Comparison and combination of a hemodynamics/biomarkers-based model with simplified PESI score for prognostic stratification of acute pulmonary embolism: findings from a real world study

Background: Prognostic stratification is of utmost importance for management of acute Pulmonary Embolism (PE) in clinical practice. Many prognostic models have been proposed, but which is the best prognosticator in real life remains unclear. The aim of our study was to compare and combine the predictive values of the hemodynamics/biomarkers based prognostic model proposed by European Society of Cardiology (ESC) in 2008 and simplified PESI score (sPESI).Methods: Data records of 452 patients discharged for acute PE from Internal Medicine wards of Tuscany (Italy) were analysed. The ESC model and sPESI were retrospectively calculated and compared by using Areas under Receiver Operating Characteristics (ROC) Curves (AUCs) and finally the combination of the two models was tested in hemodinamically stable patients. All cause and PE-related in-hospital mortality and fatal or major bleedings were the analyzed endpointsResults: All cause in-hospital mortality was 25% (16.6% PE related) in high risk, 8.7% (4.7%) in intermediate risk and 3.8% (1.2%) in low risk patients according to ESC model. All cause in-hospital mortality was 10.95% (5.75% PE related) in patients with sPESI score ≥1 and 0% (0%) in sPESI score 0. Predictive performance of sPESI was not significantly different compared with 2008 ESC model both for all cause (AUC sPESI 0.711, 95% CI: 0.661-0.758 versus ESC 0.619, 95% CI: 0.567-0.670, difference between AUCs 0.0916, p=0.084) and for PE-related mortality (AUC sPESI 0.764, 95% CI: 0.717-0.808 versus ESC 0.650, 95% CI: 0.598-0.700, difference between AUCs 0.114, p=0.11). Fatal or major bleedings occurred in 4.30% of high risk, 1.60% of intermediate risk and 2.50% of low risk patients according to 2008 ESC model, whereas these occurred in 1.80% of high risk and 1.45% of low risk patients according to sPESI, respectively. Predictive performance for fatal or major bleeding between two models was not significantly different (AUC sPESI 0.658, 95% CI: 0.606-0.707 versus ESC 0.512, 95% CI: 0.459-0.565, difference between AUCs 0.145, p=0.34). In hemodynamically stable patients, the combined endpoint in-hospital PE-related mortality and/or fatal or major bleeding (adverse events) occurred in 0% of patients with low risk ESC model and sPESI score 0, whilst it occurred in 5.5% of patients with low-risk ESC model but sPESI ≥1. In intermediate risk patients according to ESC model, adverse events occurred in 3.6% of patients with sPESI score 0 and 6.65% of patients with sPESI score ≥1.Conclusions: In real world, predictive performance of sPESI and the hemodynamic/biomarkers-based ESC model as prognosticator of in-hospital mortality and bleedings is similar. Combination of sPESI 0 with low risk ESC model may identify patients with very low risk of adverse events and candidate for early hospital discharge or home treatment.

La conservazione preventiva del patrimonio librario come possibile alternativa al restauro tradizionale

The present paper focuses on the close relation between library collections and their preservation environment, aiming, in particular, at highlighting the importance of promoting and sustaining the monitoring. The paper proposes some simple and ready-to-use technologies – smart monitoring – to prevent future damages

Diet of brown hare (Lepus europaeus) and food availability in High Andean mountains (Mendoza, Argentina)

Diet selection by Lepus europaeus was studied in high-altitude mountain environments with severe weather, presence of wetlands, and no agricultural activities. Diet was assessed using fecal microhistologicalanalysis, and food availability by point-quadrat transects in four habitats, two of them with wetlands. Significant differences were determined with Kruskal-Wallis ANOVA, similarities by Renkonen index, and feeding selection by χ 2 -test and Bailey ? s confidence interval. The diet included 63% of all species present. Shrubs dominated the diet.Food use was opportunistic in habitats without wetlands, where grasses and shrubs were more available. Plant cover and availability of grass-like plants were higher in wetland habitats, where shrubs and forbs were preferred and grass-like plants were avoided. Similarity between diet and food availability was higher on dry soils, dominated by grasses and shrubs, than in wetland microhabitats with higher plant cover, diversity, and percentage of grass-like plants. Dietary generalism was confirmed,especially when excluding wetland vegetation. Hard Juncaceae cushions accounted for the pronounced selectivity in habitats with wetlands. Dry soils, where shrub patches provided good food and shelter, appear as major feeding microhabitats for L. europaeus. Spatial heterogeneityprotection, at landscape and microhabitat scales, is relevant to the brown hare conservation in High Andean environments.Fil: Puig, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Rosi, Maria Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Videla, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Mendez, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; Argentin

Flexibility in the food selection by the European hare (Lepus europaeus) along the altitudinal gradient of the Southern Andean Precordillera (Argentina)

