37 research outputs found
Sustainability in the logistics chain of the foreign trade at the example of ArgentinaÂŽs beef export
The food industry is more complicated and interweaves become, so that more coordination efforts in the area of the quality and amount of meat exports are necessary. The trade success depends on the as strongly interweaving between the links of the logistics chain are. In the case of the organic meat means to understand the logistic exports process in order to suggest improvements in certain rings of the logistics chain. The cattle is under thrown during the load, traffic, unloading and slaughter in stress factors, so that the animal prosperity and the meat quality are more concerned. As economic consequences one counts important losses on macroeconomic as well as microeconomic levels (plain) (i.e. the cattle breeder). This work presents an overhaul about the animal prosperity during the traffic and the slaughter as well as its connection with amount and quality of the manufactured meat what concern the decision about its exports.The conquest other markets is possible only if the industrial procedure is seen of the point of view of the consumer: what is searched for product; which are the attraction factors and why becomes (or the decision is not met) to ask organic meat from Argentina. The result depends on the production capacity others sectors within de value chain in order to supply products with lasting application of limited resources.Fil: Dichiara, Raul Oscar. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - BahĂa Blanca. Instituto de Investigaciones EconĂłmicas y Sociales del Sur. Universidad Nacional del Sur. Departamento de EconomĂa. Instituto de Investigaciones EconĂłmicas y Sociales del Sur; Argentina. Universidad Nacional del Sur; ArgentinaFil: Viceconte, Maria Angelica. Universidad Nacional del Sur; ArgentinaFil: Castro, NicolĂĄs. Universidad Nacional del Sur; Argentin
Search of extended or delayed TeV emission from GRBs with HAWC
Gamma-ray bursts (GRBs) are among the most luminous sources in the universe
and the nature of their emission up to very high energy is one of the most
important open issue connected with the study of these peculiar events. The
High Altitude Water Cherenkov (HAWC) gamma-ray observatory, installed at an
altitude of 4100 m a. s. l. in the state of Puebla (Mexico), has completed its
second year of full operations. Thanks to its instantaneous field of view of ~2
sr and its high duty cycle ( 95%), HAWC is an ideal instrument for the
study of transient phenomena such as GRBs. We performed a search for TeV
emission delayed with respect to, and of longer duration than the prompt
emission observed by satellites. We present here the results obtained by
observing at the position of a sample of GRBs detected by the Fermi and Swift
satellites from December 2014 to February 2017. The upper limits resulting from
this analysis are presented and theoretical implications are discussed.Comment: Presented at the 35th International Cosmic Ray Conference (ICRC2017),
Bexco, Busan, Korea. See arXiv:1708.02572 for all HAWC contribution
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity
This work was funded by Italian Minister of University and Research project PRIN 2017-201744BN5T. Grant funding (VKA): National Institutes of Health-National Eye Institute-R01EY029409, P30EY00179, National Institutes of Neurological Disorders and Stroke R01NS124784, Unrestricted Grant, Research to Prevent Blindness, New York, NY. This study was partially supported by the Spanish State Research Agency (10.13039/501100011033) under the auspices of MINECO (grant number PID2019-108691RB-I00) and the Andalusian Regional Government (grant CTS109).The design and synthesis of a series of 2,7-diazaspiro[4.4]nonanederivatives as potent sigma receptor (SR) ligands, associated withanalgesic activity, are the focus of this work. In this study, affinitiesat S1R and S2R were measured, and molecular modeling studies wereperformed to investigate the binding pose characteristics. The mostpromising compounds were subjected to in vitro toxicitytesting and subsequently screened for in vivo analgesicproperties. Compound 9d (AD258) exhibitednegligible in vitro cellular toxicity and a highbinding affinity to both SRs (K (i)S1R =3.5 nM, K (i)S2R = 2.6 nM), but not for otherpain-related targets, and exerted high potency in a model of capsaicin-inducedallodynia, reaching the maximum antiallodynic effect at very low doses(0.6-1.25 mg/kg). Functional activity experiments showed thatS1R antagonism is needed for the effects of 9d and thatit did not induce motor impairment. In addition, 9d exhibiteda favorable pharmacokinetic profile.Ministry of Education, Universities and Research (MIUR)
PRIN 2017-201744BN5TUnited States Department of Health & Human Services
National Institutes of Health (NIH) - USA
NIH National Eye Institute (NEI)
R01EY029409,
P30EY00179United States Department of Health & Human Services
National Institutes of Health (NIH) - USA
NIH National Institute of Neurological Disorders & Stroke (NINDS)
R01NS124784Unrestricted Grant, Research to Prevent Blindness, New York, NYSpanish Government
PID2019-108691RB-I00Andalusian Regional Government
CTS10
Modeling Gamma-ray burst Afterglow observations with an Off-axis Jet emission
Gamma-ray bursts (GRBs) are fascinating extragalactic objects. They represent
a fantastic opportunity to investigate unique properties not exhibited in other
sources. Multi-wavelength afterglow observations from some short- and
long-duration GRBs reveal an atypical long-lasting emission that evolves
differently from the canonical afterglow light curves favoring the off-axis
emission. We present an analytical synchrotron afterglow scenario, and the
hydrodynamical evolution of an off-axis top-hat jet decelerated in a stratified
surrounding environment. The analytical synchrotron afterglow model is shown
during the coasting, deceleration (off- and on-axis emission), and the
post-jet-break decay phases, and the hydrodynamical evolution is computed by
numerical simulations showing the time evolution of the Doppler factor, the
half-opening angle, the bulk Lorentz factor, and the deceleration radius. We
show that numerical simulations are in good agreement with those derived with
our analytical approach. We apply the current synchrotron model and describe
successfully the delayed non-thermal emission observed in a sample of long and
