Barriers to the Diagnosis of Dyslexia in Children

Dyslexia is a learning disability that impairs reading, writing, and spelling and is estimated to affect 5-20% of people (Shaywitz, 1998; Shaywitz, 2003). Although dyslexia is a life-long disability that has no cure, evidence-based treatments are available for struggling students (Shaywitz, 2003). The earlier these interventions are implemented, the better the student outcomes (Alexander & Slinger-Constant, 2004). However, despite the very high prevalence of dyslexia and time-sensitive need for treatment, many affected individuals slip through the cracks and go undiagnosed until adolescence or adulthood – most never get diagnosed at all (Shaywitz, 2003). This paper addresses potential barriers that contribute to the underdiagnoses of dyslexia in children in the United States

Synthesis Imaging of Dense Molecular Gas in the N113 HII Region of the Large Magellanic Cloud

We present aperture synthesis imaging of dense molecular gas in the Large Magellanic Cloud, taken with the prototype millimeter receivers of the Australia Telescope Compact Array (ATCA). Our observations of the N113 HII region reveal a condensation with a size of ~6" (1.5 pc) FWHM, detected strongly in the 1-0 lines of HCO+, HCN and HNC, and weakly in C_2H. Comparison of the ATCA observations with single-dish maps from the Mopra Telescope and sensitive spectra from the Swedish-ESO Submillimetre Telescope indicates that the condensation is a massive clump of ~10^4 solar masses within a larger ~10^5 solar mass molecular cloud. The clump is centered adjacent to a compact, obscured HII region which is part of a linear structure of radio continuum sources extending across the molecular cloud. We suggest that the clump represents a possible site for triggered star formation. Examining the integrated line intensities as a function of interferometer baseline length, we find evidence for decreasing HCO+/HCN and HCN/HNC ratios on longer baselines. These trends are consistent with a significant component of the HCO+ emission arising in an extended clump envelope and a lower HCN/HNC abundance ratio in dense cores.Comment: 10 pages, 6 figures, to appear in Ap

Immune Mediators of Murine Lyme Arthritis

Lyme disease is the most common vector-borne disease in both the United States and Europe; however, its pathogenesis is incompletely understood. The studies described in this thesis aid in the elucidation of mechanisms regulating murine Lyme arthritis and may suggest mechanisms by which human Lyme disease is mediated. (1) We found that the chemokine KC is responsible for neutrophil recruitment and subsequent development of Lyme arthritis and carditis. This was the first study to describe an immunological regulatory mechanism mediating disease susceptibility to murine Lyme disease, as resistant mice (B6) produce less KC than susceptible (C3H/HeJ) mice and do not develop disease. (2) We found that metabolites produced via the COX-2 pathway are important for functional resolution and that resolution is likely mediated via the PGE2/EP2 axis. (3) We found that although dietary fish oil substitution leads to a global shift in eicosanoid production (from AA/LA-derived eicosanoids to EPA/DHA-derived eicosanoids) and promotes antiinflammatory prostaglandin production, disease severity is not altered. (4) We found that eicosanoid production throughout the course of autoantibody-drive K/BxN serum-transfer arthritis differs significantly from that seen during Lyme arthritis and that patterns of eicosanoid expression reflect the severity and kinetics of each type of arthritis. These studies aid in understanding the immunological mechanisms regulating the occurrence and severity of murine Lyme arthritis

Analysis of Hydrogen Cyanide Hyperfine Spectral Components towards Star Forming Cores

Although hydrogen cyanide has become quite a common molecular tracing species for a variety of astrophysical sources, it, however, exhibits dramatic non-LTE behaviour in its hyperfine line structure. Individual hyperfine components can be strongly boosted or suppressed. If these so-called hyperfine line anomalies are present in the HCN rotational spectra towards low or high mass cores, this will affect the interpretation of various physical properties such as the line opacity and excitation temperature in the case of low mass objects and infall velocities in the case of their higher mass counterparts. This is as a consequence of the direct effects that anomalies have on the underlying line shape, be it with the line structural width or through the inferred line strength. This work involves the first observational investigation of these anomalies in two HCN rotational transitions, J=1!0 and J=3!2, towards both low mass starless cores and high mass protostellar objects. The degree of anomaly in these two rotational transitions is considered by computing the ratios of neighboring hyperfine lines in individual spectra. Results indicate some degree of anomaly is present in all cores considered in our survey, the most likely cause being line overlap effects among hyperfine components in higher rotational transitions.Comment: 8th Serbian Conference on Spectral Line Shapes in Astrophysics, Divicibare; 8 pages, 5 figure

Digital library access for illiterate users

The problems that illiteracy poses in accessing information are gaining attention from the research community. Issues currently being explored include developing an understanding of the barriers to information acquisition experienced by different groups of illiterate information seekers; creating technology, such as software interfaces, that support illiterate users effectively; and tailoring content to increase its accessibility. We have taken a formative evaluation approach to developing and evaluating a digital library interface for illiterate users. We discuss modifications to the Greenstone platform, describe user studies and outline resulting design implications

The simultaneous extraction of multiple social categories from unfamiliar faces

The research was supported by an award from the Experimental Psychology Society's Small Grant scheme.Peer reviewedPostprin

Measurements of the Young’s modulus of hydroxide catalysis bonds, and the effect on thermal noise in ground-based gravitational wave detectors

With the outstanding results from the detection and observation of gravitational waves from coalescing black holes and neutron star inspirals, it is essential that pathways to further improve the sensitivities of the LIGO and VIRGO detectors are explored. There are a number of factors that potentially limit the sensitivities of the detectors. One such factor is thermal noise, a component of which results from the mechanical loss in the bond material between the silica fibre suspensions and the test mass mirrors. To calculate its magnitude, the Young’s modulus of the bond material has to be known with reasonable accuracy. In this paper we present a new combination of ultrasonic technology and Bayesian analysis to measure the Young’s modulus of hydroxide catalysis bonds between fused silica substrates. Using this novel technique, we measure the bond Young’s modulus to be 18.5 ± 2.0 2.3     GPa . We show that by applying this value to thermal noise models of bonded test masses with suitable attachment geometries, a reduction in suspension thermal noise consistent with an overall design sensitivity improvement allows a factor of 5 increase in event rate to be achieved

Erratum to: Clinical pharmacist evaluation of medication inappropriateness in the emergency department of a teaching hospital in Malta.

The following scoring details of the ‘Medication Appropriateness Index’ (MAI) originated by Hanlon, Schmader and their colleagues were unintentionally inverted erroneously in our artic, WEST, L.M., CORDINA, M. and CUNNINGHAM, S. 2012. Clinical pharmacist evaluation of medication inappropriateness in the emergency department of a teaching hospital in Malta. Pharmacy practice [online], 10(4), pages 181-187. Available from: https://doi.org/10.4321/s1886-3655201200040000