Hepatobiliary Cystadenoma Revealed by a Jaundice: A Case Report

Introduction. Hepatobiliary cystadenomas are rare benign cystic tumors and have a potential for recurrence and malignant transformation. The diagnosis may be very difficult because of absence of typical imaging feature in some cases. Case Presentation. In this paper, the authors discuss a 57-year-old woman who presented a jaundice related to hepatobiliary cystadenoma. Biological and radiological examinations have led to surgery, and the diagnosis is made after a histological examination of surgical specimens. Conclusion. This observation illustrates a hepatobiliary cystadenoma revealed by jaundice. Histology examination contributed to diagnosis. The authors discussed the mechanisms of biliary obstruction and differential diagnoses through a review of the literature

Non-Redundant Combination of Hand-Crafted and Deep Learning Radiomics: Application to the Early Detection of Pancreatic Cancer

We address the problem of learning Deep Learning Radiomics (DLR) that are not redundant with Hand-Crafted Radiomics (HCR). To do so, we extract DLR features using a VAE while enforcing their independence with HCR features by minimizing their mutual information. The resulting DLR features can be combined with hand-crafted ones and leveraged by a classifier to predict early markers of cancer. We illustrate our method on four early markers of pancreatic cancer and validate it on a large independent test set. Our results highlight the value of combining non-redundant DLR and HCR features, as evidenced by an improvement in the Area Under the Curve compared to baseline methods that do not address redundancy or solely rely on HCR features.Comment: CaPTion workshop MICCAI 202

European Neuroendocrine Tumor Society 2023 guidance paper for functioning pancreatic neuroendocrine tumour syndromes.

This ENETS guidance paper aims to provide practical advice to clinicians for the diagnosis, treatment and follow-up of functioning syndromes in pancreatic neuroendocrine tumours (NET). A NET-associated functioning syndrome is defined by the presence of a clinical syndrome combined with biochemical evidence of inappropriately elevated hormonal levels. Different hormonal syndromes can be encountered in pancreatic NET patients, including insulinoma, gastrinoma as well as the rare glucagonoma, VIPoma, ACTHoma, PTHrPoma, carcinoid syndrome, calcitoninoma, GHRHoma and somatostatinoma. The recommendations provided in this paper focus on the biochemical, genetic and imaging work-up as well as therapeutic management of the individual hormonal syndromes in well-differentiated, grade 1-3, functioning NET with the primary tumour originating in the pancreas, and for specific subtypes also in the duodenum

Proposal of early CT morphological criteria for response of liver metastases to systemic treatments in gastroenteropancreatic neuroendocrine tumors:Alternatives to RECIST

RECIST 1.1 criteria are commonly used with computed tomography (CT) to evaluate the efficacy of systemic treatments in patients with neuroendocrine tumors (NETs) and liver metastases (LMs), but their relevance is questioned in this setting. We aimed to explore alternative criteria using different numbers of measured LMs and thresholds of size and density variation. We retrospectively studied patients with advanced pancreatic or small intestine NETs with LMs, treated with systemic treatment in the first-and/or second-line, without early progression, in 14 European expert centers. We compared time to treatment failure (TTF) between responders and non-responders according to various criteria defined by 0%, 10%, 20% or 30% decrease in the sum of LM size, and/or by 10%, 15% or 20% decrease in LM density, measured on two, three or five LMs, on baseline (≤1 month before treatment initiation) and first revaluation (≤6 months) contrast-enhanced CT scans. Multivariable Cox proportional hazard models were performed to adjust the association between response criteria and TTF on prognostic factors. We included 129 systemic treatments (long-acting somatostatin analogs 41.9%, chemotherapy 26.4%, targeted therapies 31.8%), administered as first-line (53.5%) or second-line therapies (46.5%) in 91 patients. A decrease ≥10% in the size of three LMs was the response criterion that best predicted prolonged TTF, with significance at multivariable analysis (HR 1.90; 95% CI: 1.06–3.40; p =.03). Conversely, response defined by RECIST 1.1 did not predict prolonged TTF (p =.91), and neither did criteria based on changes in LM density. A ≥10% decrease in size of three LMs could be a more clinically relevant criterion than the current 30% threshold utilized by RECIST 1.1 for the evaluation of treatment efficacy in patients with advanced NETs. Its implementation in clinical trials is mandatory for prospective validation. Criteria based on changes in LM density were not predictive of treatment efficacy. Clinical Trial Registration: Registered at CNIL-CERB, Assistance publique hopitaux de Paris as “E-NETNET-L-E-CT” July 2018. No number was assigned. Approved by the Medical Ethics Review Board of University Medical Center Groningen.</p

Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids

This is an expert consensus from the European Neuroendocrine Tumor Society recommending best practice for the management of pulmonary neuroendocrine tumors including typical and atypical carcinoids. It emphasizes the latest discussion on nomenclature, advances and utility of new diagnostic techniques as well as the limited evidence and difficulties in determining the optimal therapeutic strateg

Résécabilité et aspect morphologique des tumeurs intracanalaires papillaires et mucineuses du pancréas (corrélation tomodensitométrique, chirurgicale et anatomopathologique à propos de 61 patients)

PARIS-BIUM (751062103) / SudocCentre Technique Livre Ens. Sup. (774682301) / SudocSudocFranceF

Maladie de Caroli, Aspect morphologique et topographique des anomalies biliaires, étudiées par IRM et cholangiographie (A propos de 10 cas)

1) But : Etude morphologique et topographique des anomalies biliaires en IRM et cholangiographie. 2) Matériel et méthodes : Nous avons rétrospectivement analysé les images de 10 patients atteints de maladie de Caroli, diagnostiquée par l'imagerie IRM et/ou la chiolangiographie. Dans chacune des formes non héréditaire et héréditaire, a été recherchée une éventuelle prédominance soit d'un type morphologique des dilatations (kystiques ou tubulaires) soit de leur topographie par secteur (haut, bas, lobe droit, lobe gauche, antérieur, postérieur) 3) Résultats : Dix cas de maladie de Caroli ont eu une IRM et/ou une cholangiographie (4 non héréditaires et 6 héréditaires). Dans les formes non héréditaires les dilatations étaient moins nombreuses et plutôt tubulaires. Dans les formes héréditaires les dilatations étaient plus nombreuses et plus souvent kystiques. La majorité des dilalations biliaires des patients porteurs d'une maladie héréditaire ou non héréditaire prédominent dans le secteur antérieur du foie. 4) Conclusion : Le faible nombre de dilatations et leur morphologie plutôt tubulaire serait suggestive de la forme non héréditaire. L'ensemble des dilatations prédomine dans le secteur antérieur.PARIS7-Villemin (751102101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Apport du scanner dans l évaluation des facteurs prédictifs d une résection R1 au cours des duodénopancréatectomies céphaliques pour adénocarcinome du pancréas

PARIS7-Xavier Bichat (751182101) / SudocSudocFranceF

The Global Reading Room: Follow-Up of a Pancreatic Cyst

No abstract availabl