The Ursinus Weekly, October 16, 1933

Freshmen hold traditional banquet at Bungalow Inn • Women consider campus problems at mass meeting • Dickinson holds grizzlies to a 7-7 tie in opening conference game • Freshman gridders down Perkiomen Prep, 12-0 • Citizens hear address on national disarmament • Old timers and undergrads enjoy dance in gymnasium • Dickinson to observe 150th anniversary this week • Varsity hockey players defeat Beaver by 3-4 score • Soccer team subdues Girard College by a 5-2 score • Men debaters to hold initial meeting tonight • Former instructor accepts position at own alma mater • Cornelia Otis Skinner to appear at Norris Theatre • Alumnae hockey stars lose to varsity eleven • Trees theme of well- attended vesper services • Artist-students\u27 concert to open culture course • Sister classes hold traditional get-together • Modern language group may organize French Club • Club discusses Pilsudski, Gomez, Feisal, and Azana • Laboratory technician addresses women students • Well-known physician to address women students • Advisor lectures on new plays before literary club • YW party postponed • Prayer discussed by Brotherhood of St. Paul • Glee Club preparing to appear in nearby towns • Dr. Homer Smith to address meeting of English group • Y.M. symposium planned • Essig injured in collision • Advisees are entertained • Ruby photographers to receive proofs this weekhttps://digitalcommons.ursinus.edu/weekly/2001/thumbnail.jp

The Ursinus Weekly, February 5, 1934

Felix Schelling to give address • Illustrated lecture to be presented • Ursinus cagers lose to LVC • Swedemen lose to Wyoming Sem. • Guest to lecture on electrotypes • Naturalist to speak on Friday, May 11 • Ursinus treasurer cited for assistance to scouting • Leroy Wilson plays for annual sophomore hop • Dr. Victor Monod to speak in April • Men\u27s debating teams to hold practice encounter Wednesday • Grizzly matmen bow to Lafayette, 30 to 8 • Questionnaire prepared to ascertain student opinion • Y.M. and Y.W. secure John R. Hart for prayer week • Women debaters plan several encounters on two questions • Dr. Omwake re-elected by college presidents\u27 ass\u27n • Dr. Philip Goepp to present students in annual recital • Ruby questionnaire to be distributed among seniors • Brotherhood of St. Paul to conduct Sunday services • Y.W. holds novel meeting • Nurses give minstrel show • Grizzly cagers trounced by Villanova wildcats • Grizzly cubs defeat frosh cagers at Villanova, 30-28 • Phoenix Independents hold U basketeers to 28-28 tie • Dean of women represents college at conferences • Hall Chemical Society hears Dr. Russell Sturgis • Curtain Club chooses plays • Stories discussed by club • Best pageants written by misses Brooks and Meyer • Intra-mural sports for winter season scheduledhttps://digitalcommons.ursinus.edu/weekly/2011/thumbnail.jp

The Ursinus Weekly, November 20, 1933

Hilarious comedy staged by dormitory committee • Men hold traditional football season smoker • Bears win fourth straight victory over Swarthmore by 13-0 score • I.N.A. convention meets at Johns Hopkins • Frosh end 1933 grid season undefeated • Pep rally dedicated to senior gridiron warriors • Main Line defeats hockey team in spirited encounter • Cast chosen for Curtain Club offering Firebrand • Woman\u27s Club entertains freshman girls at tea • Season\u27s last soccer game ends in deadlock • Woman\u27s dormitory committee sponsors bazaar and tea • I.R.C. gives armistice program at open meeting • Glee Club to give concert • Treasurers to meet Wed. • French Club to hold initial meeting Tuesday • College is host to Carmel Quarterly Club • Beta Sigma holds dance • New plan adopted for instrumental ensembles • Women students to hear pres. of medical college • William Mitchell succumbs • Y.W.C.A. considers condition of the negro • Y.M. hears prof. Boswell • Forensic Club picks questions for debating season • Modern novel is subject for English Club discussion • Litvinoff and Roosevelt appear at Debating Club • College host to reformed church workers\u27 meeting • College is given trees • Sorority pledges • Brodbeck leading in inter-dormitory football conference • History-soc. science group to hear James T. Young • College department of Sunday School gives novel party • Dance and membership pins planned by Varsity Clubhttps://digitalcommons.ursinus.edu/weekly/2006/thumbnail.jp

The Ursinus Weekly, March 12, 1934

Dr. Schelling honored on Founders\u27 Day • Cheating problem is chosen for study • Varsity courtmen close season with 45-33 victory over Lebanon Valley • Seniors promise gay week-end activities • Lawson Robertson to speak at Varsity Club banquet • Women debaters hold dual meet with Temple • Frosh down Perkiomen but lose to Wyoming Seminary • Swarthmore co-ed varsity bows to Ursinus basketeers • Philadelphia artists give recital Thursday night • Winter meeting of Board of Directors held Founders\u27 Day • Men forensic artists meet Wagner and Gettysburg • Day students down Derr to lead inter-dorm league • Cancer specialist will be chapel speaker in April • Sorority conducts vespers • Women students hear horticulture lecture • College to be scene of Asbury summer school • Local AAUW branch is under consideration • Heiges high scorer in inter-dormitory league • Lansdale Kiwanis Club hears Ursinus professor • Vertebrate anatomists visit medical schools • Community club holds annual husband\u27s night • Bacteriologist will speak to pre-medical society • Day cagers defeat Maples • YW program presented by Royersford Tri-Hi-Y • Brotherhood of St. Paul conducts two meetings • Club will discuss essay • Modern language group hears Dr. Calvin D. Yost • Phi Alpha Psi reunionhttps://digitalcommons.ursinus.edu/weekly/2016/thumbnail.jp

