213 research outputs found
Sensorimotor learning in a Bayesian computational model of speech communication
International audienceAlthough sensorimotor exploration is a basic process within child development, clear views on the underlying computational processes remain challenging. We propose to compare eight algorithms for sensorimotor exploration, based on three components: " accommodation " performing a compromise between goal babbling and social guidance by a master, " local extrapolation " simulating local exploration of the sensorimotor space to achieve motor generalizations and " idiosyncratic babbling " which favors already explored motor commands when they are efficient. We will show that a mix of these three components offers a good compromise enabling efficient learning while reducing exploration as much as possible
Modeling the concurrent development of speech perception and production in a Bayesian framework: COSMO, a Bayesian computational model of speech communication: Assessing the role of sensory vs. motor knowledge in speech perception
International audienceIt is now widely accepted that there is a functional relationship between the speech perception and production systems in the human brain. However, the precise mechanisms and role of this relationship still remain debated. The question of invariance and robustness in categorization are set at the center of the debate: how is stable information extracted from the variable sensory input in order to achieve speech comprehension? In this context, auditory (resp. motor, perceptuo-motor) theories propose that speech is categorized thanks to auditory (resp. motor, perceptuo-motor) processes. However, experimental evidence is still scarce and does not allow to clearly distinguish between the current theories and determine whether invariance in speech perception is of an auditory or motor type. This is why we developed COSMO, a Bayesian model comparing sensory and motor processes in the form of probability distributions which enable both theoretical developments and quantitative simulations. A first significant result in COSMO is an indistinguishability theorem: it is only by simulations of adverse conditions or partial learning that the specificity of sensory vs. motor processing can emerge and provide a basis for evaluation of the specific role of each sub-system. We present the COSMO model, and how its sensory and motor sub-systems are learned, then we describe simulations exploring the way these sub-systems differ during speech categorization. We discuss the experimental results in the light of a “narrowband vs. wideband” interpretation: the sensory sub-system is more precisely tuned to the frequently learned sensory input and hence more efficient in recognizing these inputs, providing a “narrowband” system. Conversely, the motor sub-system is less accurate to recognize learned sensory inputs but it has better generalization properties, making it more robust to unexpected variability which would provide it with “wideband” characteristics
Assessing Idiosyncrasies in a Bayesian Model of Speech Communication
International audienceAlthough speakers of one specific language share the same phoneme representations, their productions can differ. We propose to investigate the development of these differences in production , called idiosyncrasies, by using a Bayesian model of communication. Supposing that idiosyncrasies appear during the development of the motor system, we present two versions of the motor learning phase, both based on the guidance of an agent master: " a repetition model " where agents try to imitate the sounds produced by the master and " a communication model " where agents try to replicate the phonemes produced by the master. Our experimental results show that only the " communication model " provides production idiosyncrasies, suggesting that idiosyncrasies are a natural output of a motor learning process based on a communicative goal
Eating behavior traits and sleep as determinants of weight loss in overweight and obese adults
Objective: To examine the associations between eating behavior traits and weight loss according to sleep quality and duration in adults enrolled in common weight-loss interventions.
Methods: Participants included overweight and obese men and women (n=150) (mean±s.d. age, 38.8±8.6 years; mean±s.d. body mass index (BMI), 33.3±3.5 kg m−2) who were subjected to a dietary intervention over a period of 12–16 weeks. Anthropometric measurements, eating behavior traits (Three-Factor Eating Questionnaire), sleep quality (total Pittsburgh Sleep Quality Index (PSQI) score) and sleep duration (hours per night, self-reported from the PSQI) were assessed at both baseline and post intervention. Linear regression analysis was used to quantify the relationships between eating behavior traits and changes in anthropometric markers for all subjects and by sleep categories (short sleep: <7 h per night vs recommended sleep: greater than or equal to7 h per night; poor sleep quality: greater than or equal to5 PSQI score vs good sleep quality: <5 PSQI score). We adjusted for age, sex and baseline BMI in analyses.
