Cardiovascular risk rate in hypertensive patients attended in primary health care units: the influence of pharmaceutical care

Cardiovascular complications are relevant due to their frequency and severity on the hypertension scenario. Studies refer Pharmaceutical Care (PC) as capable of decreasing cardiovascular risk rate (%CVR) on hypertensive patients. This study aimed to investigate, through a randomized clinical assay, the influence of PC service on the %CVR of hypertensive patients assisted in a health primary care unit from Fortaleza-Ceará. Two study groups were formed: i. Intervention Group (IG), which received orientation about taking medicines, actions aiming to prevent/solve medicine interactions and adverse effects and non-pharmacological interventions for 9 months and, ii. Control Group (CG), which received traditional assistance of the unit and was monitored during the same period. It was observed a statistically significant reduction on %CVR (10.76 to 7.86; p=0.04) and systolic blood pressure levels (SBP) (137.69 to 131.54; pAs complicações cardiovasculares apresentam relevância devido à sua freqüência e gravidade no contexto da hipertensão. Estudos referem que a prestação do Cuidado Farmacêutico (CF) é capaz de reduzir a taxa de risco cardiovascular (%RCV) em hipertensos. Esse trabalho objetivou investigar, com um ensaio clínico randomizado, a influência da prestação do CF na %RCV em hipertensos atendidos em uma unidade de atenção primária à saúde de Fortaleza-Ceará. Formarm-se dois grupos de estudo: i. Grupo Intervenção (GI), que recebeu orientações sobre tomada dos medicamentos, ações visando prevenir/resolver interações medicamentosas e reações adversas e intervenções não-farmacológicas por 9 meses e ii. Grupo Controle (GC), que recebeu assistência tradicional da unidade e foi monitorado durante o mesmo período. Observou-se redução estatisticamente significativa nas %RCV (10,76 to 7,86; p=0,04) e nos níveis de pressão arterial sistólica (PAS) (137,69 to 131,54;

In vivo antitumoural activity and composition of an oil extract of Brazilian propolis

AbstractThe present study aimed to evaluate in vivo and in vitro the antitumoural activity of a propolis extract obtained with edible vegetable oil and its fractions and also to investigate its chemical composition by LC–MS and LC–MS/MS. To evaluate the toxicological aspects related to the propolis extract treatment, hematological, biochemical, histopathological and morphological analyses of treated animals were performed. All propolis extracts showed an in vivo antitumour activity in the experimental model with a moderate toxicity effect at experimental exposure levels. The oil extract was as effective as the ethanolic extract at inhibiting tumour growth. In vitro assays showed that the whole oil extract produced better inhibition of tumour cells than its fractions. LC–MS and LC–MS/MS identified four phenolic acids and three flavonoids. The anticancer potential of the oil extract of propolis has been demonstrated and the edible vegetable oil was shown as an attractive alternative solvent to extract bioactive natural propolis components

Blood and bone parameters of quails fed different levels of sodium<br>Parâmetros sanguíneos e ósseos de codornas de corte alimentadas com diferentes níveis de sódio

