype distribution with respect to hematological parameters, B12 and folate levels, and neurological symptoms. The two MTHFR polymorphisms were not protective against anemia or neurological dysfunction in patients with cobalamin deficiency; however, we found evidence of a significant increase in atrophic gastritis in the 677TT group (P = 0.009) but not for the 1298CC genotype. Based on observations that inadequate cobalamin intake and reduced MTHFR activity might be significant risk factors for gastric cancer, and the increased risk of gastric cancer shown in patients affected by atrophic gastritis, we speculate that concomitant atrophic gastritis and impaired MTHFR function could have a role in the development of gastric cancer

Aquello que (nos) habita

El trabajo que presentamos a continuación, forma parte de una propuesta mayor que inició en el año 2018. Por entonces, se fue gestando un primer libro arte/libro de artista (de carácter colectivo – colaborativo) en torno a premisas concretas: generar un espacio de encuentro e intercambio dialógico sobre una temática que nos atraviesa: el bosque nativo. De esta manera, y retomando lo trabajado en “Aquello que me habita – El Bosque Nativo”, el presente libro pretende dar continuidad a aquella experiencia, sumando nuevas miradas y conceptos que surgen a partir de la actividad colectiva, el intercambio de ideas y el encuentro dialógico con les otres. El tema que nos sigue convocando es la relación entre el hombre y el medio ambiente, su hábitat. De esta forma decidimos tomar el Bosque Nativo como eje vertebrador y catalizador de las reflexiones colectivo-colaborativas, las cuales se encuentran arraigadas a las propias biografías o experiencias de vida de cada une: los recuerdos de la infancia, las labores manuales, el trabajo minucioso de recolectar y clasificar semillas para su preservación, entre otros. Todas estas memorias constituyen un corpus conceptual que sirven de alimento para darle vida a este libro, el cual no pretende ser un compendio de anécdotas elegidas al azar, sino una suerte de nido o receptáculo de la existencia, que da cobijo a múltiples voces y desde el cual se construye sentido. En relación a esto último, coincidimos con Nicolas Bourriaud cuando indica que “las obras de arte ya no tienen como meta formar realidades imaginarias o utópicas, sino constituir modos de existencia o modelos de acción dentro de lo real ya existente.” Es en esa dirección que proponemos situar esta publicación.Fil: Hernández, Alejandra Fabiana. Universidad Nacional de Córdoba. Facultad de Artes. Departamento Académico de Artes Visuales; Argentina.Fil: Canesini, Belén. Universidad Nacional de Córdoba. Facultad de Artes. Departamento Académico de Artes Visuales; Argentina.Fil: Romagnoli, Carla. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Carpio, Sara Inés. Universidad Nacional de Córdoba. Facultad de Artes. Departamento Académico de Artes Visuales; Argentina.Fil: Marietti, Inés María. Universidad Nacional de Córdoba. Facultad de Artes. Departamento Académico de Artes Visuales; Argentina.Fil: Méndez, Belén. Universidad Nacional de Córdoba. Facultad de Artes; ArgentinaFil: Miranda, Adriana. Universidad Nacional de Córdoba. Facultad de Artes. Departamento Académico de Artes Visuales; Argentina

Comparison between oral and intravenous fludarabine plus cyclophosphamide regime as front-line therapy in patients affected by chronic lymphocytic leukaemia: influence of biological parameters on the clinical outcome

The fludarabine plus cyclophosphamide (FC) regimen was reported to be superior to chlorambucil or fludarabine alone in terms of complete response (CR), overall response (OR) and progression-free survival (PFS) in previously untreated patients with chronic lymphocytic leukaemia (CLL). In the present study, we compared the efficacy and toxicity of FC administered through oral and intravenous route in 65 untreated patients affected by advanced CLL. No statistical differences were noticed between the two routes of administration in terms of OR, PFS, time to re-treatment (TTR) and overall survival (OS) of analysed patients. We also assessed the influence on the clinical outcome of the mutation status of the immunoglobulin variable region heavy chain (IgVH) gene, of the cytogenetic abnormalities and of the expression of ZAP70 and CD38 in patients' primary samples. Among the 58 evaluable patients, 31 (53%) achieved a CR and 18 (31%) a partial response. The median PFS was 35 months, median TTR was 42 months and median OS was not reached after 45 months (range, 1-161). A significantly lower OR rate was noticed in patients with high-risk cytogenetic abnormalities (del 17p, del 11q). In this study, high-risk cytogenetic abnormalities and unmutated IgVH genes were independent predictors of TTR. These results underline the importance of biological stratifications in front-line treatment of CLL patients. We confirm that FC is an effective regimen with mild toxicities; it could be recommended for patients with low-risk biological parameters who represent, in our experience, about 30% of the total

The role of MTHFR and RFC1 polymorphisms on toxicity and outcome of adult patients with hematological malignancies treated with high-dose methotrexate followed by leucovorin rescue

In the last years, the influence of different genes involved in metabolism of chemotherapeutic agents has been studied. Methotrexate (MTX) is a key compound of chemotherapeutic regimens used in the treatment of acute lymphoblastic leukemia (ALL), primary central nervous system lymphoma (PCNSL) and Burkitt's lymphomas (BL). This study aims to evaluate the role of MTHFR C677T and A1298C polymorphisms and G80A reduced folate carrier gene (RFC1) in a cohort of adult patients with lymphoproliferative malignancies submitted to high-dose MTX followed by leucovorin rescue