Le mariage de l’abstention et de la sincérité du scrutin : Une union … prudente et à trois !

Peut-on annuler une élection en cas d’une abstention importante ? Cette question a été ouverte par le Conseil constitutionnel dans sa décision QPC du 17 juin 2020 M. Daniel D. A l’issue des élections municipales de 2020, les requérants se sont largement emparés de ce moyen de droit sans pour autant obtenir dans la plupart des cas satisfaction. Le juge électoral a en effet soit considéré que ceux-ci n’invoquaient « aucune autre circonstance relative au déroulement de la campagne ou du scrutin dans la commune (…) qui montrerait en particulier, qu’il aurait été porté atteinte au libre exercice du droit de vote ou à l’égalité entre candidats » , soit apprécié de manière stricte lesdites circonstances de l’espèce. Une telle appréciation repose ainsi de manière invariable sur l’exigence d’un certain niveau d’abstention et d’un faible écart de voix (I). Après des positions variables adoptées par les juges électoraux du fond, il est désormais acquis que le mariage entre abstention et sincérité du scrutin est en fait une union à trois en supposant un dernier élément constitué par l’existence d’irrégularités observées pendant le scrutin (II)

Le mariage de l’abstention et de la sincérité du scrutin : Une union … prudente et à trois !

Peut-on annuler une élection en cas d’une abstention importante ? Cette question a été ouverte par le Conseil constitutionnel dans sa décision QPC du 17 juin 2020 M. Daniel D. A l’issue des élections municipales de 2020, les requérants se sont largement emparés de ce moyen de droit sans pour autant obtenir dans la plupart des cas satisfaction. Le juge électoral a en effet soit considéré que ceux-ci n’invoquaient « aucune autre circonstance relative au déroulement de la campagne ou du scrutin dans la commune (…) qui montrerait en particulier, qu’il aurait été porté atteinte au libre exercice du droit de vote ou à l’égalité entre candidats » , soit apprécié de manière stricte lesdites circonstances de l’espèce. Une telle appréciation repose ainsi de manière invariable sur l’exigence d’un certain niveau d’abstention et d’un faible écart de voix (I). Après des positions variables adoptées par les juges électoraux du fond, il est désormais acquis que le mariage entre abstention et sincérité du scrutin est en fait une union à trois en supposant un dernier élément constitué par l’existence d’irrégularités observées pendant le scrutin (II)

Les compétences transversales, une nouvelle « clé » pour l’insertion ? Enjeux et effets pour les acteurs

Rendre compte de la manière dont les acteurs, professionnels et jeunes adultes en parcours d’insertion, se saisissent et donnent sens à la notion de compétence transversale constitue l’objet de cette contribution. Après avoir situé le propos, en présentant la recherche (Ludo Ergo Sum) et son objet d’étude : le dispositif sociotechnique et vidéo-ludique (Skillpass), expérimenté en région Hauts-de-France au sein de différents dispositifs d’insertion socioprofessionnelle, les auteures développent les principales incidences repérées des usages de ce dispositif sur : les pratiques d’accompagnement mises en œuvre, les représentations des intervenants et les usages pédagogiques et professionnels qu’ils font de cette notion. Elles se centrent ensuite sur le regard porté sur la compétence transversale par les jeunes adultes faiblement qualifiés / scolarisés auxquels s’adresse le dispositif considéré : quel sens attribuent-ils au travail réalisé ? Quels apports en dégagent-ils en termes de réflexivité et dans l’optique de leur insertion ? S’appuyant sur les données d’enquête, cet article vise à caractériser la manière dont les acteurs se saisissent, résistent ou s’accommodent du « passage obligé » par la compétence transversale comme condition d’accès à l’emploi.The object of this contribution is to report on how the stakeholders involved in employment access programmes - professionals and young adults - take possession of and give meaning to the concept of transferable skills. After defining the aim of this paper, by presenting the research (Ludo Ergo Sum) and its object i.e. the sociotechnical videogaming training programme (Skillpass) experimented in different social and professional integration programmes in the Hauts-de-France region, the authors develop the design’s main impacts identified on the support practices implemented, the practitioners’ representations, and their educational and professional uses of this notion. The authors then focus on the view taken on transferable skills by poorly qualified/educated young adults, whom the training programme addresses: what meaning do they give to the work accomplished? What benefits do they gain in terms of reflexivity and integration? All the elements presented in this paper, resulting from the enquiry carried out as part of this research, aim at shedding light on how the stakeholders take possession of, resist or make the best of the requirement for transferable skills, prerequisites to employment access

A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing

Purpose Within the Solve-RD project (https://solve-rd.eu/), the European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies aimed to investigate whether a reanalysis of exomes from unsolved cases based on ClinVar annotations could establish additional diagnoses. We present the results of the “ClinVar low-hanging fruit” reanalysis, reasons for the failure of previous analyses, and lessons learned. Methods Data from the first 3576 exomes (1522 probands and 2054 relatives) collected from European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies was reanalyzed by the Solve-RD consortium by evaluating for the presence of single-nucleotide variant, and small insertions and deletions already reported as (likely) pathogenic in ClinVar. Variants were filtered according to frequency, genotype, and mode of inheritance and reinterpreted. Results We identified causal variants in 59 cases (3.9%), 50 of them also raised by other approaches and 9 leading to new diagnoses, highlighting interpretation challenges: variants in genes not known to be involved in human disease at the time of the first analysis, misleading genotypes, or variants undetected by local pipelines (variants in off-target regions, low quality filters, low allelic balance, or high frequency). Conclusion The “ClinVar low-hanging fruit” analysis represents an effective, fast, and easy approach to recover causal variants from exome sequencing data, herewith contributing to the reduction of the diagnostic deadlock

