Implications of Vitamin D Status for Children’s Bone Health: A Data Mining Analyses of Observational Studies

Objective: To investigate associations/correlations between bone alterations and vitamin D status in children through data mining analyses based on observational studies. Material and Methods: Searches in PubMed, Scopus, Web of Science, and Embase databases were performed to recover studies, published until October 2022, with healthy children, which investigated the vitamin D status, related or not to undesirable bone alterations linked to bone quality (bone mineral density and bone mineral content), fracture or anthropometry. Country, study design, area of expertise (medicine, nutrition, dentistry, others), bone outcome, 25-hydroxyvitamin D data (serum or intake levels), the exams for bone diagnosis, and the results were analyzed in the VantagePointTM software. Results: Of 20,583 studies, 27 were included. The USA (n=9; 33.3%) had the highest number of publications. Cross-sectional (n=11; 40.7%), case-control (n=9; 33.3%), and cohort studies (n=7; 25.9%) contemplated the medicine and nutritional areas without any study in dentistry. Studies about bone quality (n=21; 77.8%), analyzed through dual-energy X-ray absorptiometry (DXA; n=14; 51.8%), with association (n=16; 59.2%) between the low serum levels of 25-hydroxyvitamin D and undesirable bone alterations (n=14; 51.8%) were the most prevalent. Conclusion: Most studies were conducted in the medical area and showed an association between low bone quality and low levels of 25-hydroxyvitamin D, verified through DXA

Red propolis hydroalcoholic extract inhibits the formation of Candida albicans biofilms on denture surface

To evaluate the antifungal activity of the red propolis hydroalcoholic extract (RPHE) against Candida albicans biofilms. The minimum inhibitory and fungicidal concentrations (MIC and MFC) of the RPHE were determined by the microdilution technique. C. albicans biofilms were formed on the surface of resin specimens preconditioned with artificial saliva (1h). The specimens (N=48) were equally divided according to the four solutions used for anti-biofilm evaluation (n=12 per group). After overnight incubation, biofilms were daily exposed (2x/day for 15 min) along 3 days with 3% RPHE, 0.12% chlorhexidine (CHX), 50,000 IU/mL nystatin (NYS) or saline (0.9% NaCl). Biofilms were analyzed regarding the number of viable microorganisms (CFU/mL), the metabolic activity (MTT assay) and the proportion of hyphae (optical microscopy). The MIC and MFC of RPHE were respectively 0.29 mg/mL (0.03%) and 1.17 mg/mL (0.12%). There was no difference in the microorganisms? viability (CFU/mL) among groups treated with RPHE (4.92×103), CHX (3.33×102) or NYS (6.8×104), being all of them different from NaCl (3.93×107) (p0.05). All experimental groups had a mean proportion of hyphae <10%, lower than NaCl (70%). RPHE has antifungal activity against C. albicans biofilms, suggesting its use for the biofilm control on denture surfaces

Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil

To evaluate the prevalence of oral cancer in Brazil according to the clinical stage, anatomical location, alcoholism and smoking. Data referring to 31,217 cases of oral cancer, from 2000 to 2010, were obtained from the Integrator Module of the Hospital Registry of Cancer. Inconsistent data (?non-classified? cases) was eliminated and 21,160 cases were analyzed. The frequency distribution according to clinical stage, anatomical location, alcoholism and smoking was analyzed descriptively and through a binary logistic regression model (?<0.05). The clinical stage (dependent variable) was dichotomized in early stage (I and II) or advanced stage (III and IV). The year of diagnosis, anatomical location and deleterious habits (alcoholism and smoking) were considered independent variables. The most frequent characteristics were: oropharynx location (n=3856, 18.41%), clinical stage IV (n=11924, 56.09%) and combined use of alcohol and tobacco (n=19226; 61.59%). The year 2009 (p<0.01, PR = 1.162, CI-95%=1.053-1.283) and location at the base of tongue (p<0.01, PR = 2.485, CI-95% = 2.182-2.807) presented a higher prevalence ratio for advanced stage oral cancer. The combined use of alcohol and tobacco showed a higher prevalence rate for the advanced clinical stage of cancer (p<0.01, PR =1.449, CI-95%=1.382-1.520) if compared to individuals without habits, or just alcoholics. Higher prevalence of advanced stage of oral cancer is related to the localization at the base of the tongue and to the concomitant use of alcohol and tobacco. Therefore, it can be suggested that all these characteristics lead to a worse prognosis of oral cancer