We evaluated the effect of the level of sodium in the diet on blood parameters and bone development of quails for meat production. 384 Italian quails were used and distributed in a completely randomized design with six treatments and eight replicates of eight birds each. The treatments consisted of diets isonutrientes, except for the level of sodium, which were 0.07, 0.12, 0.17, 0.22, 0.27 and 0.32%. Birds were fed from 1 to 49 days old with the experimental diets and at 49 days, two birds were selected per replicate for blood collection and removal of the tibia. Were evaluated the pH and the concentration of Na, Cl and K in the blood and the length, diameter, weight, Seedor index, dry matter content and ash content, deformity and resistance to breakage of the tibia. The sodium content of the diet did not significantly affect the pH, concentrations of Na, Cl, K in the blood, length, diameter, dry matter and ash and deformity of the tibia. However, there was a quadratic effect on weight, Seedor index and resistance to breakage, with point of maximum estimated at 0.19% Na in diet, for all parameters. As the results, the best quality bone for quails was obtained with 0.19% sodium diet.<p><p> Avaliou-se o efeito do nível de sódio da ração sobre os parâmetros sanguíneos e no desenvolvimento ósseo de codornas destinadas a produção de carne. Foram utilizadas 384 codornas italianas, distribuídas em um delineamento inteiramente casualizado, com seis tratamentos e oito repetições de oito aves por unidade experimental. Os tratamentos consistiram de rações isonutrientes, exceto para o nível de sódio, que foram: 0,07; 0,12; 0,17; 0,22; 0,27 e 0,32%. As aves foram alimentadas de 1 a 49 dias de idade com as rações experimentais. Aos 49 dias, foram selecionadas duas aves por parcela para a coleta do sangue e retirada das tíbias. Foram avaliados o pH e a concentração de Na, Cl e K no sangue e o comprimento, diâmetro, peso, índice de Seedor, teor de matéria seca e cinzas, deformidade e resistência à quebra da tíbia. Os níveis de sódio da ração não influenciaram significativamente o pH, as concentrações de Na, Cl, K no sangue, comprimento, diâmetro, teor de matéria seca e cinzas e deformidade da tíbia. Entretanto, houve efeito quadrático sobre o peso, índice de Seedor e resistência à quebra, com ponto de máximo estimado em 0,19% de Na para todos os parâmetros. Conforme os resultados, a melhor qualidade óssea para codornas de corte foi obtida com 0,19% de sódio na ração

Monitoring biochemical markers during pharmacotherapeutic follow-up of type 2 diabetic patients

Loss of the modulatory role of the endothelium may be an important factor in the development of diabetic vascular diseases such as cardiac, cerebral and peripheral vascular disease, as evidenced by changes in the serum lipid profile: increased triglycerides (TG), total lipoprotein cholesterol (TC) and lowdensity lipoprotein (LDL-C), and reduced highdensity lipoprotein (HDL-C). This article describes a longitudinal intervention study conducted at the Center for Research in Diabetes and Endocrinometabolic Diseases of the Federal University of Ceará (UFC, CE, Brazil), in which 58 patients with type 2 diabetes (DM2) were monitored by recording biochemical parameters during two sessions of laboratory tests, and through monthly interview-based pharmacotherapeutic followup. The study lasted one year and was approved by the human research ethics committee of UFC. The data collected were analyzed with the aid of the program SPSS 11.0. Hypertension was present in 54.4% of patients with DM2, 64% were sedentary and overweight, 44.7% reported having relatives with cardiovascular disease and 59.5% had a family history of diabetes. The serum levels of fasting glucose, TG, TC and LDL-C and the systolic and diastolic blood pressure were reduced after the active follow-up and monitoring of patients. This result reinforces the importance of the role of the pharmacist in the control of biochemical parameters, improvement of patients’ quality of life and prevention of complications

Cardiovascular risk rate in hypertensive patients attended in primary health care units: the influence of pharmaceutical care

Cardiovascular complications are relevant due to their frequency and severity on the hypertension scenario. Studies refer Pharmaceutical Care (PC) as capable of decreasing cardiovascular risk rate (%CVR) on hypertensive patients. This study aimed to investigate, through a randomized clinical assay, the influence of PC service on the %CVR of hypertensive patients assisted in a health primary care unit from Fortaleza-Ceará. Two study groups were formed: i. Intervention Group (IG), which received orientation about taking medicines, actions aiming to prevent/solve medicine interactions and adverse effects and non-pharmacological interventions for 9 months and, ii. Control Group (CG), which received traditional assistance of the unit and was monitored during the same period. It was observed a statistically significant reduction on %CVR (10.76 to 7.86; p=0.04) and systolic blood pressure levels (SBP) (137.69 to 131.54; p<0.01) in the IG, while, in the CG, there was no significant alteration. 151 Drug Related Problem (DRP) were identified and it was realized 124 pharmaceutical interventions, with 89.2% of them resulting on solution/prevention of the problem. Our findings indicated that the inclusion of the PC service in the hypertensive health assistance was more effective at the %CVR and the SBP reduction in comparison to the traditional assistance offered