70 research outputs found

    Progress towards a public chemogenomic set for protein kinases and a call for contributions

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    Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small molecule inhibitors, which we call chemogenomic sets, that are designed to inhibit the catalytic function of almost half the human protein kinases. In this manuscript we share our progress towards generation of a comprehensive kinase chemogenomic set (KCGS), release kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outline a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases

    Micron size optically altered regions and nanocrystal formation in femtosecond laser processed CdSxSe1−x doped silicate glass

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    Femtosecond laser processing of a CdSxSe1−x doped borosilicate glass by a 1 kHz femtosecond laser with pulse energies up to 100 ÎŒJ gave rise to smooth altered micron-size regions within the glass. The fs-laser exposed glass formed nanocrystals when heat treated above the glass transition temperature. The fluorescence intensities in the non-resonant to resonant transition regimes indicated no differences in size or preference for formation of nanocrystals within the laser exposed regions

    Mesoscopic photonic structures in glasses by femtosecond-laser fashioned confinement of semiconductor quantum dots

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    Optically tunable mesoscale structures offer unparalleled potential for photonic device applications. Here, we report the creation of composite photonic structures consisting of CdS xSe1−x quantum dots (QDs) customized within lines, first written in a glass by femtosecond laser pulses. CdS xSe1−x-doped borosilicate glasses were pulsed with a fs-laser using a 473 kHz repetition rate to create chemically distinct microscopic regions. Upon further heat treatment, these regions served as “micro-crucibles” within which quantum dots were precipitated exclusively. These results open prospects of developing other semiconductor doped glasses for versatile photonic structures useful over broader optical wavelengths

    Mesoscopic photonic structures in glasses by femtosecond-laser fashioned confinement of semiconductor quantum dots

    No full text
    Optically tunable mesoscale structures offer unparalleled potential for photonic device applications. Here, we report the creation of composite photonic structures consisting of CdS xSe1−x quantum dots (QDs) customized within lines, first written in a glass by femtosecond laser pulses. CdS xSe1−x-doped borosilicate glasses were pulsed with a fs-laser using a 473 kHz repetition rate to create chemically distinct microscopic regions. Upon further heat treatment, these regions served as “micro-crucibles” within which quantum dots were precipitated exclusively. These results open prospects of developing other semiconductor doped glasses for versatile photonic structures useful over broader optical wavelengths

    Micron size optically altered regions and nanocrystal formation in femtosecond laser processed CdSxSe1−x doped silicate glass

    No full text
    Femtosecond laser processing of a CdSxSe1−x doped borosilicate glass by a 1 kHz femtosecond laser with pulse energies up to 100 ÎŒJ gave rise to smooth altered micron-size regions within the glass. The fs-laser exposed glass formed nanocrystals when heat treated above the glass transition temperature. The fluorescence intensities in the non-resonant to resonant transition regimes indicated no differences in size or preference for formation of nanocrystals within the laser exposed regions
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