Optical coherence tomography and cystoid macular oedema following cataract extraction

[…] Ο σκοπός της μελέτης είναι να διερευνηθεί το πάχος του αμφιβληστροειδούς στην περιοχή του κεντρικού βοθρίου, μετά από χειρουργική αφαίρεση καταρράκτη άνευ επιπλοκών, στην άμεση μετεγχειρητική περίοδο και να συσχετισθεί με μεταβολές στην οπτική οξύτητα. Ως υποκλινικό οίδημα ωχράς ορίστηκε, είτε η παρουσία κυστοειδών χώρων χωρίς την συνοδό σημαντική μεταβολή της οπτικής οξύτητας (κατά 3 γραμμές Snellen), είτε η πάχυνση του αμφιβληστροειδούς κατά 2 SD, στις μετεγχειρητικές μετρήσεις

Foveal thickness after phacoemulsification as measured by optical coherence tomography

Gerasimos Th Georgopoulos, Dimitrios Papaconstantinou, Maria Niskopoulou, Marilita Moschos, Ilias Georgalas, Chrysanthi KoutsandreaGlaucoma Department, Medical School, Athens University, Athens, GreeceBackground: Despite a significant body of research, no consistency on postoperative foveal thickness as measured by optical coherence tomography (OCT), can be recorded. The purpose of our study was to evaluate the effect of uncomplicated cataract surgery in the thickness of the retina in the foveal area during the early postoperative period.Methods: In a prospective study, 79 eyes were assessed by OCT, on day 1, and weeks 2 and 4 after uncomplicated phacoemulsification with intraocular lens implantation in the Athens University Clinic. The outcome measure was the thickness of the retina in the foveal area.Results: The thickness of the retina preoperatively is significantly smaller (150.4 ± 18.8) (p < 0.05) than the thickness of the retina on day 1 (171.8 ± 21) and week 2 (159.7 ± 19) and returned to the initial levels on week 4 (152 ± 17.1). The estimated correlation coefficients between preoperative and postoperative thickness of the retina were significant (p < 0.05). Conversely, no association was found between postoperative visual acuity and thickness of the retina, neither between the phacoemulsification energy and retinal thickness. Operation time, although inversely related with postoperative visual acuity, was not associated with the thickness of the retina.Conclusions: Following phacoemulsification, an increase in the foveal thickness was detected in the early postoperative period, quantified and followed up by OCT. The foveal thickness returned to the preoperative level, 1 month following surgery in our study. No association was shown between intraoperative parameters and increased postoperative retinal thickness.Keywords: optical coherence tomography, phacoemulsification, retinal thicknes

INTRAVITREAL RANIBIZUMAB TREATMENT OF MACULAR CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS One-Year Results of a Prospective Study

Purpose: The purpose of this study was to evaluate the efficacy of intravitreal ranibizumab in eyes with macular choroidal neovascularization secondary to angioid streaks. Methods: A prospective interventional case series was conducted on eyes with macular choroidal neovascularization, secondary to angioid streaks, treated by repeated injections of intravitreal ranibizumab (0.5 mg) and completing a follow-up time of 1 year. The outcome measures were best-corrected visual acuity, greatest lesion height as evaluated by optical coherence tomography, and lesion size as assessed by fluorescein angiography. Results: Over a 16-month period, we treated 15 consecutive eyes. The average number of injections was 7.1 +/- 6 0.5. Mean best-corrected visual acuity was improved from 20/100 to 20/50 (P = 0.006). Best-corrected visual acuity either improved or stabilized in 14 eyes (93.3%). At baseline, 3 of the 15 eyes (20%) had a best-corrected visual acuity of >= 20/50 compared with 10 eyes (66.7%) at the end of the first year. Fourteen eyes (93.3%) presented reduction in greatest lesion height and stabilization or reduction in lesion size. The mean greatest lesion height was decreased from 377.3 +/- 139.7 mu m to 270.2 +/- 88.6 mu m (P < 0.001). Conclusion: Intravitreal ranibizumab is highly effective in improving or stabilizing vision and lesion morphology in patients with macular choroidal neovascularization secondary to angioid streaks. RETINA 30:1185-1189, 201