Goal-driven adaptive monitoring of dynamic service oriented systems

Promotor: Krzysztof Zieliński.Recenzent: Krzysztof Cetnarowicz, Adam Grzech.Niepublikowana praca doktorska.Tyt. z ekranu tyt.Praca doktorska. Akademia Górniczo-Hutnicza im. Stanisława Staszica (Kraków). Wydział Informatyki, Elektroniki i Telekomunikacji, 2014.Zawiera bibliogr.Dostępna również w wersji drukowanej.Tryb dostępu: Internet.Model of service oriented architecture, review of approaches to SOA standardization, selected reference architecture of SOA, SOA environments, adaptability, important adaptability concepts, adaptability properties, control loop, goal driven control loop management, adaptability challenges, research related to adaptive monitoring, anomaly detection diagnosis, comprehensive approaches to adaptive monitoring, aspect of goal orientation, prior work limitations, concept of adaptive monitoring, aspects of SOA dynamics, abstraction of adaptive monitoring, SOA system meta model, topology plane, causality plane, measurement steering meta models, measurement aspects, steering aspects, monitoring process realization, monitoring goal strategy, control loop anatomy, control loop algorithms, nominals identification, sentinels selection, adaptive drill down, dynamic adaptive monitoring framework, framework requirements, SOA system enrichment, selection of the instrumentation approach, interceptor socket concept, design of monitoring mechanisms, topology discovery, causality identification, measurement acquisition, core logic of the measurement interceptor, ranges identification reporting, framework architecture, prototype implementation, technology for prototype realization, SOA dynamics in OSGi, mapping OSGi to SOA system meta-model, implementation details, communication backbone, realization of monitored service container, realization of monitoring center, evaluation, evaluation overview, experimental environment, application scenario, system setup, functional evaluation, container enrichment discovery of SOA system topology, goal orientation addressing aspects of dynamics, drill down upon single multiple anomalies, non-functional evaluation, monitoring overhead, scalability aspect

System engineering approach to planning anticancer therapies

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors’ extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research

The supplemental data for the paper: "Methodology of generation of CFD meshes and 4D shape reconstruction of coronary arteries from patient-specific dynamic CT"

<p>The supplemental data for the paper: "Methodology of generation of CFD meshes and  4D shape reconstruction of coronary arteries from patient-specific dynamic CT"</p><p>A video file (minimum play resolution is HD to see the mesh) showing the movement of the LCA throughout the heart cycle and .STL files for 10--100% (increment of 10\%) of the heart cycle phase.</p&gt

Methodology of generation of CFD meshes and 4D shape reconstruction of coronary arteries from patient-specific dynamic CT

Abstract Due to the difficulties in retrieving both the time-dependent shapes of the vessels and the generation of numerical meshes for such cases, most of the simulations of blood flow in the cardiac arteries use static geometry. The article describes a methodology for generating a sequence of time-dependent 3D shapes based on images of different resolutions and qualities acquired from ECG-gated coronary artery CT angiography. The precision of the shape restoration method has been validated using an independent technique. The original proposed approach also generates for each of the retrieved vessel shapes a numerical mesh of the same topology (connectivity matrix), greatly simplifying the CFD blood flow simulations. This feature is of significant importance in practical CFD simulations, as it gives the possibility of using the mesh-morphing utility, minimizing the computation time and the need of interpolation between boundary meshes at subsequent time instants. The developed technique can be applied to generate numerical meshes in arteries and other organs whose shapes change over time. It is applicable to medical images produced by other than angio-CT modalities

Metabolic syndrome is associated with similar long-term prognosis in non-obese and obese patients. An analysis of 45 615 patients from the nationwide LIPIDOGRAM 2004-2015 cohort studies

Aims We aimed to evaluate the association between metabolic syndrome (MetS) and long-term all-cause mortality. Methods The LIPIDOGRAM studies were carried out in the primary care in Poland in 2004, 2006 and 2015. MetS was diagnosed based on the National Cholesterol Education Program, Adult Treatment Panel III (NCEP/ATP III) and Joint Interim Statement (JIS) criteria. The cohort was divided into four groups: non-obese patients without MetS, obese patients without MetS, non-obese patients with MetS and obese patients with MetS. Differences in all-cause mortality was analyzed using Kaplan-Meier and Cox regression analyses. Results 45,615 participants were enrolled (mean age 56.3, standard deviation: 11.8 years; 61.7% female). MetS was diagnosed in 14,202 (31%) by NCEP/ATP III criteria, and 17,216 (37.7%) by JIS criteria. Follow-up was available for 44,620 (97.8%, median duration 15.3 years) patients. MetS was associated with increased mortality risk among the obese (hazard ratio, HR: 1.88 [95% CI, 1.79-1.99] and HR: 1.93 [95% CI 1.82-2.04], according to NCEP/ATP III and JIS criteria, respectively) and non-obese individuals (HR: 2.11 [95% CI 1.85-2.40] and 1.7 [95% CI, 1.56-1.85] according to NCEP/ATP III and JIS criteria respectively). Obese patients without MetS had a higher mortality risk than non-obese patients without MetS (HR: 1.16 [95% CI 1.10-1.23] and HR: 1.22 [95%CI 1.15-1.30], respectively in subgroups with NCEP/ATP III and JIS criteria applied). Conclusions MetS is associated with increased all-cause mortality risk in non-obese and obese patients. In patients without MetS obesity remains significantly associated with mortality. The concept of metabolically healthy obesity should be revised