Results: Baseline eating behavior traits were modest predictors of weight-loss success, but they were all significantly associated with their changes over the weight-loss intervention (P<0.01). The diet intervention induced significant changes in eating behavior traits and even more for those having a non-favorable eating behavior profile at baseline. We observed that changes in flexible control and strategic dieting behavior were constantly negatively associated with changes in body weight and fat mass (P<0.05) for recommended duration sleepers. The change in situational susceptibility to disinhibition was positively associated with the change in fat mass and body weight for those having healthy sleeping habits (P<0.05). For poor quality sleepers, the change in avoidance of fattening foods was negatively associated with changes in adiposity (P<0.05).
Conclusion: Eating behavior traits and sleep may act together to influence the outcome of weight-loss programs
Sensorimotor learning in a Bayesian computational model of speech communication
International audienceAlthough sensorimotor exploration is a basic process within child development, clear views on the underlying computational processes remain challenging. We propose to compare eight algorithms for sensorimotor exploration, based on three components: " accommodation " performing a compromise between goal babbling and social guidance by a master, " local extrapolation " simulating local exploration of the sensorimotor space to achieve motor generalizations and " idiosyncratic babbling " which favors already explored motor commands when they are efficient. We will show that a mix of these three components offers a good compromise enabling efficient learning while reducing exploration as much as possible
Phonology in the mirror: Comment on "Towards a Computational Comparative Neuroprimatology: Framing the language-ready brain" by Michael A. Arbib
International audienceThe contribution by M.A. Arbib over the years and as it appears summarized and conceptualized in this paper is admirable, extremely impressive, and very convincing in many aspects. A key value of this work is that it systematically attempts to introduce formal conceptualization and modeling in the reasoning about facts and interpretations
‘… a huge monster that should be feared and not done’: lessons learned in sexuality education classes in South Africa
Research has foregrounded the way in which heterosexual practices for many young people are not infrequently bound up with violence and unequal transactional power relations. The Life Orientation sexuality education curriculum in South African schools has been viewed as a potentially valuable space to work with young people on issues of reproductive health, gender and sexual norms and relations. Yet, research has illustrated that such work may not only be failing to impact on more equitable sexual practices between young men and women, but may also serve to reproduce the very discourses and practices that the work aims to challenge. Cultures of violence in youth sexuality are closely connected to prevailing gender norms and practices which, for example, render women as passive victims who are incapable of exercising sexual agency and men as inherently sexually predatory. This paper analyses the talk of Grade 10 learners in nine diverse schools in two South African provinces, the Eastern Cape and the Western Cape, to highlight what ‘lessons’ these young people seem to be learning about sexuality in Life Orientation classes. We find that these lessons foreground cautionary, negative and punitive messages, which reinforce, rather than challenge, normative gender roles. ‘Scare’ messages of danger, damage and disease give rise to presumptions of gendered responsibility for risk and the requirement of female restraint in the face of the assertion of masculine desire and predation. We conclude that the role which sexuality education could play in enabling young women in particular to more successfully negotiate their sexual relationships to serve their own needs, reproductive health and safety, is undermined by regulatory messages directed at controlling young people, and young women in particular – and that instead, young people’s sexual agency has to be acknowledged in any processes of change aimed at gender equality, anti-violence, health and well-being
‘… a huge monster that should be feared and not done’: lessons learned in sexuality education classes in South Africa