The Ursinus Weekly, June 5, 1933

New science building dedicated at sixty-third annual commencement • Dr. Paul Gerhard speaks at baccalaureate service • Beethoven\u27s Mass in D is commencement oratorio • Court trials featured at class day exercises • Johnsonmen down Drexel in final game of season • Ursinus Woman\u27s Club holds business meeting • Business luncheon held by alumni athletic club • Prizes awarded at annual commencement • Board of Directors holds annual session at college • Four appointments made to the teaching staff • Four honorary degrees awarded at commencement • Alumni association elects officers for the coming year • Open scholarship awards announced by committee • Annual alumni banquet held last Saturday evening • Faculty holds picnic in Trinity Reformed Church • Dr. Yost addresses seniors • Woman\u27s Club entertains senior girls at bridge tea • Club discusses Van Dyke • Tropp to head track team • Modern language officers • President and Mrs. Omwake hosts at senior reception • Received degrees today • Girls\u27 basketball squad holds annual banquet • Students present recital • English Club luncheon • James M. Anders addresses Schwenkfeldian meeting • Hall presidents initiated • Organ recital at vespers • Criticism of 1933 Ruby made by prof. Sheeder • Tau Kappa Alpha initiates and elects new officers • Ursinus Woman\u27s Club host to senior girls • Dr. and Mrs. Gerhard guests at Superhouse reception • Phi Alpha Psi entertains seniors at Freeland Househttps://digitalcommons.ursinus.edu/weekly/2058/thumbnail.jp

Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII

Animals with hemophilia are models for gene therapy, factor replacement, and inhibitor development in humans. We have actively sought dogs with severe hemophilia A that have novel factor VIII mutations unlike the previously described factor VIII intron 22 inversion. A male Old English Sheepdog with recurrent soft-tissue hemorrhage and hemarthrosis was diagnosed with severe hemophilia A (factor VIII activity less than 1% of normal). We purified genomic DNA from this dog and ruled out the common intron 22 inversion; we then sequenced all 26 exons. Comparing the results with the normal canine factor VIII sequence revealed a C→T transition in exon 12 of the factor VIII gene that created a premature stop codon at amino acid 577 in the A2 domain of the protein. In addition, 2 previously described polymorphisms that do not cause hemophilia were present at amino acids 909 and 1184. The hemophilia mutation creates a new TaqI site that facilitates rapid genotyping of affected offspring by PCR and restriction endonuclease analyses. This mutation is analogous to the previously described human factor VIII mutation at Arg583, which likewise is a CpG dinucleotide transition causing a premature stop codon in exon 12. Thus far, despite extensive treatment with factor VIII, this dog has not developed neutralizing antibodies (‘inhibitors’) to the protein. This novel mutation in a dog gives rise to severe hemophilia A analogous to a mutation seen in humans. This model will be useful for studies of the treatment of hemophilia

Improving the Quality of Child Care in the Rural South

A collaborative of six social service agencies and a state university determined that the single most pressing need of families in a 14-county, rural area was child care. The Training Resource Center, developed through a W K. Kellogg Foundation grant, worked with day care licensing and early childhood professional groups to develop a plan to address the systemic nature of the problem of how to improve the quality of child care. Programs developed included training, mentoring, NAEYC accreditation, and a resource library. After 15 months, some programs show the possibility of sustainability

Porcine and Canine von Willebrand Factor and von Willebrand Disease: Hemostasis, Thrombosis, and Atherosclerosis Studies

Use of animal models of inherited and induced von Willebrand factor (VWF) deficiency continues to advance the knowledge of VWF-related diseases: von Willebrand disease (VWD), thrombotic thrombocytopenic purpura (TTP), and coronary artery thrombosis. First, in humans, pigs, and dogs, VWF is essential for normal hemostasis; without VWF bleeding events are severe and can be fatal. Second, the ADAMTS13 cleavage site is preserved in all three species suggesting all use this mechanism for normal VWF multimer processing and that all are susceptible to TTP when ADAMTS13 function is reduced. Third, while the role of VWF in atherogenesis is debated, arterial thrombosis complicating atherosclerosis appears to be VWF-dependent. The differences in the VWF gene and protein between humans, pigs, and dogs are relatively few but important to consider in the design of VWF-focused experiments. These homologies and differences are reviewed in detail and their implications for research projects are discussed. The current status of porcine and canine VWD are also reviewed as well as their potential role in future studies of VWF-related disorders of hemostasis and thrombosis

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program

Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's Disease Biomarker Program (PDBP) and other mechanisms, no single PD marker or set of markers are ready for clinical use. Here we discuss the current state of biomarker discovery for platforms relevant to PDBP. We discuss the role of the PDBP in PD biomarker identification and present guidelines to facilitate their development. These guidelines include: harmonizing procedures for biofluid acquisition and clinical assessments, replication of the most promising biomarkers, support and encouragement of publications that report negative findings, longitudinal follow-up of current cohorts including the PDBP, testing of wearable technologies to capture readouts between study visits and development of recently diagnosed (de novo) cohorts to foster identification of the earliest markers of disease onset