21 research outputs found
Le mariage de lâabstention et de la sincĂ©ritĂ© du scrutin : Une union ⊠prudente et Ă trois !
Peut-on annuler une Ă©lection en cas dâune abstention importante ? Cette question a Ă©tĂ© ouverte par le Conseil constitutionnel dans sa dĂ©cision QPC du 17 juin 2020 M. Daniel D.
A lâissue des Ă©lections municipales de 2020, les requĂ©rants se sont largement emparĂ©s de ce moyen de droit sans pour autant obtenir dans la plupart des cas satisfaction. Le juge Ă©lectoral a en effet soit considĂ©rĂ© que ceux-ci nâinvoquaient « aucune autre circonstance relative au dĂ©roulement de la campagne ou du scrutin dans la commune (âŠ) qui montrerait en particulier, quâil aurait Ă©tĂ© portĂ© atteinte au libre exercice du droit de vote ou Ă lâĂ©galitĂ© entre candidats » , soit apprĂ©ciĂ© de maniĂšre stricte lesdites circonstances de lâespĂšce. Une telle apprĂ©ciation repose ainsi de maniĂšre invariable sur lâexigence dâun certain niveau dâabstention et dâun faible Ă©cart de voix (I). AprĂšs des positions variables adoptĂ©es par les juges Ă©lectoraux du fond, il est dĂ©sormais acquis que le mariage entre abstention et sincĂ©ritĂ© du scrutin est en fait une union Ă trois en supposant un dernier Ă©lĂ©ment constituĂ© par lâexistence dâirrĂ©gularitĂ©s observĂ©es pendant le scrutin (II)
Le mariage de lâabstention et de la sincĂ©ritĂ© du scrutin : Une union ⊠prudente et Ă trois !
Peut-on annuler une Ă©lection en cas dâune abstention importante ? Cette question a Ă©tĂ© ouverte par le Conseil constitutionnel dans sa dĂ©cision QPC du 17 juin 2020 M. Daniel D.
A lâissue des Ă©lections municipales de 2020, les requĂ©rants se sont largement emparĂ©s de ce moyen de droit sans pour autant obtenir dans la plupart des cas satisfaction. Le juge Ă©lectoral a en effet soit considĂ©rĂ© que ceux-ci nâinvoquaient « aucune autre circonstance relative au dĂ©roulement de la campagne ou du scrutin dans la commune (âŠ) qui montrerait en particulier, quâil aurait Ă©tĂ© portĂ© atteinte au libre exercice du droit de vote ou Ă lâĂ©galitĂ© entre candidats » , soit apprĂ©ciĂ© de maniĂšre stricte lesdites circonstances de lâespĂšce. Une telle apprĂ©ciation repose ainsi de maniĂšre invariable sur lâexigence dâun certain niveau dâabstention et dâun faible Ă©cart de voix (I). AprĂšs des positions variables adoptĂ©es par les juges Ă©lectoraux du fond, il est dĂ©sormais acquis que le mariage entre abstention et sincĂ©ritĂ© du scrutin est en fait une union Ă trois en supposant un dernier Ă©lĂ©ment constituĂ© par lâexistence dâirrĂ©gularitĂ©s observĂ©es pendant le scrutin (II)
Les compĂ©tences transversales, une nouvelle « clé » pour lâinsertion ? Enjeux et effets pour les acteurs
Rendre compte de la maniĂšre dont les acteurs, professionnels et jeunes adultes en parcours dâinsertion, se saisissent et donnent sens Ă la notion de compĂ©tence transversale constitue lâobjet de cette contribution. AprĂšs avoir situĂ© le propos, en prĂ©sentant la recherche (Ludo Ergo Sum) et son objet dâĂ©tude : le dispositif sociotechnique et vidĂ©o-ludique (Skillpass), expĂ©rimentĂ© en rĂ©gion Hauts-de-France au sein de diffĂ©rents dispositifs dâinsertion socioprofessionnelle, les auteures dĂ©veloppent les principales incidences repĂ©rĂ©es des usages de ce dispositif sur : les pratiques dâaccompagnement mises en Ćuvre, les reprĂ©sentations des intervenants et les usages pĂ©dagogiques et professionnels quâils font de cette notion. Elles se centrent ensuite sur le regard portĂ© sur la compĂ©tence transversale par les jeunes adultes faiblement