short GRBs with evidence of off-axis emission. Furthermore, we provide
constraints on the possible afterglow emission by requiring the
multi-wavelength upper limits derived for the closest Swift-detected GRBs and
promising gravitational-wave events.Comment: 36 pages, 16 figures, accepted for publication in Ap
Dual sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: design, synthesis and pharmacological evaluation
The development of Ï1 receptor antagonists hybridized with a H2S-donor is here reported. We aimed to obtain improved analgesic effects when compared to Ï1 receptor antagonists or H2S-donors alone. In an in vivo model of sensory hypersensitivity, thioamide 1a induced analgesia which was synergistically enhanced when associated with the Ï1 receptor antagonist BD-1063. The selective Ï1 receptor agonist PRE-084 completely reversed this effect. Four thioamide H2S-Ï1 receptor hybrids (5a8a) and their amide derivatives (5b8b) were synthesized. Compound 7a (AD164) robustly released H2S and showed selectivity for Ï1 receptor over Ï2 and opioid receptors. This compound induced marked analgesia that was reversed by PRE-084. The amide analogue 7b (AD163) showed only minimal analgesia. Further studies showed that 7a exhibited negligible acute toxicity, together with a favorable pharmacokinetic profile. To the best of our knowledge, compound 7a is the first dual-acting ligand with simultaneous H2S-release and Ï1 antagonistic activities.This work was financially supported by University of Catania, PIA.CE.RI. 20202022 Linea di intervento 3 Starting Grant project CARETO (grant 57722172136). This study was partially supported by the Spanish State Research Agency (10.13039/501100011033) under the auspices of MINECO (grant number PID2019-108691RB-I00), the Andalusian Regional Government (grant CTS109), the University of Catania PIA.CE.RI. 20202022 Linea di intervento 2 project DETTAGLI (grant 57722172125), and by Italian MUR, PRIN 2017, Code: 201744BN5T
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity
Designing and discovering compounds for dual-target inhibitors is challenging to synthesize new, safer, and more efficient drugs than single-target drugs, especially to treat multifactorial diseases such as cancer. The simultaneous regulation of multiple targets might represent an alternative synthetic approach to optimize patient compliance and tolerance, minimizing the risk of target-based drug resistance due to the modulation of a few targets. To this end, we conceived for the first time the design and synthesis of dual-ligands ÏR/HDACi to evaluate possible employment as innovative candidates to address this complex disease. Among all synthesized compounds screened for several tumoral cell lines, compound 6 (KiÏ1R = 38 ± 3.7; KiÏ2R = 2917 ± 769 and HDACs IC50 = 0.59 ÎŒM) is the most promising candidate as an antiproliferative agent with an IC50 of 0.9 ÎŒM on the HCT116 cell line and no significant toxicity to normal cells. Studies of molecular docking, which confirmed the affinity over Ï1R and a pan-HDACs inhibitory behavior, support a possible balanced affinity and activity between both targets
Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis
Leishmaniasis is a collection of diseases caused by more than 20 Leishmania parasite species that manifest as either visceral, cutaneous, or mucocutaneous leishmaniasis. Despite the significant mortality and morbidity associated with leishmaniasis, it remains a neglected tropical disease. Existing treatments have variable efficacy, significant toxicity, rising resistance, and limited oral bioavailability, which necessitates the development of novel and affordable therapeutics. Here, we report on the continued optimization of a series of imidazopyridines for visceral leishmaniasis and a scaffold hop to a series of substituted 2-(pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles with improved absorption, distribution, metabolism, and elimination properties
Machine-Learning Enhanced Photometric Analysis of the Extremely Bright GRB 210822A
We present analytical and numerical models of the bright long GRB 210822A at
. The intrinsic extreme brightness exhibited in the optical, which is
very similar to other bright GRBs (e.g., GRBs 080319B, 130427A, 160625A
190114C, and 221009A), makes GRB 210822A an ideal case for studying the
evolution of this particular kind of GRB. We use optical data from the RATIR
instrument starting at s, with publicly available optical data from
other ground-based observatories, as well as X-ray data from the Swift/X-ray
Telescope (XRT) and data from the Swift/Ultraviolet/Optical Telescope (UVOT).
The temporal profiles and spectral properties during the late stages align
consistently with the conventional forward shock model, complemented by a
reverse shock element that dominates optical emissions during the initial
phases ( s). Furthermore, we observe a break at s that we
interpreted as evidence of a jet break, which constrains the opening angle to
be about degrees. Finally, we apply a
machine-learning technique to model the multi-wavelength light curve of GRB
210822A using the AFTERGLOWPY library. We estimate the angle of sight
degrees, the energy ergs, the electron index , the thermal
energy fraction in electrons and in
the magnetic field , the efficiency
, and the density of the surrounding medium .Comment: Submitted to MNRAS, 11 pages, 6 figures. Fixed typo
A Genome-Wide Identification Analysis of Small Regulatory RNAs in Mycobacterium tuberculosis by RNA-Seq and Conservation Analysis
We propose a new method for smallRNAs (sRNAs) identification. First we build an effective target genome (ETG) by means of a strand-specific procedure. Then we propose a new bioinformatic pipeline based mainly on the combination of two types of information: the first provides an expression map based on RNA-seq data (Reads Map) and the second applies principles of comparative genomics leading to a Conservation Map. By superimposing these two maps, a robust method for the search of sRNAs is obtained. We apply this methodology to investigate sRNAs in Mycobacterium tuberculosis H37Rv. This bioinformatic procedure leads to a total list of 1948 candidate sRNAs. The size of the candidate list is strictly related to the aim of the study and to the technology used during the verification process. We provide performance measures of the algorithm in identifying annotated sRNAs reported in three recent published studies