Predictions derived from the optimal foraging theory are interesting to test on wild herbivores living in mountain environments, considering the expected vegetation changes across altitudinal gradients. A lower food richness and a more generalist diet are expected as altitude increases, with higher diet diversity and a shift to browsing as food availability decreases seasonally. With broad diets and ecological adaptability, Lepus europaeus is a non-native herbivore inhabiting Andean altitudinal gradients. Diet and vegetation were analyzed using microhistological analysis and point-quadrat transects at six sampling sites, representative of altitudinal phytogeographic belts. The diet included 67 of the 109 species present in the vegetation. Lepus europaeus proved to be an intermediate feeder with a generalist and selective diet. Following the prediction for altitudinal gradients, dietary generalism increased as plant cover and diversity decreased with altitude. Differences in plant phenology and toxins justified changes in food preferences, from shrubs at the summit to grasses at lower altitudes. Seasonal changes in diet diversity were consistent with different hypotheses depending on altitude. The tundra climate at the summit determined a strong phenological decline and food scarcity during winter, when the less diverse diet was more focused on a preferred shrub, following the selective quality hypothesis. With a milder climate at lower altitudes, the winter increase in diet diversity, with inclusion of avoided shrubs, agrees with the food abundance hypothesis. Climate severity, food shortage, plant phenology, and secondary compounds are relevant for explaining the feeding strategy of European hares in these mountain environments.Fil: Puig, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Rosi, Maria Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Videla, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Mendez, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; Argentin

Influence of environmental variables and human activities on the seasonal habitat use by guanacos in Southern Andean Precordillera (Argentina)

Food availability, predation risk, climatic adversity, and human disturbance are usually considered relevant factors influencing the distribution of wild ungulates. Poaching and habitat degradation are threats to the guanaco, a native herbivore of South America characterized by ecological and behavioral adaptations to arid environments. Guanaco presence was seasonally surveyed in mountain environments of Andean Precordillera, corresponding to a protected area and its surroundings. Field surveys and satellite images processing estimated environmental variables ascribed to four predictions: resources availability, habitat complexity, weather conditions, and human activities. Generalized Linear Models estimated the probability of guanaco presence based on each prediction, whose variables with important effect were included in combined models. The main natural influence on the presence of guanaco was plant cover. Conservation activities improved this natural influence, whereas disturbing activities restricted it. The trade-off between high resources availability and low predation risk, as well as the effect of extreme weather conditions were not evident, at least in the study’s spatial scale. The model validation with new seasonal surveys confirmed a consistency over time of those environmental variables that explain the probability of guanaco presence in the Southern Andean Precordillera.Fil: Puig, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Videla, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Rosi, Maria Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Seitz, Viviana Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; Argentin

Taphonomic analysis of small mammal bone remains preyed upon by wildcats (Carnivora: Felidae) from the central Monte Desert (Mendoza, Argentina)

The present study analysed the taphonomic characteristics of small mammal bone accumulations produced bysmall felids in an area from the central Monte Desert (Mendoza, Argentina). In order to provide criteria to identifythe role that these predators had in the formation of zooarchaeological assemblages, the anatomical representation,bone breakage patterns and degrees of digestive corrosion were evaluated. The main taphonomic resultsare: low average values for the relative abundance of skeletal elements; greater representation of mandibles, maxillae,isolated incisors, humeri and femora than the remaining elements; preponderance of cranial elements withhigh proportion of isolated teeth; elevated frequencies of proximal limb bones compared with distal parts; highdegree of breakage in all skeletal elements and digestive corrosion on almost all diagnostic bones (mainly moderateand heavy). The values of the studied taphonomic variables indicate that small felids in this area made severealterations to the bones of their prey (mainly rodents), attributable to the category of extreme modifier, while preservingenough skeletal elements to allow their taphonomic characterization. Tooth marks or grooves on bonesurfaces produced by scratching and chewing were not detected. The low relative abundance of skeletal elements,the high degree of breakage and the elevated frequency of elements with digestion traces represent general taphonomicpatterns that fall within those reported for other South American small carnivores.Fil: López, José Manuel. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de Arqueología y Etnologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Rosi, Maria Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Tabeni, Maria Solana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Bender, Benjamin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Chiavazza, Horacio Daniel. Museo del Área Fundacional; Argentina. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de Arqueología y Etnologia; Argentin

Diet of a fossorial rodent (Octodontidae), above-ground food availability, and changes related to cattle grazing in the Central Monte (Argentina)

