203 research outputs found
Psychological aspects of students with learning disabilities in e-environments: a mini review and future research directions
What are the main learning difficulties or advantages encountered by students with learning disabilities within e-environments? As a result of the Covid-19 emergency, e-learning is being increasingly used to support studentsâ learning processes. A number of countries closed their schools altogether, so face-to-face lessons were and have been replaced by distance lessons. A search of current literature via Scopus, Eric and Google Scholar electronic databases was conducted according to Prisma Guidelines. Other sources of literature were also considered, starting from the references in the full text of the articles consulted. We used the following search keywords: âlearning disabilitiesâ combined with the âAND/ORâ Boolean operator and âe-learning platformsâ, âwell-beingâ, âpsychological factorsâ, âemotional distressâ, âself-regulationâ. One body of literature highlights the lack of inclusive accessibility standards and a lack of attention to specific tools for addressing neuropsychological syndromes, which causes students to develop high levels of stress/anxiety and emotional distress, in addition to low levels of well-being, self-esteem and self-efficacy. Another area of literature looks at how students can develop high levels of self-regulation and emotional awareness, as well as high levels of inclusion. Results are discussed in terms of the promotion of e-learning that focuses on the psychological well-being of students and teachers use of technological tool
Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities
A novel and efficient procedure to prepare highly oxidised aryltetralin lignans, such as isopodophyllotoxone and (-)-aristologone
derivatives, by oxidation of podophyllotoxin and galbulin with methylrhenium trioxide (MTO) and novel MTO heterogeneous
catalysts is reported. It is noteworthy that in the case of isopodophyllotoxone derivatives the functionalisation of the
C-4 position of the C-ring and the ring-opening of the D-lactone moiety increased the activity against topoisomerase II while causing
the undesired inhibition of tubulin polymerisation to disappear. The novel (-)-aristologone derivatives showed apoptogenic
activity against resistant human lymphoma cell lines.L'articolo Ăš disponibile sul sito dell'editore: http://www.sciencedirect.co
Glutamine prevents myostatin hyperexpression and protein hypercatabolism induced in C2C12 myotubes by Tumor Necrosis Factor-alpha
Catestatin Improves Post-Ischemic Left Ventricular Function and Decreases Ischemia/Reperfusion Injury in Heart
The Chromogranin A (CgA)-derived anti-hypertensive peptide catestatin (CST) antagonizes catecholamine secretion, and is a negative myocardial inotrope acting via a nitric oxide-dependent mechanism. It is not known whether CST contributes to ischemia/reperfusion injury or is a component of a cardioprotective response to limit injury. Here, we tested whether CST by virtue of its negative inotropic activity improves post-ischemic cardiac function and cardiomyocyte survival. Three groups of isolated perfused hearts from adult Wistar rats underwent 30-min ischemia and 120-min reperfusion (I/R, Group 1), or were post-conditioned by brief ischemic episodes (PostC, 5-cycles of 10-s I/R at the beginning of 120-min reperfusion, Group 2), or with exogenous CST (75 nM for 20 min, CST-Post, Group-3) at the onset of reperfusion. Perfusion pressure and left ventricular pressure (LVP) were monitored. Infarct size was evaluated with nitroblue-tetrazolium staining. The CST (5 nM) effects were also tested in simulated ischemia/reperfusion experiments on cardiomyocytes isolated from young-adult rats, evaluating cell survival with propidium iodide labeling. Infarct size was 61 ± 6% of risk area in hearts subjected to I/R only. PostC reduced infarct size to 34 ± 5%. Infarct size in CST-Post was 36 ± 3% of risk area (P < 0.05 respect to I/R). CST-Post reduced post-ischemic rise of diastolic LVP, an index of contracture, and significantly improved post-ischemic recovery of developed LVP. In isolated cardiomyocytes, CST increased the cell viability rate by about 65% after simulated ischemia/reperfusion. These results suggest a novel cardioprotective role for CST, which appears mainly due to a direct reduction of post-ischemic myocardial damages and dysfunction, rather than to an involvement of adrenergic terminals and/or endothelium
The sxt Gene and Paralytic Shellfish Poisoning Toxins as Markers for the Monitoring of Toxic Alexandrium Species Blooms