qualifiĂ©s / scolarisĂ©s auxquels sâadresse le dispositif considĂ©rĂ©Â : quel sens attribuent-ils au travail rĂ©alisĂ©Â ? Quels apports en dĂ©gagent-ils en termes de rĂ©flexivitĂ© et dans lâoptique de leur insertion ? Sâappuyant sur les donnĂ©es dâenquĂȘte, cet article vise Ă caractĂ©riser la maniĂšre dont les acteurs se saisissent, rĂ©sistent ou sâaccommodent du « passage obligé » par la compĂ©tence transversale comme condition dâaccĂšs Ă lâemploi.The object of this contribution is to report on how the stakeholders involved in employment access programmes - professionals and young adults - take possession of and give meaning to the concept of transferable skills. After defining the aim of this paper, by presenting the research (Ludo Ergo Sum) and its object i.e. the sociotechnical videogaming training programme (Skillpass) experimented in different social and professional integration programmes in the Hauts-de-France region, the authors develop the designâs main impacts identified on the support practices implemented, the practitionersâ representations, and their educational and professional uses of this notion. The authors then focus on the view taken on transferable skills by poorly qualified/educated young adults, whom the training programme addresses: what meaning do they give to the work accomplished? What benefits do they gain in terms of reflexivity and integration? All the elements presented in this paper, resulting from the enquiry carried out as part of this research, aim at shedding light on how the stakeholders take possession of, resist or make the best of the requirement for transferable skills, prerequisites to employment access
A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing
Purpose
Within the Solve-RD project (https://solve-rd.eu/), the European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies aimed to investigate whether a reanalysis of exomes from unsolved cases based on ClinVar annotations could establish additional diagnoses. We present the results of the âClinVar low-hanging fruitâ reanalysis, reasons for the failure of previous analyses, and lessons learned.
Methods
Data from the first 3576 exomes (1522 probands and 2054 relatives) collected from European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies was reanalyzed by the Solve-RD consortium by evaluating for the presence of single-nucleotide variant, and small insertions and deletions already reported as (likely) pathogenic in ClinVar. Variants were filtered according to frequency, genotype, and mode of inheritance and reinterpreted.
Results
We identified causal variants in 59 cases (3.9%), 50 of them also raised by other approaches and 9 leading to new diagnoses, highlighting interpretation challenges: variants in genes not known to be involved in human disease at the time of the first analysis, misleading genotypes, or variants undetected by local pipelines (variants in off-target regions, low quality filters, low allelic balance, or high frequency).
Conclusion
The âClinVar low-hanging fruitâ analysis represents an effective, fast, and easy approach to recover causal variants from exome sequencing data, herewith contributing to the reduction of the diagnostic deadlock
Enthalpies de formation des alliages liquides bismuth-Ă©tain-gallium Ă 723 k. Choix dâune reprĂ©sentation analytique des grandeurs dâexcĂšs intĂ©grales et partielles de mĂ©lange
With a calorimeter at 723 K, we have determined the enthalpies of formation of some ternary liquid alloys which consist of bismuth-gallium-tin.