Research has foregrounded the way in which heterosexual practices for many young people are not infrequently bound up with violence and unequal transactional power relations. The Life Orientation sexuality education curriculum in South African schools has been viewed as a potentially valuable space to work with young people on issues of reproductive health, gender and sexual norms and relations. Yet, research has illustrated that such work may not only be failing to impact on more equitable sexual practices between young men and women, but may also serve to reproduce the very discourses and practices that the work aims to challenge. Cultures of violence in youth sexuality are closely connected to prevailing gender norms and practices which, for example, render women as passive victims who are incapable of exercising sexual agency and men as inherently sexually predatory. This paper analyses the talk of Grade 10 learners in nine diverse schools in two South African provinces, the Eastern Cape and the Western Cape, to highlight what ‘lessons’ these young people seem to be learning about sexuality in Life Orientation classes. We find that these lessons foreground cautionary, negative and punitive messages, which reinforce, rather than challenge, normative gender roles. ‘Scare’ messages of danger, damage and disease give rise to presumptions of gendered responsibility for risk and the requirement of female restraint in the face of the assertion of masculine desire and predation. We conclude that the role which sexuality education could play in enabling young women in particular to more successfully negotiate their sexual relationships to serve their own needs, reproductive health and safety, is undermined by regulatory messages directed at controlling young people, and young women in particular – and that instead, young people’s sexual agency has to be acknowledged in any processes of change aimed at gender equality, anti-violence, health and well-being
Membrane estrogen receptor-α contributes to female protection against high-fat diet-induced metabolic disorders
BackgroundEstrogen Receptor α (ERα) is a significant modulator of energy balance and lipid/glucose metabolisms. Beyond the classical nuclear actions of the receptor, rapid activation of intracellular signaling pathways is mediated by a sub-fraction of ERα localized to the plasma membrane, known as Membrane Initiated Steroid Signaling (MISS). However, whether membrane ERα is involved in the protective metabolic actions of endogenous estrogens in conditions of nutritional challenge, and thus contributes to sex differences in the susceptibility to metabolic diseases, remains to be clarified.MethodsMale and female C451A-ERα mice, harboring a point mutation which results in the abolition of membrane localization and MISS-related effects of the receptor, and their wild-type littermates (WT-ERα) were maintained on a normal chow diet (NCD) or fed a high-fat diet (HFD). Body weight gain, body composition and glucose tolerance were monitored. Insulin sensitivity and energy balance regulation were further investigated in HFD-fed female mice.ResultsC451A-ERα genotype had no influence on body weight gain, adipose tissue accumulation and glucose tolerance in NCD-fed mice of both sexes followed up to 7 months of age, nor male mice fed a HFD for 12 weeks. In contrast, compared to WT-ERα littermates, HFD-fed C451A-ERα female mice exhibited: 1) accelerated fat mass accumulation, liver steatosis and impaired glucose tolerance; 2) whole-body insulin resistance, assessed by hyperinsulinemic-euglycemic clamps, and altered insulin-induced signaling in skeletal muscle and liver; 3) significant decrease in energy expenditure associated with histological and functional abnormalities of brown adipose tissue and a defect in thermogenesis regulation in response to cold exposure.ConclusionBesides the well-characterized role of ERα nuclear actions, membrane-initiated ERα extra-nuclear signaling contributes to female, but not to male, protection against HFD-induced obesity and associated metabolic disorders in mouse
Tuberculosis in Pediatric Antiretroviral Therapy Programs in Low- and Middle-Income Countries: Diagnosis and Screening Practices
Background The global burden of childhood tuberculosis (TB) is estimated to be 0.5 million new cases per year. Human immunodeficiency virus (HIV)-infected children are at high risk for TB. Diagnosis of TB in HIV-infected children remains a major challenge. Methods We describe TB diagnosis and screening practices of pediatric antiretroviral treatment (ART) programs in Africa, Asia, the Caribbean, and Central and South America. We used web-based questionnaires to collect data on ART programs and patients seen from March to July 2012. Forty-three ART programs treating children in 23 countries participated in the study. Results Sputum microscopy and chest Radiograph were available at all programs, mycobacterial culture in 40 (93%) sites, gastric aspiration in 27 (63%), induced sputum in 23 (54%), and Xpert MTB/RIF in 16 (37%) sites. Screening practices to exclude active TB before starting ART included contact history in 41 sites (84%), symptom screening in 38 (88%), and chest Radiograph in 34 sites (79%). The use of diagnostic tools was examined among 146 children diagnosed with TB during the study period. Chest Radiograph was used in 125 (86%) children, sputum microscopy in 76 (52%), induced sputum microscopy in 38 (26%), gastric aspirate microscopy in 35 (24%), culture in 25 (17%), and Xpert MTB/RIF in 11 (8%) children. Conclusions Induced sputum and Xpert MTB/RIF were infrequently available to diagnose childhood TB, and screening was largely based on symptom identification. There is an urgent need to improve the capacity of ART programs in low- and middle-income countries to exclude and diagnose TB in HIV-infected childre
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