Paralytic shellfish poisoning (PSP) is a serious human illness
caused by the ingestion of seafood contaminated with saxitoxin and its
derivatives (STXs). These toxins are produced by some species of marine
dinoflagellates within the genus Alexandrium. In the Mediterranean Sea, toxic
Alexandrium spp. blooms, especially of A. minutum, are frequent and intense
with negative impact to coastal ecosystem, aquaculture practices and other
economic activities. We conducted a large scale study on the sxt gene and
toxin distribution and content in toxic dinoflagellate A. minutum of the
Mediterranean Sea using both quantitative PCR (qPCR) and HILIC-HRMS
techniques. We developed a new qPCR assay for the estimation of the sxtA1
gene copy number in seawater samples during a bloom event in Syracuse Bay
(Mediterranean Sea) with an analytical sensitivity of 2.0 à 10° sxtA1 gene
copy number per reaction. The linear correlation between sxtA1 gene copy
number and microalgal abundance and between the sxtA1 gene and STX
content allowed us to rapidly determine the STX-producing cell concentrations of two Alexandrium species in environmental
samples. In these samples, the amount of sxtA1 gene was in the range of 1.38 Ă 105 â 2.55 Ă 108 copies/L and the STX
concentrations ranged from 41â201 nmol/L. This study described a potential PSP scenario in the Mediterranean Sea.VersiĂłn del editor5,228
Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury
Avaliação da qualidade microbiológica de fórmulas infantis desidratadas após reconstituição e durante o armazenamento no lactårio de um Hospital Universitårio
Introduction: Infant formulas (IF) fail to reproduce the immunological and digestibility properties of breast milk; however, they can meet the estimated nutritional needs when breastfeeding is prevented. Being rich in nutrients, artificial milk is an environment conducive to the growth of microorganisms. Objective: To perform microbiological analysis of IF intended for infants prepared in the lactary of a University Hospital of Rio de Janeiro, after reconstitution and storage. Method: 60 samples of IF reconstituted lactary were collected, immediately after preparation (time 0 h) and after 18 h storage under refrigeration (< 5°C), in two different shifts A and B. The Most Probable Number (MPN) for coliform growth at 35°C and 45°C and Plate Count of Bacillus cereus were calculated, and coagulase positive Staphylococcus (SCP) and qualitative analysis of the presence of Salmonella spp. were performed. Results: IF showed values of coliforms with growth at 35°C < 0.3 MPN /mL and B. cereus and SCP < 1 Colony Forming Unit (CFU)/mL, in addition to absence of Salmonella spp./25 mL at both times studied. Conclusions: There was no growth of the analyzed microorganisms in 100% of the samples, probably due to the adequate training of the food handlers of the studied hospital.Introdução: As fĂłrmulas infantis (FI) nĂŁo conseguem reproduzir as propriedades imunolĂłgicas e de digestibilidade do leite materno, entretanto conseguem atender Ă s necessidades nutricionais estimadas quando hĂĄ impedimento do aleitamento materno. Por ser rico em nutrientes, o leite artificial Ă© um ambiente propĂcio para o crescimento de microrganismos. Objetivo: Realizar anĂĄlise microbiolĂłgica de FI destinadas a bebĂȘs preparadas no lactĂĄrio de um Hospital UniversitĂĄrio do Rio de Janeiro, apĂłs reconstituição e armazenamento. MĂ©todo: Foram coletadas 60 amostras de FI reconstituĂdas em lactĂĄrio, logo apĂłs o preparo (tempo 0 h) e depois de 18 h de armazenamento sob refrigeração (< 5ÂșC), em dois plantĂ”es diferentes A e B. Foi realizada a tĂ©cnica do NĂșmero mais ProvĂĄvel (NMP) para o crescimento de coliformes a 35ÂșC e a 45ÂșC, contagem em placa de Bacillus cereus e Staphylococcus coagulase positiva (SCP) e anĂĄlise qualitativa de presença de Salmonella spp. Resultados: As FI apresentaram valores de coliformes com crescimento a 35ÂșC < 0,3 NMP/mL e de B. cereus e SCP < 1 Unidade Formadora de ColĂŽnia (UFC)/mL, alĂ©m de ausĂȘncia de Salmonella spp./25 mL, nos dois momentos estudados. ConclusĂ”es: NĂŁo houve crescimento dos microrganismos analisados em 100% das amostras, provavelmente devido ao treinamento adequado dos manipuladores de alimentos do lactĂĄrio do hospital estudado
Significado da biodança como fonte de liberdade e autonomia na auto-reconquista no viver humano
Positron emission tomography in the diagnostic pathway for intracystic infection in adpkd and "cystic" kidneys. a case series
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