Adjunctive Immunotherapy With Polyclonal Ig-M Enriched Immunoglobulins for Septic Shock: From Bench to Bedside. The Rationale for a Personalized Treatment Protocol

Septic shock still has a high mortality rate which has not hinted at decreasing in recent years. Unfortunately, randomized trials failed mainly because the septic patient was considered as a homogeneous entity. All this creates a sort of therapeutic impotence in everyday clinical practice in treating patients with septic shock. The need to customize therapy on each patient with sepsis has now become an established necessity. In this scenario, adjuvant therapies can help if interpreted as modulators of the immune system. Indeed, the host’s immune response differs from patient to patient based on the virulence of the pathogen, comorbidity, infection site, and prolonged hospitalization. In this review, we summarize the rationale for using immunoglobulins as an adjunctive treatment. Furthermore, we would like to suggest a possible protocol to personalize treatment in the different clinical scenarios of the host’s response to serious infectious events

Italia Roman\ued vol. VI Le migrazioni dei rom romeni in Italia

Italia roman\ued non vuole presentare donne e uomini sui quali posare uno sguardo distanziatore ed esotico, n\ue9 vuole contribuire a mantenere e ad aumentare la distanza e l\u2019esotismo. Italia roman\ued vuole parlare di persone che sono prima di tutto, in Italia, dei cittadini italiani o dei cittadini stranieri.Italia roman\ued non parla, quindi, di \u201cZingari italiani\u201d e \u201cZingari stranieri\u201d, ma di italiani e stranieri che sono chiamati Zingari con un processo di \u201ctenuta a distanza\u201d che si \ue8 storicamente costituito e che \ue8 oggi socialmente e politicamente mantenuto in vita.Italia roman\ued parla di queste persone giuridicamente tenute a distanza perch\ue9 culturalmente diverse per convincere il lettore che ci\uf2 \ue8 un\u2019ingiustizia: un\u2019altra

Comparison of point shear wave elastography and transient elastography in the evaluation of patients with NAFLD

Purpose To compare point shear wave elastography (pSWE, ElastPQ (R)) and transient elastography (TE) with Liver Biopsy in order to evaluate fibrosis stage in non-alcoholic fatty liver disease (NAFLD). Methods Our prospective study from September 2017 to October 2020 included 50 consecutively enrolled patients with NAFLD (52.2 +/- 13.0 years, 32 male). All patients underwent clinical evaluation, B-mode ultrasound, pSWE, TE and liver biopsy in a single evaluation. The clinical, laboratory and liver biopsy data were compared with liver stiffness (LS) measurement obtained with pSWE and TE. TE and pSWE diagnostic accuracy for the diagnosis of the different fibrosis stages were evaluated using the area under receiver operating characteristic curve (AUROC). Results Only fibrosis stage was independently associated with TE and pSWE. The median liver stiffness measurement for fibrosis stages F0, F1, F2, F3, and F4 using TE was 4.8 (4.7-6.1) kPa, 5.5 (4.4-7.3) kPa, 7.7 (6.1-9.1) kPa, 9.9 (8.8-13.8) kPa, and 20.2 kPa, respectively. The corresponding median liver stiffness measurement using pSWE was 4.2 (4.0-4.8) kPa, 4.7 (4.2-5.8) kPa, 5.1 (4.1-6.9) kPa, 8.5 (5.2-13.3), and 15.1 kPa, respectively. The AUROC of TE for diagnosis of fibrosis stage F1, >= F2, >= F3, and F4 were 0.795, 0.867, 0.927, and 0.990, respectively. The corresponding AUROC of pSWE was 0.717, 0.733, 0.908, and 1.000, respectively. No association was observed with other histological parameters. Conclusion TE was significantly better than pSWE for the diagnosis of fibrosis stage >= F2. No statistically significant differences were found between TE and pSWE AUROC of fibrosis stage >= F1, >= F3, and F4

Report on the Follow Up Survey from the project "The immigration of Romanian Roma to Western Europe: causes, effects and future engagement strategies - MigRom"

Results of the Follow Up Survey carried out by the Italian team of the European project "The immigration of Romanian Roma to Western Europe: Causes, effects, and future engagement strategies - MigRom", a project funded by the European Union's Seventh Framework Programme (Call FP7-SSH-2012-2: "Dealing with diversity and cohesion: the case of the Roma in the European Union"; Grant Agreement n. 319901)

Endocytosis of Nanomedicines: The Case of Glycopeptide Engineered PLGA Nanoparticles

The success of nanomedicine as a new strategy for drug delivery and targeting prompted the interest in developing approaches toward basic and clinical neuroscience. Despite enormous advances on brain research, central nervous system (CNS) disorders remain the world’s leading cause of disability, in part due to the inability of the majority of drugs to reach the brain parenchyma. Many attempts to use nanomedicines as CNS drug delivery systems (DDS) were made; among the various non-invasive approaches, nanoparticulate carriers and, particularly, polymeric nanoparticles (NPs) seem to be the most interesting strategies. In particular, the ability of poly-lactide-co-glycolide NPs (PLGA-NPs) specifically engineered with a glycopeptide (g7), conferring to NPs’ ability to cross the blood brain barrier (BBB) in rodents at a concentration of up to 10% of the injected dose, was demonstrated in previous studies using different routes of administrations. Most of the evidence on NP uptake mechanisms reported in the literature about intracellular pathways and processes of cell entry is based on in vitro studies. Therefore, beside the particular attention devoted to increasing the knowledge of the rate of in vivo BBB crossing of nanocarriers, the subsequent exocytosis in the brain compartments, their fate and trafficking in the brain surely represent major topics in this field