We have compared our experimental results with those estimated according to excess functions of mixture and we have found that enthalpies of mixture are satisfactory represented by proposed equation. Based on these results, we give an analytical representation of partial mixing enthalpies of this ternary liquid system
Thermal assessment of internal shutters and window film applied to traditional single glazed sash and case windows
This report describes the work conducted by the Scottish Energy Centre (SEC) at Edinburgh Napier University for the National Trust of Scotland, measuring the thermal transmittance (U-value), for two types of glazing insulation: shutters and film. The objective was to determine the thermal insulation benefit of these measures when applied to an existing single glazed sash and case window. The building selected for the study is a detached 18th century cottage, Wee Causeway, located in Culross. It is a dwelling of traditional construction (solid stone wall) where some energy efficiency refurbishment works were completed in 2012 (wall and ceiling insulation). In the summer of 2013, glazing film, designed to improve thermal performance, was installed on all rear windows of the building, except the bathroom window. The textured translucent glass of the bathroom window proved unsuitable for the application of the glazing film. Thermally insulated timber shutters were applied to the interior side of the front facing window openings. The heat transfer through the bathroom glass and a front window pane was subsequently measured to provide a reference benchmark, to compare with the improved windows. This report also analyses the effectiveness of improvements for upgrading traditional buildings, combining 2012 wall monitoring (Currie et al., 2013) and 2014 window testing. Using SAP software, the report presents several modelled thermal scenarios, which demonstrate the effectiveness of each intervention if applied in isolation. Each modelled scenario is presented in terms of energy efficiency rating (SAP), environmental impact score, and space heating requirements. The report concludes by combining the most thermally efficient materials for each element into one 'best case' model. In Section 2, the methodology which was used for the testing of U-values in-situ is explained. The two methods of improving U-values for the windows are detailed in Section 3. Section 4 develops the results monitored in Wee Causeway and presents the findings of IR thermography and airtightness tests. Section 5 provides a review of the wall and ceiling thermal measurements completed in 2013. Finally Sections 6 and 7 present comparative tables detailing retrofitting techniques, and thermal performance indicators for the solutions trialled at Wee Causeway
Thermal assessment of internal shutters and window film applied to traditional single glazed sash and case windows
This report describes the work conducted by the Scottish Energy Centre (SEC) at Edinburgh Napier University for the National Trust of Scotland, measuring the thermal transmittance (U-value), for two types of glazing insulation: shutters and film. The objective was to determine the thermal insulation benefit of these measures when applied to an existing single glazed sash and case window. The building selected for the study is a detached 18th century cottage, Wee Causeway, located in Culross. It is a dwelling of traditional construction (solid stone wall) where some energy efficiency refurbishment works were completed in 2012 (wall and ceiling insulation). In the summer of 2013, glazing film, designed to improve thermal performance, was installed on all rear windows of the building, except the bathroom window. The textured translucent glass of the bathroom window proved unsuitable for the application of the glazing film. Thermally insulated timber shutters were applied to the interior side of the front facing window openings. The heat transfer through the bathroom glass and a front window pane was subsequently measured to provide a reference benchmark, to compare with the improved windows. This report also analyses the effectiveness of improvements for upgrading traditional buildings, combining 2012 wall monitoring (Currie et al., 2013) and 2014 window testing. Using SAP software, the report presents several modelled thermal scenarios, which demonstrate the effectiveness of each intervention if applied in isolation. Each modelled scenario is presented in terms of energy efficiency rating (SAP), environmental impact score, and space heating requirements. The report concludes by combining the most thermally efficient materials for each element into one 'best case' model. In Section 2, the methodology which was used for the testing of U-values in-situ is explained. The two methods of improving U-values for the windows are detailed in Section 3. Section 4 develops the results monitored in Wee Causeway and presents the findings of IR thermography and airtightness tests. Section 5 provides a review of the wall and ceiling thermal measurements completed in 2013. Finally Sections 6 and 7 present comparative tables detailing retrofitting techniques, and thermal performance indicators for the solutions trialled at Wee Causeway
Effects of Carbidopa Premedication on 18F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis
Purpose: This study aimed to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of 18F-FDOPA PET in brain tumors. Methods: The study included 54 patients, 18 of whom received carbidopa, who underwent 18F-FDOPA PET for newly diagnosed gliomas. SUV-derived, 105 radiomics features and TTP dynamic parameters were extracted from volumes of interest in healthy brains and tumors. Simulation of the effects of carbidopa on time-activity curves were generated. Results: All static and TTP dynamic parameters were significantly higher in healthy brain regions of premedicated patients (ÎSUVmean = +53%, ÎTTP = +48%, p < 0.001). Furthermore, carbidopa impacted 81% of radiomics features, of which 92% correlated with SUVmean (absolute correlation coefficient â„ 0.4). In tumors, premedication with carbidopa was an independent predictor of SUVmean (ÎSUVmean = +52%, p < 0.001) and TTP (ÎTTP = +24%, p = 0.025). All parameters were no longer significantly modified by carbidopa premedication when using ratios to healthy brain. Simulated data confirmed that carbidopa leads to higher tumor TTP values, corrected by the ratios. Conclusion: In 18F-FDOPA PET, carbidopa induces similarly higher SUV and TTP dynamic parameters and similarly impacts SUV-dependent radiomics in healthy brain and tumor regions, which is compensated for by correcting for the tumor-to-healthy-brain ratio. This is a significant advantage for multicentric study harmonization