Immune Modulation in Primary Vaccinia virus Zoonotic Human Infections

In 2010, the WHO celebrated the 30th anniversary of the smallpox eradication. Ironically, infections caused by viruses related to smallpox are being increasingly reported worldwide, including Monkeypox, Cowpox, and Vaccinia virus (VACV). Little is known about the human immunological responses elicited during acute infections caused by orthopoxviruses. We have followed VACV zoonotic outbreaks taking place in Brazil and analyzed cellular immune responses in patients acutely infected by VACV. Results indicated that these patients show a biased immune modulation when compared to noninfected controls. Amounts of B cells are low and less activated in infected patients. Although present, T CD4+ cells are also less activated when compared to noninfected individuals, and so are monocytes/macrophages. Similar results were obtained when Balb/C mice were experimentally infected with a VACV sample isolated during the zoonotic outbreaks. Taking together, the data suggest that zoonotic VACVs modulate specific immune cell compartments during an acute infection in humans

Clinical Study Immune Modulation in Primary Vaccinia virus Zoonotic Human Infections

In 2010, the WHO celebrated the 30th anniversary of the smallpox eradication. Ironically, infections caused by viruses related to smallpox are being increasingly reported worldwide, including Monkeypox, Cowpox, and Vaccinia virus (VACV). Little is known about the human immunological responses elicited during acute infections caused by orthopoxviruses. We have followed VACV zoonotic outbreaks taking place in Brazil and analyzed cellular immune responses in patients acutely infected by VACV. Results indicated that these patients show a biased immune modulation when compared to noninfected controls. Amounts of B cells are low and less activated in infected patients. Although present, T CD4 + cells are also less activated when compared to noninfected individuals, and so are monocytes/macrophages. Similar results were obtained when Balb/C mice were experimentally infected with a VACV sample isolated during the zoonotic outbreaks. Taking together, the data suggest that zoonotic VACVs modulate specific immune cell compartments during an acute infection in humans

Factors related to depressive complaints on climacteric: a cross-sectional study

Introduction: Climacterium is a period of a woman's life, between 35 and 65 years old, marked by hormonal and biopsychosocial changes that can lead to the onset of depressive symptoms. The aim was to identify the prevalence of and factors associated with depressive symptoms in climacteric women.Method: An exploratory study, of cross-sectional type research, was carried out in Cajazeiras, Paraíba, Brazil, from January 2013 to March 2014. The sample included 411 women aged 40 to 60. Data collection was done by interviews using a structured script. Mean and standard deviation of age variables and per capita income were identified. For correlation between the variables, we used odds ratios (CI 95%), the X² and Fisher's Exact Test, with a significance level of 5%.Results: The average age of women was 49.73 (± 5.799) years. Depressive complaints prevailed in 68.1%, associated with advanced age (p = 0.009; OR: 1693 [CI 1113–2577]), low education (p = 0.022; OR: 1568 [CI 1032–2382]), lower per capita income (p = 0.043; OR: 1553 [CI 1012–2384]), unpaid labor activity (p = 0.013; OR: 1641 [CI 1079–2495]), menopausal/postmenopausal (p = 0.011; OR: 1667 [CI 1092–2545]), sexual activity with complaint (p < 0.001 [OR: 2.777; [CI 1628–4737]) and the presence of at least one disease (p < 0.001; OR: 2230 [CI 1445–3440]).Conclusion: Understanding and addressing the factors related to depressive complaints during climacterium supports the importance of conducting disease prevention programmes, thus delaying the onset of morbidity and improving quality of life

Sisprenatal As An Evaluation Instrument of the Pregnant Woman Care In The Strategy Family Health

Introduction: prenatal care comprises a set of care aimed at preserving the health of pregnant women and the fetus, intervening at an early stage in risk situations. The SISPRENATAL was created to oversee the actions scheduled for PHPN and facilitate the transfer of funds. However, the high rates of maternal and neonatal morbidity and mortality are still a challenge to public health. Objective: To investigate, in national literature, the use of SISPRENATAL in assessing the health care of pregnant women in the Family Health Strategy. Method: integrative systematic, which seeks to answer << How SISPRENATAL used to assess the health care of pregnant women in the ESF under the existing publications? >> The search was conducted in the databases SciELO, LILACS and BDENF, using the descriptors: women's health, information systems, prenatal care and the key word SISPRENATAL. For the analysis of the articles sought to the units of meaning that make up the corpus of 10 selected articles. Results: highlight was the publication of a small number of studies, however, consider all the SISPRENATAL an important health information tool. Conclusion: SISPRENATAL has many weaknesses in their use, which must be overcome to ensure improvements in the quality of maternal and perinatal care