Abitare. Estrazione di rendita e spazio urbano

10noPer comprendere le radici dell’emergenza abitativa è essenziale innanzitutto capire che la questione non riguarda la casa in quanto tale, ma lo spazio urbano. Ancora oggi, benché in circostanze mutate, vale l’insegnamento dei classici: «è la rendita del suolo e non la casa ciò che costituisce propriamente l’oggetto principale della speculazione edilizia nelle città in rapido sviluppo» (Marx 1 894, vol. III, Parte VI, cap. 46). Le difficoltà abitative sono legate all’andamento dei costi di acquisto e locazione delle case, ma questi costi, assai più che al valore dell’abitazione in sé, sono legati al valore del suolo, il quale è a sua volta dipendente dalla posizione nello spazio urbano. In definitiva, la questione abitativa non può essere compresa, né tantomeno affrontata, senza prendere in considerazione il modo in cui lo spazio urbano è utilizzato, posseduto, governato (Bricocoli e Salento, 2020; Arbaci et al. 2021 ). Nei centri urbani più attrattivi, la difficoltà di accesso al bene-casa è connessa al costo di acquisto e di locazione degli alloggi.reservedmixedMassimo Bricocoli; Luca Calafati; Ester Cois; Lorenzo De Vidovich; Marianna Filandri; Marco Peverini; Angelo Salento; Marta Tonetta; Simone Tosi; Federica ViganòBricocoli, Massimo; Calafati, Luca; Cois, Ester; DE VIDOVICH, LORENZO RAIMONDO; Filandri, Marianna; Peverini, Marco; Salento, Angelo; Tonetta, Marta; Tosi, Simone; Viganò, Federic

Women in Nineteenth-Century Russia

Russian women of the nineteenth century are often thought of in their literary incarnations as the heroines of novels such as Anna Karenina and War and Peace. But their real counterparts are now becoming better understood as active contributors to Russia’s varied cultural landscape. This collection of essays examines the lives of women across Russia – from wealthy noblewomen in St Petersburg to desperately poor peasants in Siberia – discussing their interaction with the Church and the law, and their rich contribution to music, art, literature and theatre. It shows how women struggled for greater autonomy and, both individually and collectively, developed a dynamic but often overlooked presence in Russia's culture and society during the long nineteenth century (1800-1917). Women in Nineteenth-Century Russia provides invaluable reading for anyone interested in Russian history, nineteenth-century culture and gender studies.Wendy Rosslyn is Emeritus Professor of Russian Literature at the University of Nottingham, UK. Her research on Russian women includes Anna Bunina (1774-1829) and the Origins of Women’s Poetry in Russia (1997), Feats of Agreeable Usefulness: Translations by Russian Women Writers 1763-1825 (2000) and Deeds not Words: The Origins of Female Philantropy in the Russian Empire (2007).Alessandra Tosi is a Fellow at Clare Hall, Cambridge. Her publications include Waiting for Pushkin: Russian Fiction in the Reign of Alexander I (1801-1825) (2006), A. M. Belozel’skii-Belozerskii i ego filosofskoe nasledie (with T. V. Artem’eva et al.) and Women in Russian Culture and Society, 1700-1825 (2007), edited with Wendy Rosslyn

Women in Nineteenth-Century Russia

Russian women of the nineteenth century are often thought of in their literary incarnations as the heroines of novels such as Anna Karenina and War and Peace. But their real counterparts are now becoming better understood as active contributors to Russia’s varied cultural landscape. This collection of essays examines the lives of women across Russia – from wealthy noblewomen in St Petersburg to desperately poor peasants in Siberia – discussing their interaction with the Church and the law, and their rich contribution to music, art, literature and theatre. It shows how women struggled for greater autonomy and, both individually and collectively, developed a dynamic but often overlooked presence in Russia's culture and society during the long nineteenth century (1800-1917). Women in Nineteenth-Century Russia provides invaluable reading for anyone interested in Russian history, nineteenth-century culture and gender studies.Wendy Rosslyn is Emeritus Professor of Russian Literature at the University of Nottingham, UK. Her research on Russian women includes Anna Bunina (1774-1829) and the Origins of Women’s Poetry in Russia (1997), Feats of Agreeable Usefulness: Translations by Russian Women Writers 1763-1825 (2000) and Deeds not Words: The Origins of Female Philantropy in the Russian Empire (2007).Alessandra Tosi is a Fellow at Clare Hall, Cambridge. Her publications include Waiting for Pushkin: Russian Fiction in the Reign of Alexander I (1801-1825) (2006), A. M. Belozel’skii-Belozerskii i ego filosofskoe nasledie (with T. V. Artem’eva et al.) and Women in Russian Culture and Society, 1700-1825 (2007), edited with Wendy Rosslyn