The Xylitol Applicability and its Effects in Health Area Worldwide: A Bibliometric Analysis Based on Randomized Controlled Trials

Objective:&nbsp;To describe and evaluate the xylitol products’ applicability and its effects in the health area worldwide utilizing a bibliometric analysis from randomized controlled trials (RCT) with humans.&nbsp;Material and Methods:&nbsp;Electronic searches were carried out in Medline/PubMed, Scopus, Cochrane Library, Web of Science, and VHL databases. The main data extracted were: year, area of applicability, type of treatment, country, journal, xylitol posology and concentration, presentation form, outcomes, and effects.&nbsp;Results:&nbsp;From 1476 studies, 257 were included. These studies were published between 1973-2021. The majority was carried out in dentistry (73.9%) and under preventive treatment (67.4%). These studies were developed in the USA (15.4%) and published in Caries Research (6.6%). The posology and concentration ranged between 0.004-67 g/day and 0.002-100%, respectively. The xylitol is usually used in the chewing gum form (44.0%), and for antimicrobial activity evaluation (38.5%). A positive effect was observed in 204 studies (79.3%) and was associated with xylitol concentration ≥ 15% (p=0.007). Side effects were reported in 8.2% and were associated with posology ≥ 5 g/day (p=0.03).&nbsp;Conclusion:&nbsp;Most studies with xylitol were conducted to prevent diseases in the dentistry field. The chewing gum form and antimicrobial activity evaluation were more frequent. Most xylitol products have a positive effect, and few studies report side effects

Manejo da dor e dificuldades relatadas pela equipe de enfermagem na administração de opióides

O estudo teve como objetivos identificar a intensidade mínima de dor auto-relatada necessária para que técnicos e auxiliares de enfermagem iniciem a terapêutica analgésica farmacológica, se esses profissionais avaliam a dor no período pós-procedimento, e quais as dificuldades que encontram para a administração de analgésicos. Estudo quantitativo, exploratório, realizado em um Hospital Universitário no norte do Paraná. Participaram 188 técnicos/auxiliares de enfermagem. Como resultados, 58,4% dos profissionais administram analgésicos diante do relato de dor leve, 39% de dor moderada e 2,6% de dor intensa. 85% dos profissionais avaliam a dor após a administração do analgésico. As dificuldades na administração referem-se à ausência de prescrição de analgésicos (65%) e a falta destes na farmácia (19%). O medo da dependência de opióides foi relatado por 76% participantes. Sugere-se que os pacientes tenham recebido uma analgesia insuficiente, o que propicia aumento do sofrimento no doente com dor. Descritores: Dor; Analgesia; Morfina; Cuidados de Enfermagem; Analgésicos Opióides

Clinical Findings Arising from the Use of Silver Diamine Fluoride to Prevent or Treat Caries Lesions and Dentinal Hypersensitivity: A Data Mining Analysis

Objective:&nbsp;To summarize data of clinical trials that used silver diamine fluoride (SDF) to prevent and treat caries lesions and dentinal hypersensitivity.&nbsp;Material and Methods:&nbsp;Six electronic databases were searched in May 2022. The concentration of SDF, type of usage (alone/combined), dentition, anterior/posterior teeth, tooth region, dental tissue, number of the treated surfaces, the intervention environment, participants\u27 age, frequency and duration of SDF application, purpose, and outcome were the extracted variables. The type of study, year of publication, authors, journals, and country were also investigated.&nbsp;Results:&nbsp;From 8860 articles, 53 were selected. Most were randomized (n=38), that applied 38% SDF (n=43), alone (n=44), on multiple surfaces (n=44), only in dentin (n=36), of the crown (n=46) of anterior and posterior (n=36) primary teeth (n=39). The studies were preferably carried out outside the clinic (n=31), only in children (n=33), with reapplication of SDF (n=30), but did not inform the duration of application (n=19). SDF was most used to treat (n=46) only caries lesions (n=50). They were published between 2001 and 2022, mainly in the Journal of Dentistry (n=10). China (n=19) and Lo E.C.M (n=19) were the countries and authors that published the most, respectively.&nbsp;Conclusion:&nbsp;The silver diamine fluoride 38% alone was most used to treat caries lesions in the dentin of the crown of all primary teeth, preferably applied on multiple surfaces, requiring reapplication, and outside the clinic

