Novel2Vec: Characterising 19th Century Fiction via Word Embeddings

24th Irish Conference on Artificial Intelligence and Cognitive Science (AICS'16), University College Dublin, Dublin, Ireland, 20-21 September 2016Recently, considerable attention has been paid to word embedding algorithms inspired by neural network models. Given a large textual corpus, these algorithms attempt to derive a set of vectors which represent the corpus vocabulary in a new embedded space. This representation can provide a useful means of measuring the underlying similarity between words. Here we investigate this property in the context of annotated texts of 19th-century fiction by the authors Jane Austen, Charles Dickens, and Arthur Conan Doyle. We demonstrate that building word embeddings on these texts can provide us with an insight into how characters group differently under different conditions, allowing us to make comparisons across different novels and authors. These results suggest that word embeddings can potentially provide a useful tool in supporting quantitative literary analysis.Irish Research CouncilScience Foundation Irelan

Discovering Structure in Social Networks of 19th Century Fiction

8th International ACM Web Science Conference 2016, Hanover, Germany, 22-25 may 2016Inspired by the increasing availability of large text corpora online, digital humanities scholars are adopting computational approaches to explore questions in the field of literature from new perspectives. In this paper, we examine detailed social networks of characters, extracted from several works of 19th century fiction by Jane Austen and Charles Dickens. This allows us to apply methodologies from social network analysis, such as community detection, to explore the structure of these networks. By evaluating the results in collaboration with literary scholars, we find that the structure of the character networks can reveal underlying structural aspects within a novel, particularly in relation to plot and characterisation.Irish Research CouncilScience Foundation Irelan

Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids

1. Endothelial dysfunction has been described with ageing but the mechanisms responsible have not been clearly elucidated and might be different from one vessel to the other. This study assesses the relative contribution of endothelial nitric oxide (NO) and cyclo-oxygenase (COX) metabolites in relaxation to acetylcholine with ageing in the aorta and the small mesenteric artery of the rat. 2. In the aorta and branch II or III of superior mesenteric artery (SMA), endothelium-dependent relaxation to acetylcholine was not different between 12–14 (adult) and 32-week-old rats whereas it was reduced at 70–100 (old) weeks of age. 3. Despite an increased endothelial NO-synthase protein expression, the NO-synthase inhibitor, N(G)-nitro-L-arginine-sensitive component of relaxation decreased with ageing. 4. In old rats, exposure to the COX inhibitor, indomethacin, but not the selective COX-2 inhibitor, NS-398, potentiated response to acetylcholine. The thromboxane A(2)/prostaglandin H(2) receptor antagonist, GR 32191B enhanced relaxation to acetylcholine in aorta but it had no effect in SMA. Furthermore, acetylcholine increased thromboxane B(2) production (enzymeimmunoassay) in aorta but not in SMA. Finally, Western blot analysis showed enhanced expression of COX-1 and 2 in the two arteries with ageing. 5. These results suggest that the decrease in acetylcholine-induced relaxation with ageing involves reduced NO-mediated dilatation and increased generation of vasoconstrictor prostanoids most likely from COX-1. They also point out vascular bed heterogeneity related to the nature of prostanoids involved between the aorta (i.e., thromboxane A(2)) and the SMA (unidentified) arteries even though increased expression of COX occurs in both vessels

Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats

1. The effects of an oral daily dose (10 mg kg(−1)) of the flavonoid quercetin for 5 weeks in spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY) were analysed. 2. Quercetin induced a significant reduction in systolic (−18%), diastolic (−23%) and mean (−21%) arterial blood pressure and heart rate (−12%) in SHR but not in WKY rats. 3. The left ventricular weight index and the kidney weight index in vehicle-treated SHR were significantly greater than in control WKY and these parameters were significantly reduced in quercetin-treated SHR in parallel with the reduction in systolic blood pressure. 4. Quercetin had no effect on the vasodilator responses to sodium nitroprusside or to the vasoconstrictor responses to noradrenaline or KCl but enhanced the endothelium-dependent relaxation to acetylcholine (E(max)=58±5% vs 78±5%, P<0.01) in isolated aortae. 5. The 24 h urinary isoprostane F(2α) excretion and the plasma malonyldialdehyde (MDA) levels in SHR rats were increased as compared to WKY rats. However, in quercetin-treated SHR rats both parameters were similar to those of vehicle-treated WKY. 6. These data demonstrate that quercetin reduces the elevated blood pressure, the cardiac and renal hypertrophy and the functional vascular changes in SHR rats without effect on WKY. These effects were associated with a reduced oxidant status due to the antioxidant properties of the drug