Overgrazing by livestock has caused desertification in the Monte, where ctenomyids and livestock share grasses as main food items. The diet of Ctenomys eremophilus, above-ground food availability and changes related to cattle grazing are analyzed in the arid plain of Mendoza, Argentina. The most available categories were grasses, followed by low shrubs and tall shrubs. Tuco-tucos showed dietary generalism, ate mainly above-ground plant parts, preferred grasses and avoided shrubs at both grazed and ungrazed sites. Plant cover, grass diversity and availability decreased under livestock grazing, which was reflected in the diet by a lower percentage of grasses, a shift toward low shrubs and higher number of frequently used resources. Tuco-tucos in the grazed paddock compensated for lower consumption of vegetative plant parts by increasing the use of Prosopis flexuosa pods stored inside burrows. Moreover, greater dietary variation among individuals suggests foraging restricted to the items closest to burrow holes. These feeding tactics would allow them to reduce above-ground foraging as a response to high raptor predation risk due to increased bare soil. The plant recovery detected during the rest period, favoured by moderate stocking rate and rotational grazing system, would allow coexistence of tuco-tucos and cattle.Fil: Rosi, Maria Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Puig, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Cona, Monica Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Videla, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Mendez, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Roig, Virgilio German. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; Argentin

First records of albine guanacos in the mountains of southern Andean Precordillera (Mendoza, Argentina)

La hipopigmentación, expresada como albinismo total, leucismo, xantismo o piebaldismo, ha sido registrada en gran variedad de vertebrados, generalmente con baja frecuencia. Este aporte documenta los primeros registros de guanacos con hipopigmentación en una población silvestre de la precordillera andina austral. Dichos registros se obtuvieron entre 2013 y 2017, en el marco de relevamientos científicos y recorridos de control y vigilancia efectuados en la reserva natural Villavicencio. Los hallazgos correspondieron a un adulto leucístico y una cría albina, integrados respectivamente a un grupo de solteros y a un grupo familiar. Ambos presentaban desplazamientos normales y activa interacción social, evidencias que permiten descartar dificultades en el crecimiento, obtención del alimento o integración intraespecífica. Los hallazgos descriptos, que se añaden a los previamente documentados en guanacos del norte de Argentina y Chile, no se alejan de las tasas de ocurrencia natural de hipopigmentación mencionadas en bibliografía. No obstante, el incremento de las actividades humanas en la región destaca la relevancia de monitorear sus posibles efectos sobre la población de guanacos. Si dichas actividades generasen fragmentación o contaminación ambiental, el guanaco podría sufrir estrés ambiental y endogamia, con potencial incidencia sobre la tasa de albinismo.Hypopigmentation, expressed as complete albinism, leucism, xantism, or piebaldism, has been recorded in a great variety of vertebrates, generally with low frequency. This note documents the first records of guanacos with hypopigmentation in a wild population of the Southern Andean Precordillera. These records were obtained between 2013 and 2017, in the frame of scientific investigations and tasks of control and surveillance carried out in the Villavicencio protected area. The findings corresponded to a leucistic adult and an albino young, integrated to a bachelor group and a familial group, respectively. Both showed normal movements and active social interaction, evidences that allow to discard difficulties in growing, obtaining food or intraspecific integration. The described findings, together with those previously documented for the guanaco in northern Argentina and Chile, are not far from the rates of natural occurence of hypopigmentation mentioned in bibliography. However, the increase of human activities in the region highlights the relevance of monitoring their effects on the guanaco population. If such activities generate environmental fragmentation or contamination, the guanaco could present environmental stress and endogamy, with potential incidence on the albinism rate.Fil: Puig, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Videla, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Rosi, Maria Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Seitz, Viviana Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Moreni, Jonathan. Fundación Villavicencio. Reserva Natural Villavicencio; ArgentinaFil: Pérez, Martín. Fundación Villavicencio. Reserva Natural Villavicencio; ArgentinaFil: Tobares, Roberto. Fundación Villavicencio. Reserva Natural Villavicencio; ArgentinaFil: Maldonado, Florencia. Fundación Villavicencio. Reserva Natural Villavicencio; ArgentinaFil: Martín, Sebastián. Fundación Villavicencio. Reserva Natural Villavicencio; Argentin

Genre, mouvements populaires urbains et environnement

Le désordre urbain et les défis environnementaux que nous connaissons ne sont pas perçus ni vécus pareillement aux Suds et aux Nords, par les femmes et les hommes, par les puissants et les exclus. Les mouvements populaires urbains et de lutte pour l'environnement participent de la réflexion sur les changements de paradigme de développement qui sont urgents et nécessaires. La perspective de genre donne des clés de lecture pour comprendre comment les asymétries féminin-masculin structurent la perception et l’organisation concrète de la vie sociale. La forte présence des femmes dans les organisations urbaines et de lutte pour l’environnement est généralement peu ou pas reconnue. Ce livre explore certains mouvements populaires urbains, qui participent au travail de prise de conscience et de revendications de droits et qui permettent ainsi d'envisager des alternatives sur des territoires de vie, sans plus attendre