Enthalpies de formation des alliages liquides bismuth-étain-gallium à 723 k. Choix d’une représentation analytique des grandeurs d’excès intégrales et partielles de mélange

With a calorimeter at 723 K, we have determined the enthalpies of formation of some ternary liquid alloys which consist of bismuth-gallium-tin. We have compared our experimental results with those estimated according to excess functions of mixture and we have found that enthalpies of mixture are satisfactory represented by proposed equation. Based on these results, we give an analytical representation of partial mixing enthalpies of this ternary liquid system

Thermal assessment of internal shutters and window film applied to traditional single glazed sash and case windows

This report describes the work conducted by the Scottish Energy Centre (SEC) at Edinburgh Napier University for the National Trust of Scotland, measuring the thermal transmittance (U-value), for two types of glazing insulation: shutters and film. The objective was to determine the thermal insulation benefit of these measures when applied to an existing single glazed sash and case window. The building selected for the study is a detached 18th century cottage, Wee Causeway, located in Culross. It is a dwelling of traditional construction (solid stone wall) where some energy efficiency refurbishment works were completed in 2012 (wall and ceiling insulation). In the summer of 2013, glazing film, designed to improve thermal performance, was installed on all rear windows of the building, except the bathroom window. The textured translucent glass of the bathroom window proved unsuitable for the application of the glazing film. Thermally insulated timber shutters were applied to the interior side of the front facing window openings. The heat transfer through the bathroom glass and a front window pane was subsequently measured to provide a reference benchmark, to compare with the improved windows. This report also analyses the effectiveness of improvements for upgrading traditional buildings, combining 2012 wall monitoring (Currie et al., 2013) and 2014 window testing. Using SAP software, the report presents several modelled thermal scenarios, which demonstrate the effectiveness of each intervention if applied in isolation. Each modelled scenario is presented in terms of energy efficiency rating (SAP), environmental impact score, and space heating requirements. The report concludes by combining the most thermally efficient materials for each element into one 'best case' model. In Section 2, the methodology which was used for the testing of U-values in-situ is explained. The two methods of improving U-values for the windows are detailed in Section 3. Section 4 develops the results monitored in Wee Causeway and presents the findings of IR thermography and airtightness tests. Section 5 provides a review of the wall and ceiling thermal measurements completed in 2013. Finally Sections 6 and 7 present comparative tables detailing retrofitting techniques, and thermal performance indicators for the solutions trialled at Wee Causeway

Thermal assessment of internal shutters and window film applied to traditional single glazed sash and case windows

This report describes the work conducted by the Scottish Energy Centre (SEC) at Edinburgh Napier University for the National Trust of Scotland, measuring the thermal transmittance (U-value), for two types of glazing insulation: shutters and film. The objective was to determine the thermal insulation benefit of these measures when applied to an existing single glazed sash and case window. The building selected for the study is a detached 18th century cottage, Wee Causeway, located in Culross. It is a dwelling of traditional construction (solid stone wall) where some energy efficiency refurbishment works were completed in 2012 (wall and ceiling insulation). In the summer of 2013, glazing film, designed to improve thermal performance, was installed on all rear windows of the building, except the bathroom window. The textured translucent glass of the bathroom window proved unsuitable for the application of the glazing film. Thermally insulated timber shutters were applied to the interior side of the front facing window openings. The heat transfer through the bathroom glass and a front window pane was subsequently measured to provide a reference benchmark, to compare with the improved windows. This report also analyses the effectiveness of improvements for upgrading traditional buildings, combining 2012 wall monitoring (Currie et al., 2013) and 2014 window testing. Using SAP software, the report presents several modelled thermal scenarios, which demonstrate the effectiveness of each intervention if applied in isolation. Each modelled scenario is presented in terms of energy efficiency rating (SAP), environmental impact score, and space heating requirements. The report concludes by combining the most thermally efficient materials for each element into one 'best case' model. In Section 2, the methodology which was used for the testing of U-values in-situ is explained. The two methods of improving U-values for the windows are detailed in Section 3. Section 4 develops the results monitored in Wee Causeway and presents the findings of IR thermography and airtightness tests. Section 5 provides a review of the wall and ceiling thermal measurements completed in 2013. Finally Sections 6 and 7 present comparative tables detailing retrofitting techniques, and thermal performance indicators for the solutions trialled at Wee Causeway

Effects of Carbidopa Premedication on 18F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis

Purpose: This study aimed to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of 18F-FDOPA PET in brain tumors. Methods: The study included 54 patients, 18 of whom received carbidopa, who underwent 18F-FDOPA PET for newly diagnosed gliomas. SUV-derived, 105 radiomics features and TTP dynamic parameters were extracted from volumes of interest in healthy brains and tumors. Simulation of the effects of carbidopa on time-activity curves were generated. Results: All static and TTP dynamic parameters were significantly higher in healthy brain regions of premedicated patients (ΔSUVmean = +53%, ΔTTP = +48%, p < 0.001). Furthermore, carbidopa impacted 81% of radiomics features, of which 92% correlated with SUVmean (absolute correlation coefficient ≥ 0.4). In tumors, premedication with carbidopa was an independent predictor of SUVmean (ΔSUVmean = +52%, p < 0.001) and TTP (ΔTTP = +24%, p = 0.025). All parameters were no longer significantly modified by carbidopa premedication when using ratios to healthy brain. Simulated data confirmed that carbidopa leads to higher tumor TTP values, corrected by the ratios. Conclusion: In 18F-FDOPA PET, carbidopa induces similarly higher SUV and TTP dynamic parameters and similarly impacts SUV-dependent radiomics in healthy brain and tumor regions, which is compensated for by correcting for the tumor-to-healthy-brain ratio. This is a significant advantage for multicentric study harmonization