A Data Mining Analysis on Niobium in Dentistry: Promising Alloys for Dental Materials

Objective:&nbsp;To investigate the trends of research on niobium (Nb) in dentistry to determine its use in dental materials.&nbsp;Material and Methods: Electronic searches were carried out in six databases. Studies that evaluated niobium alloys in dentistry in vitro, in situ, and in vivo (humans and animals) were included. Data on publication year, authors, country, journal, study design, application area, niobium alloy, study approach, assay type and results (positive, negative and null compared to controls) were grouped and analyzed in VantagePoint™ and Excel. Descriptive analyses of frequency, cross-tables and co-occurrence matrices were performed.&nbsp;Results:&nbsp;After screening, 315 studies published between 1977 and 2021 were included, with an increase in publications between 2011 and 2021 (n=209; 66.3%). “Doi, H” was the top author (n=9; 2.8%), and Brazil was the most productive country (n=70; 22.2%). “Dental Materials” was the major contributing journal (n=24; 7.6%), and most studies were carried out in vitro (n=266; 84.4%), under implant surfaces (n=162; 51.4%), followed by dental prostheses (n=77; 24.4%) and restorative materials (n=27; 8.6%). The most common niobium was a ternary alloy (n=147; 46.7%), which was mainly tested in vitro via structural characterization or material improvement (n=131; 41.6%). Mechanical assays (n=114; 36.2%) were the most prevalent. Positive effects of niobium were found in 264 articles (83.8%), and negative effects were found in 13 articles (4.1%).&nbsp;Conclusion: The number of studies on niobium has increased over time, resulting in improvements in the mechanical properties of materials used in dental practice

Clinical Findings Arising from the Use of Silver Diamine Fluoride to Prevent or Treat Caries Lesions and Dentinal Hypersensitivity: A Data Mining Analysis

Objective: To summarize data of clinical trials that used silver diamine fluoride (SDF) to prevent and treat caries lesions and dentinal hypersensitivity. Material and Methods: Six electronic databases were searched in May 2022. The concentration of SDF, type of usage (alone/combined), dentition, anterior/posterior teeth, tooth region, dental tissue, number of the treated surfaces, the intervention environment, participants' age, frequency and duration of SDF application, purpose, and outcome were the extracted variables. The type of study, year of publication, authors, journals, and country were also investigated. Results: From 8860 articles, 53 were selected. Most were randomized (n=38), that applied 38% SDF (n=43), alone (n=44), on multiple surfaces (n=44), only in dentin (n=36), of the crown (n=46) of anterior and posterior (n=36) primary teeth (n=39). The studies were preferably carried out outside the clinic (n=31), only in children (n=33), with reapplication of SDF (n=30), but did not inform the duration of application (n=19). SDF was most used to treat (n=46) only caries lesions (n=50). They were published between 2001 and 2022, mainly in the Journal of Dentistry (n=10). China (n=19) and Lo E.C.M (n=19) were the countries and authors that published the most, respectively. Conclusion: The silver diamine fluoride 38% alone was most used to treat caries lesions in the dentin of the crown of all primary teeth, preferably applied on multiple surfaces, requiring reapplication, and outside the clinic

Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em essência, a contribuição do VII Encontro Brasileiro de Educomunicação ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3&nbsp;e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma média de entre 7 e 10 páginas, cada um. Com este rico e abundante material, chegamos ao sétimo e-book publicado pela ABPEducom, em seus seis primeiros anos de existência. A especificidade desta obra é a de trazer as “Áreas de Intervenção” do campo da Educomunicação, colocando-as a serviço de uma meta essencial ao agir educomunicativo: o diálogo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue